• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046313
UUCD1 version UUC-HoS-00461
Ensembl Protein ID ENSP00000242719.3
UniProt Accession Q9Y3C5; A8KAI2; Q5T7R8; RNF11_HUMAN
Genbank Protein ID BAA84683.1; AAD34118.1; BAF85736.1; BAG35959.1; CAI13140.1; EAX06831.1; AAH20964.1; AAH47654.1
Protein Name RING finger protein 11
Genbank Nucleotide ID AB024703; AF151881; AK293047; AK313140; AL162430; CH471059; BC020964; BC047654
Gene Name RNF11; CGI-123
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000123091.4 ENST00000242719.3 ENSP00000242719.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20676133; 19262463
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.20e-08 36.1 99 139
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C iC+ df   d+ ++lpC H++h+dC+  w       +++f+CP C
   Q: 99   CVICMMDFvyGDPIRFLPCMHIYHLDCIDDW------LMRSFTCPSC 139
           ********99888******************......********** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
 Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Protein Sequence
(Fasta)
MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPVYH PTPSQTRLAT 60
QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV ICMMDFVYGD PIRFLPCMHI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046313|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAGTGCCCG AGCCGGCCTC GTTCTGGCTG CCGCCGTCTC GCTGAGGCGG AGTAGGATGA 60
GGCCCGCGGC CGTGGCTCCG GCGTCGGCGG GGGCAGCAGC AGCTGAGGCA GCAGCTGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046313|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0449--Lipoprotein
KW-0479--Metal-binding
KW-0519--Myristate
KW-0539--Nucleus
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0055037--C:recycling endosome
GO:0000151--C:ubiquitin ligase complex
GO:0003677--F:DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:26994
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001762 Ailuropoda melanoleuca 99.35 8.00e-77 278.00
IUUC-Apl-003879 Anas platyrhynchos 100.00 8.00e-65 238.00
IUUC-Aca-004887 Anolis carolinensis 98.70 2.00e-73 267.00
IUUC-Ame-011194 Astyanax mexicanus 92.86 2.00e-76 277.00
IUUC-Bta-013543 Bos taurus 100.00 4.00e-66 242.00
IUUC-Bol-016328 Brassica oleracea 44.78 2.00e-12 65.10
IUUC-Cel-018152 Caenorhabditis elegans 37.01 2.00e-22 98.60
IUUC-Cja-019172 Callithrix jacchus 100.00 2.00e-74 270.00
IUUC-Cfa-020423 Canis familiaris 100.00 4.00e-64 236.00
IUUC-Cpo-021457 Cavia porcellus 100.00 2.00e-74 270.00
IUUC-Csa-024165 Chlorocebus sabaeus 100.00 2.00e-74 270.00
IUUC-Cho-024439 Choloepus hoffmanni 91.67 1.00e-73 268.00
IUUC-Cin-025246 Ciona intestinalis 79.66 4.00e-25 105.00
IUUC-Csv-026239 Ciona savignyi 61.76 5.00e-35 140.00
IUUC-Dre-027392 Danio rerio 93.51 4.00e-76 276.00
IUUC-Dno-029468 Dasypus novemcinctus 100.00 8.00e-65 238.00
IUUC-Dor-030265 Dipodomys ordii 100.00 2.00e-74 270.00
IUUC-Dme-032121 Drosophila melanogaster 53.25 2.00e-41 161.00
IUUC-Ete-032526 Echinops telfairi 100.00 2.00e-74 270.00
IUUC-Eca-033516 Equus caballus 91.95 2.00e-64 237.00
IUUC-Eeu-035261 Erinaceus europaeus 100.00 8.00e-65 238.00
IUUC-Fca-036029 Felis catus 100.00 2.00e-74 270.00
IUUC-Fal-036620 Ficedula albicollis 99.13 9.00e-66 241.00
IUUC-Gmo-038539 Gadus morhua 92.86 5.00e-76 276.00
IUUC-Gga-040240 Gallus gallus 98.05 5.00e-73 266.00
IUUC-Gac-041863 Gasterosteus aculeatus 92.86 2.00e-75 274.00
IUUC-Ggo-045517 Gorilla gorilla 100.00 2.00e-74 270.00
IUUC-Itr-048979 Ictidomys tridecemlineatus 99.35 8.00e-74 268.00
IUUC-Lch-050201 Latimeria chalumnae 90.83 2.00e-63 233.00
IUUC-Loc-052731 Lepisosteus oculatus 90.45 1.00e-72 265.00
IUUC-Laf-053374 Loxodonta africana 100.00 2.00e-65 239.00
IUUC-Mcc-055336 Macaca mulatta 100.00 2.00e-74 270.00
IUUC-Meu-055960 Macropus eugenii 99.12 2.00e-64 236.00
IUUC-Mla-059167 Melampsora laricipopulina 45.61 1.00e-09 58.50
IUUC-Mga-059363 Meleagris gallopavo 100.00 8.00e-65 238.00
IUUC-Mmr-061456 Microcebus murinus 99.35 8.00e-77 278.00
IUUC-Mdo-062780 Monodelphis domestica 98.52 3.00e-61 226.00
IUUC-Mmu-064330 Mus musculus 99.35 3.00e-77 280.00
IUUC-Mpu-065844 Mustela putorius furo 100.00 2.00e-74 270.00
IUUC-Mlu-067557 Myotis lucifugus 100.00 2.00e-74 270.00
IUUC-Nle-069160 Nomascus leucogenys 100.00 8.00e-65 238.00
IUUC-Opr-070708 Ochotona princeps 93.51 4.00e-70 256.00
IUUC-Ont-071784 Oreochromis niloticus 92.90 1.00e-75 274.00
IUUC-Oan-073071 Ornithorhynchus anatinus 91.47 6.00e-66 242.00
IUUC-Ocu-074236 Oryctolagus cuniculus 100.00 2.00e-74 270.00
IUUC-Ola-086848 Oryzias latipes 92.21 1.00e-83 301.00
IUUC-Oga-088630 Otolemur garnettii 70.78 1.00e-58 218.00
IUUC-Oar-089615 Ovis aries 100.00 2.00e-74 270.00
IUUC-Ptr-091459 Pan troglodytes 100.00 2.00e-74 270.00
IUUC-Pan-092848 Papio anubis 100.00 2.00e-74 270.00
IUUC-Psi-092968 Pelodiscus sinensis 98.70 2.00e-73 267.00
IUUC-Pfo-096923 Poecilia formosa 93.51 1.00e-84 305.00
IUUC-Pab-098483 Pongo abelii 100.00 2.00e-74 270.00
IUUC-Pca-100978 Procavia capensis 62.99 4.00e-41 160.00
IUUC-Pva-102550 Pteropus vampyrus 100.00 2.00e-74 270.00
IUUC-Ptt-103856 Puccinia triticina 45.10 2.00e-04 37.70
IUUC-Rno-105946 Rattus norvegicus 98.05 4.00e-71 259.00
IUUC-Sha-106723 Sarcophilus harrisii 99.12 5.00e-65 238.00
IUUC-Stu-112368 Solanum tuberosum 45.59 4.00e-13 67.80
IUUC-Sar-113209 Sorex araneus 100.00 2.00e-74 270.00
IUUC-Ssc-115813 Sus scrofa 100.00 2.00e-74 270.00
IUUC-Tgu-117220 Taeniopygia guttata 100.00 2.00e-65 239.00
IUUC-Tru-118754 Takifugu rubripes 93.51 6.00e-77 279.00
IUUC-Tsy-118863 Tarsius syrichta 100.00 8.00e-65 238.00
IUUC-Tni-119702 Tetraodon nigroviridis 92.86 1.00e-76 278.00
IUUC-Tbe-127266 Tupaia belangeri 100.00 6.00e-38 148.00
IUUC-Ttr-128337 Tursiops truncatus 100.00 2.00e-74 270.00
IUUC-Vpa-130786 Vicugna pacos 100.00 8.00e-65 238.00
IUUC-Xtr-132840 Xenopus tropicalis 95.45 5.00e-76 276.00
IUUC-Xma-134249 Xiphophorus maculatus 92.86 1.00e-84 304.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved