iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023204

Ensembl Protein ID

ENSCSAP00000000643.1

UniProt Accession

A0A0D9QWA4; A0A0D9QWA4_CHLSB

Genbank Protein ID

ENSCSAP00000000643

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AQIB01016667

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000004292.1	ENSCSAT00000002325.1	ENSCSAP00000000643.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-89	300.3	606	927

Active Site

Position(s)	Description	Evidence
897	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl+k+l+v+f+gE g dl Gv+ref+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G l+g++l++ ++ +l
   Q: 606  NEDLRKELWVSFSGEIGYDLVGVKREFFYCLFEEMIQPEYGMFMYPEGASCMWFPVRPKF----EKKRYF-FFGLLCGLSLFNCNVANL 689
           689********************************************************9....567888.99**************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           p++ +++k+ll++  sledl+e+ p+l k+l+ +++ + ++      +  f ++ ++  ++++ +L+p+G++i V+++Nk++Yv+++++
   Q: 690  PFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTLLDDEGDNF-----EEVFYIHFNVHWDRNDINLIPNGSSIIVNQTNKRDYVSKYID 773
           ***********************************8754444.....44555556677899**************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G +++d+++++k+++y+ gy++++p+i +Fw+++++++ ee+k+fL F+
   Q: 774  YIFNDSVKAVYEEFRRGFYKMCDEDIIKLFHPEELKDVIVGHTDYDWKTFEKNARYEPGYNSSHPTIVMFWKAFHKLTLEEKKKFLVFL 862
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg++rl  + ++++k   f+++++ ++++  ++ TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 863  TGTDRLQTKDLKNMK-ITFCCPESWNERDPMRALTCFSVLFLPKYSTMEAVEEALQVAINNNRGFG 927
           ***************.7799999999**************************************96 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MKIHSMDQGA DHMLILSSDG KPFEYDYSMK HLRSESILQE KKIIQITCGD YHSLALSKGG 60
ELFAWGQNLH GQLGVGRKFP STTTPQIVEH LAGVPLAQIS AGEAHSMALS MSGNIYSWGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAGAATGC ATTAAATTAG GAAAAAACAT GAAGATACAT TCCATGGACC AAGGAGCAGA 60
CCACATGCTG ATTCTCTCAT CAGATGGAAA ACCATTTGAG TATGATTACA GCATGAAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	77.18	0.00e+00	1491.00
IUUC-Cja-018751	Callithrix jacchus	91.70	0.00e+00	1744.00
IUUC-Cfa-020247	Canis familiaris	77.96	0.00e+00	1492.00
IUUC-Dno-029795	Dasypus novemcinctus	71.31	0.00e+00	1050.00
IUUC-Dor-030862	Dipodomys ordii	66.88	0.00e+00	1211.00
IUUC-Ete-032585	Echinops telfairi	60.49	0.00e+00	833.00
IUUC-Eca-034358	Equus caballus	76.70	0.00e+00	1439.00
IUUC-Eeu-035282	Erinaceus europaeus	65.07	0.00e+00	721.00
IUUC-Fca-036505	Felis catus	77.63	0.00e+00	1491.00
IUUC-Ggo-045445	Gorilla gorilla	91.59	0.00e+00	1652.00
IUUC-Hsa-046342	Homo sapiens	95.15	0.00e+00	1736.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	70.60	0.00e+00	1320.00
IUUC-Laf-053921	Loxodonta africana	73.71	0.00e+00	1391.00
IUUC-Mcc-054850	Macaca mulatta	99.03	0.00e+00	1805.00
IUUC-Mmr-060783	Microcebus murinus	67.10	0.00e+00	1198.00
IUUC-Mpu-066123	Mustela putorius furo	76.00	0.00e+00	1457.00
IUUC-Mlu-067914	Myotis lucifugus	76.21	0.00e+00	1410.00
IUUC-Nle-069986	Nomascus leucogenys	95.69	0.00e+00	1783.00
IUUC-Opr-070513	Ochotona princeps	69.46	0.00e+00	949.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.90	0.00e+00	1376.00
IUUC-Oga-088858	Otolemur garnettii	66.27	0.00e+00	1163.00
IUUC-Oar-089456	Ovis aries	76.94	0.00e+00	1407.00
IUUC-Ptr-091216	Pan troglodytes	95.06	0.00e+00	1649.00
IUUC-Pan-091706	Papio anubis	98.17	0.00e+00	1783.00
IUUC-Pca-100320	Procavia capensis	66.92	0.00e+00	1271.00
IUUC-Pva-102646	Pteropus vampyrus	78.64	0.00e+00	1474.00
IUUC-Sar-113605	Sorex araneus	75.60	9.00e-150	524.00
IUUC-Tsy-119240	Tarsius syrichta	67.10	0.00e+00	1239.00
IUUC-Tbe-127787	Tupaia belangeri	71.31	0.00e+00	1340.00
IUUC-Ttr-128191	Tursiops truncatus	75.00	0.00e+00	1402.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence