iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028288

UUCD1 version

UUC-DaR-00139

Ensembl Protein ID

ENSDARP00000114987.2

UniProt Accession

B0EVP5; F1QHR7; B0EVP5_DANRE

Genbank Protein ID

ABM68034.1

Protein Name

Suppressor of cytokine signaling 2; Suppressor of cytokine-signaling 2

Genbank Nucleotide ID

BX649398

Gene Name

socs2; SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000045557.5	ENSDART00000141671.2	ENSDARP00000114987.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.90e-13	49.7	153	195

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           +++ +  +SLqhLCR+aI++++++     +++LPLP++LkdYL  ++y
   Q: 153  TPVYTATPSLQHLCRIAINKTTRR-----VQELPLPNRLKDYLTDYTY 195
           5677788*****************.....7*************99876 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MTCHSSDSTE SIENERRSQS ETQVADTEQS RIATAMRDLK NTGWYWGSLT ANEAKEILQD 60
TSEGTFLVRD SSQRDYLFTI SAMTSAGPTN LRIEYKDGKF KLDSVVLVKP KLKQFDSVVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCTTTTTA AATGAGGATT AAGTCGTTAA GGACGGGCGC TCACACATAC ACACAAAGCT 60
GAAAAAAAAA GGTTCGCTGG AATATAACTA AACTGCTGGA GTAAGTAATT ATATGTGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth

KEGG

dre:562062

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	55.96	5.00e-61	227.00
IUUC-Apl-003484	Anas platyrhynchos	64.74	1.00e-56	211.00
IUUC-Aca-004253	Anolis carolinensis	59.52	4.00e-58	217.00
IUUC-Ame-011267	Astyanax mexicanus	80.19	3.00e-90	323.00
IUUC-Bta-013183	Bos taurus	64.97	1.00e-58	219.00
IUUC-Cja-018862	Callithrix jacchus	66.03	5.00e-59	220.00
IUUC-Cfa-020226	Canis familiaris	63.87	3.00e-57	214.00
IUUC-Cpo-022414	Cavia porcellus	64.10	8.00e-58	216.00
IUUC-Csa-023758	Chlorocebus sabaeus	65.38	6.00e-59	219.00
IUUC-Cho-024471	Choloepus hoffmanni	58.71	1.00e-47	182.00
IUUC-Dno-029036	Dasypus novemcinctus	57.51	7.00e-63	233.00
IUUC-Dor-030447	Dipodomys ordii	64.29	7.00e-57	212.00
IUUC-Ete-033023	Echinops telfairi	55.15	1.00e-60	225.00
IUUC-Fca-036469	Felis catus	64.74	2.00e-58	218.00
IUUC-Fal-036642	Ficedula albicollis	64.56	3.00e-57	214.00
IUUC-Gmo-039331	Gadus morhua	75.41	6.00e-54	202.00
IUUC-Gga-040809	Gallus gallus	62.35	2.00e-57	214.00
IUUC-Gac-041398	Gasterosteus aculeatus	75.13	8.00e-86	309.00
IUUC-Ggo-045341	Gorilla gorilla	65.38	7.00e-59	219.00
IUUC-Hsa-046557	Homo sapiens	56.48	4.00e-63	234.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	64.56	3.00e-58	218.00
IUUC-Lch-050160	Latimeria chalumnae	63.13	4.00e-63	233.00
IUUC-Loc-051825	Lepisosteus oculatus	81.73	3.00e-94	337.00
IUUC-Laf-053560	Loxodonta africana	65.61	3.00e-58	218.00
IUUC-Mcc-055890	Macaca mulatta	64.74	3.00e-58	218.00
IUUC-Meu-056218	Macropus eugenii	60.20	8.00e-65	239.00
IUUC-Mga-059755	Meleagris gallopavo	63.87	1.00e-55	209.00
IUUC-Mmr-061387	Microcebus murinus	64.74	2.00e-58	218.00
IUUC-Mdo-062383	Monodelphis domestica	59.70	2.00e-65	241.00
IUUC-Mmu-063443	Mus musculus	56.72	6.00e-58	216.00
IUUC-Mpu-066459	Mustela putorius furo	64.74	2.00e-57	214.00
IUUC-Mlu-068040	Myotis lucifugus	55.96	4.00e-61	227.00
IUUC-Nle-069016	Nomascus leucogenys	62.28	3.00e-59	221.00
IUUC-Opr-071087	Ochotona princeps	58.21	8.00e-64	236.00
IUUC-Ont-072340	Oreochromis niloticus	75.62	1.00e-88	318.00
IUUC-Oan-073443	Ornithorhynchus anatinus	57.51	6.00e-63	233.00
IUUC-Ocu-074539	Oryctolagus cuniculus	64.94	4.00e-57	214.00
IUUC-Ola-087004	Oryzias latipes	77.85	1.00e-70	258.00
IUUC-Oga-088438	Otolemur garnettii	64.74	3.00e-58	218.00
IUUC-Oar-089932	Ovis aries	63.69	4.00e-58	217.00
IUUC-Ptr-091037	Pan troglodytes	65.38	7.00e-59	219.00
IUUC-Pan-092767	Papio anubis	65.38	6.00e-59	219.00
IUUC-Psi-093099	Pelodiscus sinensis	61.96	2.00e-56	211.00
IUUC-Pma-094671	Petromyzon marinus	45.57	2.00e-36	145.00
IUUC-Pfo-097073	Poecilia formosa	70.05	3.00e-81	294.00
IUUC-Pab-098319	Pongo abelii	56.48	8.00e-62	229.00
IUUC-Pca-101117	Procavia capensis	65.61	5.00e-58	217.00
IUUC-Pva-102117	Pteropus vampyrus	64.74	8.00e-58	216.00
IUUC-Rno-105913	Rattus norvegicus	64.29	7.00e-58	216.00
IUUC-Sha-106500	Sarcophilus harrisii	59.60	4.00e-64	237.00
IUUC-Ssc-115252	Sus scrofa	64.33	2.00e-58	218.00
IUUC-Tgu-117524	Taeniopygia guttata	63.58	3.00e-58	217.00
IUUC-Tsy-119335	Tarsius syrichta	64.52	6.00e-56	209.00
IUUC-Tni-120263	Tetraodon nigroviridis	72.64	5.00e-81	293.00
IUUC-Tbe-127915	Tupaia belangeri	64.10	5.00e-58	216.00
IUUC-Ttr-128372	Tursiops truncatus	64.33	2.00e-58	218.00
IUUC-Vpa-130422	Vicugna pacos	64.29	7.00e-57	212.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence