iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091037

UUCD1 version

UUC-PaT-00210

Ensembl Protein ID

ENSPTRP00000009005.4

UniProt Accession

H2Q6L9; H2Q6L9_PANTR

Genbank Protein ID

JAA08328.1; JAA12220.1; JAA22635.1; JAA37279.1

Protein Name

Suppressor of cytokine signaling 2

Genbank Nucleotide ID

AACZ03085386; GABF01009925; GABD01010465; GABE01007460

Gene Name

SOCS2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000005299.5	ENSPTRT00000009740.4	ENSPTRP00000009005.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.30e-16	58.5	153	197

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ +SLqhLCRl+I++c+g      i++LPLP +LkdYL+++++q
   Q: 153  TKPLYTSAPSLQHLCRLTINKCTGA-----IWGLPLPTRLKDYLEEYKFQ 197
           678999*******************.....8***************9886 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MTLRCLEPSG NGGEGTRSQW GTAGSAEEPS PEAARLAKAL RELGQTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTISVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCCGCGGCC TCAACTAAAA GTGGCCATTG ACCTTTTAAG CTTTCGAGCA GTGATGCAAT 60
AGAATAGTAT TTCAAAGAAA AATGCTTATC GAAATTTTGG ATCCGGTTTT CCCGTGATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0060396--P:growth hormone receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth
GO:0032355--P:response to estradiol

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	96.46	3.00e-105	373.00
IUUC-Apl-003484	Anas platyrhynchos	80.39	6.00e-73	265.00
IUUC-Aca-004253	Anolis carolinensis	71.95	5.00e-72	263.00
IUUC-Ath-007106	Arabidopsis thaliana	35.59	2.50e-02	33.10
IUUC-Ame-011267	Astyanax mexicanus	62.87	2.00e-59	221.00
IUUC-Bta-013183	Bos taurus	94.95	7.00e-99	352.00
IUUC-Bra-017915	Brassica rapa	33.90	4.90e-02	32.00
IUUC-Cja-018862	Callithrix jacchus	99.49	5.00e-104	369.00
IUUC-Cfa-020226	Canis familiaris	94.92	2.00e-96	344.00
IUUC-Cpo-022414	Cavia porcellus	96.46	3.00e-105	373.00
IUUC-Csa-023758	Chlorocebus sabaeus	98.99	3.00e-108	383.00
IUUC-Cho-024471	Choloepus hoffmanni	86.84	4.00e-72	263.00
IUUC-Dre-028288	Danio rerio	56.99	1.00e-63	235.00
IUUC-Dno-029036	Dasypus novemcinctus	96.97	8.00e-107	379.00
IUUC-Dor-030447	Dipodomys ordii	98.68	2.00e-87	314.00
IUUC-Ete-033023	Echinops telfairi	94.44	1.00e-110	391.00
IUUC-Fca-036469	Felis catus	97.47	4.00e-101	359.00
IUUC-Fal-036642	Ficedula albicollis	74.53	6.00e-71	259.00
IUUC-Gmo-039331	Gadus morhua	61.54	3.00e-35	139.00
IUUC-Gga-040809	Gallus gallus	77.36	3.00e-73	266.00
IUUC-Gac-041398	Gasterosteus aculeatus	55.61	2.00e-58	218.00
IUUC-Ggo-045341	Gorilla gorilla	100.00	4.00e-104	370.00
IUUC-Hsa-046557	Homo sapiens	99.49	1.00e-116	411.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	82.69	2.00e-93	334.00
IUUC-Lch-050160	Latimeria chalumnae	61.74	1.00e-49	189.00
IUUC-Loc-051825	Lepisosteus oculatus	56.77	1.00e-61	228.00
IUUC-Laf-053560	Loxodonta africana	95.45	2.00e-98	351.00
IUUC-Mcc-055890	Macaca mulatta	98.99	4.00e-103	366.00
IUUC-Meu-056218	Macropus eugenii	80.81	2.00e-96	344.00
IUUC-Mga-059755	Meleagris gallopavo	79.61	1.00e-71	261.00
IUUC-Mmr-061387	Microcebus murinus	97.47	1.00e-105	375.00
IUUC-Mdo-062383	Monodelphis domestica	81.82	2.00e-96	344.00
IUUC-Mmu-063443	Mus musculus	93.94	6.00e-102	362.00
IUUC-Mpu-066459	Mustela putorius furo	95.96	1.00e-99	354.00
IUUC-Mlu-068040	Myotis lucifugus	97.47	3.00e-107	380.00
IUUC-Nle-069016	Nomascus leucogenys	93.94	3.00e-100	357.00
IUUC-Opr-071087	Ochotona princeps	88.38	1.00e-102	365.00
IUUC-Ont-072340	Oreochromis niloticus	57.29	2.00e-60	224.00
IUUC-Oan-073443	Ornithorhynchus anatinus	78.79	1.00e-90	324.00
IUUC-Ocu-074539	Oryctolagus cuniculus	95.43	1.00e-99	355.00
IUUC-Ogu-078951	Oryza glumaepatula	27.03	4.60e-02	32.30
IUUC-Oin-079476	Oryza indica	27.03	4.20e-02	32.70
IUUC-Oni-082613	Oryza nivara	27.03	4.20e-02	32.70
IUUC-Oru-085265	Oryza rufipogon	27.03	4.30e-02	32.70
IUUC-Ola-087004	Oryzias latipes	60.13	3.00e-55	207.00
IUUC-Oga-088438	Otolemur garnettii	96.97	4.00e-106	376.00
IUUC-Oar-089932	Ovis aries	94.95	2.00e-98	351.00
IUUC-Pan-092767	Papio anubis	98.99	3.00e-103	366.00
IUUC-Psi-093099	Pelodiscus sinensis	77.36	4.00e-74	269.00
IUUC-Pma-094671	Petromyzon marinus	48.37	4.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	50.52	2.00e-55	208.00
IUUC-Pab-098319	Pongo abelii	99.49	2.00e-109	387.00
IUUC-Pca-101117	Procavia capensis	93.94	6.00e-100	355.00
IUUC-Pva-102117	Pteropus vampyrus	95.45	1.00e-97	348.00
IUUC-Rno-105913	Rattus norvegicus	93.43	2.00e-101	361.00
IUUC-Sha-106500	Sarcophilus harrisii	81.73	7.00e-95	339.00
IUUC-Ssc-115252	Sus scrofa	96.46	3.00e-105	374.00
IUUC-Tgu-117524	Taeniopygia guttata	76.10	2.00e-70	257.00
IUUC-Tsy-119335	Tarsius syrichta	95.36	1.00e-85	307.00
IUUC-Tni-120263	Tetraodon nigroviridis	54.26	1.00e-56	212.00
IUUC-Tca-121866	Theobroma cacao	42.86	1.10e-02	34.30
IUUC-Tbe-127915	Tupaia belangeri	94.95	4.00e-96	343.00
IUUC-Ttr-128372	Tursiops truncatus	95.96	9.00e-105	372.00
IUUC-Vpa-130422	Vicugna pacos	98.68	2.00e-87	313.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence