iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089923

Ensembl Protein ID

ENSOARP00000017047.1

UniProt Accession

W5Q2V9; W5Q2V9_SHEEP

Genbank Protein ID

ENSOARP00000017047

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01051737

Gene Name

ARHGEF4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000015878.1	ENSOART00000017288.1	ENSOARP00000017047.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.40e-10	41.2	58	107

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           ++l+d    +d eL +k+Gdv++v+  + ++ +W+ g    +  +G fP+nFv+
   Q: 58   EALWDHVTMDDQELGFKAGDVIEVM--DATNREWWWG--RVADGEGWFPANFVR 107
           79**********************9..9999******..89999********97 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

ALPDGALDTA LRGDEAGSEE DLYEDVHSSS HHYSHTGGGG EQLAINELIS DGSVVCAEAL 60
WDHVTMDDQE LGFKAGDVIE VMDATNREWW WGRVADGEGW FPANFVRLRV NQDEPADDEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCTCCCTG ATGGAGCTCT GGACACAGCC CTCCGTGGAG ATGAGGCGGG CAGTGAGGAG 60
GACCTGTATG AGGATGTGCA CAGCTCCAGC CACCACTACA GCCACACTGG AGGGGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00621--RhoGEF
PF00018--SH3_1

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0046847--P:filopodium assembly
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002073	Ailuropoda melanoleuca	62.66	0.00e+00	679.00
IUUC-Apl-004117	Anas platyrhynchos	60.85	0.00e+00	696.00
IUUC-Aca-004793	Anolis carolinensis	62.19	0.00e+00	684.00
IUUC-Ame-010682	Astyanax mexicanus	56.84	3.00e-170	592.00
IUUC-Bta-013253	Bos taurus	98.36	0.00e+00	1049.00
IUUC-Bci-013634	Botrytis cinerea	25.00	4.00e-14	73.90
IUUC-Cja-019555	Callithrix jacchus	62.30	0.00e+00	673.00
IUUC-Cfa-020578	Canis familiaris	61.76	0.00e+00	675.00
IUUC-Csa-023331	Chlorocebus sabaeus	90.53	0.00e+00	996.00
IUUC-Cho-025069	Choloepus hoffmanni	34.81	9.00e-54	206.00
IUUC-Cin-025453	Ciona intestinalis	50.11	8.00e-125	440.00
IUUC-Csv-025922	Ciona savignyi	46.82	1.00e-99	357.00
IUUC-Dre-028197	Danio rerio	74.10	0.00e+00	839.00
IUUC-Dno-029679	Dasypus novemcinctus	61.98	0.00e+00	661.00
IUUC-Dor-030739	Dipodomys ordii	89.62	0.00e+00	996.00
IUUC-Ete-032545	Echinops telfairi	38.28	5.00e-45	177.00
IUUC-Eca-034299	Equus caballus	61.76	0.00e+00	674.00
IUUC-Eeu-034720	Erinaceus europaeus	34.81	3.00e-54	207.00
IUUC-Fca-036416	Felis catus	63.39	2.00e-180	625.00
IUUC-Fal-037035	Ficedula albicollis	60.93	0.00e+00	693.00
IUUC-Gmo-039587	Gadus morhua	73.65	0.00e+00	811.00
IUUC-Gga-040841	Gallus gallus	77.66	0.00e+00	904.00
IUUC-Gac-042498	Gasterosteus aculeatus	73.33	0.00e+00	814.00
IUUC-Ggo-044700	Gorilla gorilla	35.08	8.00e-56	213.00
IUUC-Hsa-045681	Homo sapiens	63.54	0.00e+00	637.00
IUUC-Itr-048380	Ictidomys tridecemlineatus	62.41	0.00e+00	676.00
IUUC-Kpa-049278	Komagataella pastoris	26.38	3.00e-16	80.90
IUUC-Lch-049639	Latimeria chalumnae	68.78	0.00e+00	778.00
IUUC-Loc-051994	Lepisosteus oculatus	75.22	0.00e+00	867.00
IUUC-Laf-054307	Loxodonta africana	62.12	0.00e+00	692.00
IUUC-Mcc-055305	Macaca mulatta	65.14	3.00e-140	491.00
IUUC-Meu-056376	Macropus eugenii	79.28	0.00e+00	750.00
IUUC-Mga-059644	Meleagris gallopavo	59.61	0.00e+00	681.00
IUUC-Mvi-060486	Microbotryum violaceum	28.70	2.00e-21	98.20
IUUC-Mmr-061664	Microcebus murinus	61.79	0.00e+00	641.00
IUUC-Mdo-062404	Monodelphis domestica	35.08	7.00e-56	213.00
IUUC-Mmu-063143	Mus musculus	34.81	5.00e-55	210.00
IUUC-Mpu-066851	Mustela putorius furo	62.66	0.00e+00	644.00
IUUC-Mlu-066956	Myotis lucifugus	62.48	0.00e+00	655.00
IUUC-Ncr-068819	Neurospora crassa	26.46	4.00e-09	57.40
IUUC-Nle-069174	Nomascus leucogenys	43.72	2.00e-42	165.00
IUUC-Opr-070209	Ochotona princeps	62.84	0.00e+00	674.00
IUUC-Ont-072637	Oreochromis niloticus	75.10	0.00e+00	829.00
IUUC-Oan-073722	Ornithorhynchus anatinus	60.68	0.00e+00	663.00
IUUC-Ocu-074885	Oryctolagus cuniculus	61.91	0.00e+00	640.00
IUUC-Ola-087155	Oryzias latipes	34.01	9.00e-53	202.00
IUUC-Oga-088758	Otolemur garnettii	63.92	0.00e+00	666.00
IUUC-Ptr-091555	Pan troglodytes	61.58	0.00e+00	685.00
IUUC-Pan-092037	Papio anubis	62.48	0.00e+00	699.00
IUUC-Psi-093865	Pelodiscus sinensis	61.14	0.00e+00	701.00
IUUC-Pfo-096918	Poecilia formosa	34.65	7.00e-53	203.00
IUUC-Pab-097910	Pongo abelii	62.12	0.00e+00	695.00
IUUC-Pca-100891	Procavia capensis	37.41	6.00e-51	196.00
IUUC-Pva-102967	Pteropus vampyrus	65.34	2.00e-148	519.00
IUUC-Rno-105479	Rattus norvegicus	36.96	1.00e-54	209.00
IUUC-Sha-107592	Sarcophilus harrisii	60.47	0.00e+00	672.00
IUUC-Ssl-108541	Sclerotinia sclerotiorum	25.00	3.00e-14	74.70
IUUC-Sar-113369	Sorex araneus	66.23	5.00e-120	424.00
IUUC-Sre-115126	Sporisorium reilianum	27.95	2.00e-23	105.00
IUUC-Tgu-117088	Taeniopygia guttata	77.36	0.00e+00	899.00
IUUC-Tru-118716	Takifugu rubripes	36.36	1.00e-55	212.00
IUUC-Tsy-118846	Tarsius syrichta	63.32	2.00e-128	452.00
IUUC-Tni-120887	Tetraodon nigroviridis	34.39	3.00e-52	201.00
IUUC-Tme-127216	Tuber melanosporum	24.86	7.00e-22	99.40
IUUC-Tbe-127248	Tupaia belangeri	36.73	9.00e-51	196.00
IUUC-Uma-129594	Ustilago maydis	27.56	5.00e-23	103.00
IUUC-Vpa-130750	Vicugna pacos	35.53	9.00e-52	199.00
IUUC-Vvi-131436	Vitis vinifera	31.25	1.30e+00	28.10
IUUC-Xtr-132676	Xenopus tropicalis	69.57	0.00e+00	810.00
IUUC-Xma-133871	Xiphophorus maculatus	34.65	1.00e-52	202.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence