iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069129

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

ADFV01186983

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000006016.1	ENSNLET00000007727.1	ENSNLEP00000007362.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-60	198.8	741	776
UBD/Beta-Prp	1.10e-86	290.6	614	776

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ +
   Q: 741  GHTNSVNHCRFsPDdKLLASCSADGTLKLWDVTSAN 776
           8***********777*****************9876 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h++ ++  +fs+d++ +a+ ++d+t++v++++tg +l +++ he+ev ++ fs d+ +++t+s D+ +k+w+  tg+ vht+ +h+++v
   Q: 614  HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQV 702
           44444445566666666666666666666666666666666666666666666665566666666666666666666666666666666 PP
   S: 98   lslsfsp.sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvy 184
            +++f   s+   l++Gs+d  +++wdl++++c + t  gh+ +vn+ +++pd++ll+s+s+D+t++lWd+                  
   Q: 703  NCCHFTNsSRrLLLATGSSDCFLKLWDLNQKECRN-TMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDVT----------------- 773
           66666553222445556666666666666666665.666666666666666666666666666666666653................. PP
   S: 185  slsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
                                                                               s +
   Q: 774  --------------------------------------------------------------------SAN 776
           ....................................................................333 PP

Organism

Nomascus leucogenys

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

MDAKARNCLL QHREALEKDI KTSYIMDHMI SDGFLTISEE EKVRNEPTQQ QRAAMLIKMI 60
LKKDNDSYVS FYNALLHEGY KDLAALLHDG IPVVSSSSGK DSVSGITSYV RTVLCEGGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAAGAGGC AGCGAGTGGA CGTGACTGCT CTATCCCGGG CAAAAGGGAT AGAACCGGAG 60
GTGGGGAGTC TGTGCTGTAA GCGATATGTA ATCTTGAGGT GCCGCAGCGG CGTCCAGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR003143--Cyt_cd1_C
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0097190--P:apoptotic signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	91.05	0.00e+00	2312.00
IUUC-Apl-004201	Anas platyrhynchos	70.42	0.00e+00	1818.00
IUUC-Aca-004638	Anolis carolinensis	68.56	0.00e+00	1797.00
IUUC-Ani-009285	Aspergillus nidulans	25.62	7.00e-67	249.00
IUUC-Ame-011062	Astyanax mexicanus	54.75	0.00e+00	1370.00
IUUC-Bta-012865	Bos taurus	90.23	0.00e+00	2324.00
IUUC-Cel-018376	Caenorhabditis elegans	21.51	6.00e-30	127.00
IUUC-Cja-018815	Callithrix jacchus	84.35	0.00e+00	2111.00
IUUC-Cfa-020222	Canis familiaris	86.53	0.00e+00	2174.00
IUUC-Cpo-021524	Cavia porcellus	88.07	0.00e+00	2266.00
IUUC-Csa-023861	Chlorocebus sabaeus	96.88	0.00e+00	2484.00
IUUC-Cho-024484	Choloepus hoffmanni	79.34	0.00e+00	1211.00
IUUC-Dre-028006	Danio rerio	53.27	0.00e+00	1259.00
IUUC-Dno-029591	Dasypus novemcinctus	90.15	0.00e+00	2328.00
IUUC-Dor-030237	Dipodomys ordii	75.95	0.00e+00	1091.00
IUUC-Ete-032620	Echinops telfairi	85.16	0.00e+00	1090.00
IUUC-Eca-033569	Equus caballus	90.15	0.00e+00	2306.00
IUUC-Eeu-035354	Erinaceus europaeus	64.38	7.00e-179	621.00
IUUC-Fca-036337	Felis catus	91.12	0.00e+00	2345.00
IUUC-Fal-037077	Ficedula albicollis	70.78	0.00e+00	1817.00
IUUC-Gmo-039687	Gadus morhua	50.82	0.00e+00	936.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.45	1.00e-41	166.00
IUUC-Gga-040299	Gallus gallus	69.46	0.00e+00	1833.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.00	0.00e+00	1281.00
IUUC-Ggo-045563	Gorilla gorilla	98.48	0.00e+00	2517.00
IUUC-Hsa-046771	Homo sapiens	98.08	0.00e+00	2508.00
IUUC-Lch-050200	Latimeria chalumnae	64.92	0.00e+00	1631.00
IUUC-Loc-052090	Lepisosteus oculatus	59.32	0.00e+00	1505.00
IUUC-Laf-053861	Loxodonta africana	90.63	0.00e+00	2322.00
IUUC-Mcc-055543	Macaca mulatta	97.44	0.00e+00	2496.00
IUUC-Meu-056688	Macropus eugenii	79.79	0.00e+00	2028.00
IUUC-Mga-059243	Meleagris gallopavo	70.15	0.00e+00	1845.00
IUUC-Mmr-061134	Microcebus murinus	86.10	0.00e+00	2011.00
IUUC-Mdo-062913	Monodelphis domestica	78.51	0.00e+00	2038.00
IUUC-Mmu-063811	Mus musculus	87.11	0.00e+00	2270.00
IUUC-Mpu-066780	Mustela putorius furo	91.12	0.00e+00	2314.00
IUUC-Mlu-067276	Myotis lucifugus	90.00	0.00e+00	2319.00
IUUC-Opr-071007	Ochotona princeps	67.02	0.00e+00	1120.00
IUUC-Ont-071348	Oreochromis niloticus	54.69	0.00e+00	1400.00
IUUC-Oan-072717	Ornithorhynchus anatinus	81.06	0.00e+00	2108.00
IUUC-Ocu-074286	Oryctolagus cuniculus	90.79	0.00e+00	1984.00
IUUC-Ola-086895	Oryzias latipes	50.25	0.00e+00	1187.00
IUUC-Oga-088678	Otolemur garnettii	90.95	0.00e+00	2338.00
IUUC-Oar-089359	Ovis aries	89.99	0.00e+00	2323.00
IUUC-Ptr-091062	Pan troglodytes	98.16	0.00e+00	2511.00
IUUC-Pan-092528	Papio anubis	98.07	0.00e+00	1443.00
IUUC-Psi-093430	Pelodiscus sinensis	73.52	0.00e+00	1915.00
IUUC-Pma-094690	Petromyzon marinus	38.56	3.00e-151	529.00
IUUC-Pfo-097204	Poecilia formosa	54.56	0.00e+00	1375.00
IUUC-Pab-097690	Pongo abelii	98.16	0.00e+00	2511.00
IUUC-Pca-100778	Procavia capensis	70.57	0.00e+00	1177.00
IUUC-Pva-102870	Pteropus vampyrus	87.97	0.00e+00	2095.00
IUUC-Rno-104889	Rattus norvegicus	87.19	0.00e+00	2236.00
IUUC-Sha-107465	Sarcophilus harrisii	78.96	0.00e+00	2082.00
IUUC-Sar-113268	Sorex araneus	90.88	0.00e+00	672.00
IUUC-Ssc-115654	Sus scrofa	89.67	0.00e+00	2315.00
IUUC-Tgu-117302	Taeniopygia guttata	70.70	0.00e+00	1826.00
IUUC-Tru-118363	Takifugu rubripes	54.29	0.00e+00	1379.00
IUUC-Tsy-119007	Tarsius syrichta	87.82	0.00e+00	2233.00
IUUC-Tni-120910	Tetraodon nigroviridis	52.96	0.00e+00	1332.00
IUUC-Tbe-127413	Tupaia belangeri	77.01	0.00e+00	1403.00
IUUC-Ttr-129213	Tursiops truncatus	84.46	0.00e+00	2126.00
IUUC-Vpa-130146	Vicugna pacos	84.95	0.00e+00	1618.00
IUUC-Xtr-132559	Xenopus tropicalis	61.10	0.00e+00	1539.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence