iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cfa-020768

Ensembl Protein ID

ENSCAFP00000027443.3

UniProt Accession

E2RGT8; E2RGT8_CANLF

Genbank Protein ID

ENSCAFP00000027443

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03012484

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000018590.3	ENSCAFT00000029523.3	ENSCAFP00000027443.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-21	76.3	788	839

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ +++  +gW++g  e  g+ G fP+n+ve+
   Q: 788  KARYDFCARDRSELSLKEGDIIKIL-NKKGQQGWWRG--EIYGRVGWFPSNYVEE 839
           788**********************.89999******..9*************86 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWDGAQV CELAQALRDG VLLCQLLNNL LPHAINLREV 60
NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTGT GGCGCCAGTG TACCCACTGG CTGATCCAGT GTCGGGTGCT GCCGCCCAGC 60
CACCGTGTGA CCTGGGACGG GGCCCAGGTG TGCGAGCTGG CACAGGCCCT CCGGGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR003096--SM22_calponin
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	81.85	0.00e+00	1232.00
IUUC-Cja-020009	Callithrix jacchus	95.74	0.00e+00	1624.00
IUUC-Cin-025115	Ciona intestinalis	38.02	1.00e-138	487.00
IUUC-Csv-025995	Ciona savignyi	37.18	3.00e-143	502.00
IUUC-Dno-029602	Dasypus novemcinctus	96.09	0.00e+00	1630.00
IUUC-Eca-033682	Equus caballus	97.04	0.00e+00	1639.00
IUUC-Fca-035629	Felis catus	96.69	0.00e+00	1665.00
IUUC-Gmo-039693	Gadus morhua	60.05	0.00e+00	959.00
IUUC-Gac-041567	Gasterosteus aculeatus	66.04	0.00e+00	1028.00
IUUC-Hsa-045886	Homo sapiens	96.21	0.00e+00	1634.00
IUUC-Itr-048730	Ictidomys tridecemlineatus	91.37	0.00e+00	1521.00
IUUC-Loc-051761	Lepisosteus oculatus	72.05	0.00e+00	1193.00
IUUC-Laf-054537	Loxodonta africana	95.74	0.00e+00	1636.00
IUUC-Mcc-054726	Macaca mulatta	95.98	0.00e+00	1634.00
IUUC-Mmr-060980	Microcebus murinus	94.78	0.00e+00	1624.00
IUUC-Mdo-061926	Monodelphis domestica	87.83	0.00e+00	1357.00
IUUC-Mmu-063942	Mus musculus	94.44	0.00e+00	1608.00
IUUC-Mpu-066000	Mustela putorius furo	98.58	0.00e+00	1646.00
IUUC-Mlu-067818	Myotis lucifugus	93.78	0.00e+00	1565.00
IUUC-Ont-072213	Oreochromis niloticus	67.45	0.00e+00	1108.00
IUUC-Ocu-074830	Oryctolagus cuniculus	79.75	0.00e+00	1204.00
IUUC-Ola-087345	Oryzias latipes	63.84	0.00e+00	1038.00
IUUC-Oga-089104	Otolemur garnettii	96.45	0.00e+00	1643.00
IUUC-Oar-089459	Ovis aries	95.98	0.00e+00	1617.00
IUUC-Ptr-090766	Pan troglodytes	95.88	0.00e+00	1513.00
IUUC-Pan-091994	Papio anubis	95.15	0.00e+00	1611.00
IUUC-Psi-093595	Pelodiscus sinensis	78.49	0.00e+00	1276.00
IUUC-Pfo-097210	Poecilia formosa	66.63	0.00e+00	1072.00
IUUC-Pab-098630	Pongo abelii	96.26	0.00e+00	1599.00
IUUC-Pva-102406	Pteropus vampyrus	95.86	0.00e+00	1583.00
IUUC-Pte-104123	Pyrenophora teres	48.33	8.00e-11	63.20
IUUC-Pyt-104567	Pyrenophora triticirepentis	53.06	2.00e-10	62.00
IUUC-Rno-105763	Rattus norvegicus	91.24	0.00e+00	1542.00
IUUC-Sha-106683	Sarcophilus harrisii	87.59	0.00e+00	1521.00
IUUC-Sly-111123	Solanum lycopersicum	50.00	2.00e-10	59.70
IUUC-Stu-112434	Solanum tuberosum	50.00	2.00e-10	59.70
IUUC-Sar-113457	Sorex araneus	81.25	0.00e+00	930.00
IUUC-Ssc-115338	Sus scrofa	97.04	0.00e+00	1529.00
IUUC-Tru-118199	Takifugu rubripes	64.14	0.00e+00	1000.00
IUUC-Tni-120548	Tetraodon nigroviridis	64.99	0.00e+00	1031.00
IUUC-Tbe-127235	Tupaia belangeri	72.08	4.00e-141	494.00
IUUC-Ttr-128916	Tursiops truncatus	89.74	0.00e+00	949.00
IUUC-Vpa-130066	Vicugna pacos	68.90	4.00e-72	266.00
IUUC-Xtr-132410	Xenopus tropicalis	71.92	0.00e+00	1246.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence