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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032023
Ensembl Protein ID FBpp0082409
UniProt Accession P20659; A4V2V9; A4V2W0; Q27255; Q27327; Q8INF9; Q960R2; Q9VFL1; TRX_DROME
Genbank Protein ID AAA29025.1; CAA90514.1; CAA90513.1; CAA83516.1; CAA83515.1; AAF55041.2; AAN13599.1; AAN13600.1; AAN13601.1; AAX52951.1; AAK93328.1
Protein Name Histone-lysine N-methyltransferase trithorax; Lysine N-methyltransferase 2A
Genbank Nucleotide ID M31617; Z50152; Z50152; Z31725; Z31725; AE014297; AE014297; AE014297; AE014297; AE014297; AY051904
Gene Name trx; KMT2A; CG8651
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0003862 FBtr0082950 FBpp0082409
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 3.30e-19 68.9 1422 1481
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek...slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrs 53
           ++C++C+++++d++   +++eC +C +w+H +C +ls       ++lp+s ++iC+kC +
   Q: 1422 NFCPICQRCYDDNDfdlKMMECGDCGQWVHSKCEGLSdeqynLLSTLPESIEFICKKCAR 1481
           79***********9999************************99***************86 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo.
 Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo.
Protein Sequence
(Fasta)
MGRSKFPGKP SKSINRKRIS VLQLEDDAAN PAEPQQPAPE SQQPSGSGSG SSAAREKGNN 60
CDNDEDDNAP GGASISGNTA SSSAGSGNSG NGSSSGSSTG SGSSGSGSTN GGSVNGGTHH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032023|E3,PHD|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
TTTATAGTTA TCGGCGCGGT CACACTGTCC GGTCGTTTTG CTTTGCTATT TCCATTTCGC 60
TCGTCGAAAA AACGCAGAAA ATGTGGAAAA TAATTGATAA ACTGTGCTAA ATAGTGTGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032023|E3,PHD|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0949--S-adenosyl-L-methionine
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR016569--MeTrfase_trithorax
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001628--Znf_hrmn_rcpt
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS51030--NUCLEAR_REC_DBD_2
PS50868--POST_SET
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET
Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0035097--C:histone methyltransferase complex
GO:0005875--C:microtubule associated complex
GO:0044665--C:MLL1/2 complex
GO:0005634--C:nucleus
GO:0005700--C:polytene chromosome
GO:0008023--C:transcription elongation factor complex
GO:0003682--F:chromatin binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0008157--F:protein phosphatase 1 binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0001654--P:eye development
GO:0008354--P:germ cell migration
GO:0007482--P:haltere development
GO:0016573--P:histone acetylation
GO:0043966--P:histone H3 acetylation
GO:0051568--P:histone H3-K4 methylation
GO:0016571--P:histone methylation
GO:0032968--P:positive regulation of transcription elongation from RNA polymerase II promoter
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0019233--P:sensory perception of pain
GO:0006351--P:transcription, DNA-templated
KEGG dme:Dmel_CG8651
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000310 Aegilops tauschii 32.24 7.00e-14 71.60
IUUC-Aml-002367 Ailuropoda melanoleuca 47.28 4.00e-93 337.00
IUUC-Atr-002455 Amborella trichopoda 50.00 9.00e-41 161.00
IUUC-Apl-003478 Anas platyrhynchos 46.55 4.00e-89 323.00
IUUC-Aca-004718 Anolis carolinensis 49.00 6.00e-96 346.00
IUUC-Aly-006448 Arabidopsis lyrata 50.60 1.00e-41 164.00
IUUC-Ath-006690 Arabidopsis thaliana 43.51 1.00e-32 134.00
IUUC-Ame-010705 Astyanax mexicanus 47.54 6.00e-93 337.00
IUUC-Bta-013578 Bos taurus 47.28 9.00e-93 335.00
IUUC-Bol-016540 Brassica oleracea 42.86 2.00e-32 134.00
IUUC-Cja-019138 Callithrix jacchus 47.43 3.00e-94 340.00
IUUC-Cfa-020020 Canis familiaris 47.28 4.00e-93 337.00
IUUC-Cpo-021552 Cavia porcellus 47.28 3.00e-93 337.00
IUUC-Cre-022891 Chlamydomonas reinhardtii 53.91 1.00e-39 159.00
IUUC-Csa-024216 Chlorocebus sabaeus 47.56 9.00e-94 338.00
IUUC-Cho-024652 Choloepus hoffmanni 44.22 8.00e-82 300.00
IUUC-Cin-025724 Ciona intestinalis 56.28 4.00e-74 272.00
IUUC-Csv-026268 Ciona savignyi 29.73 5.00e-87 315.00
IUUC-Cme-027224 Cyanidioschyzon merolae 41.98 5.00e-13 69.30
IUUC-Dre-027440 Danio rerio 48.99 2.00e-94 341.00
IUUC-Dno-029583 Dasypus novemcinctus 47.28 2.00e-93 338.00
IUUC-Dor-030903 Dipodomys ordii 47.28 4.00e-93 337.00
IUUC-Ete-032834 Echinops telfairi 48.99 1.00e-83 305.00
IUUC-Eca-034026 Equus caballus 47.28 2.00e-92 333.00
IUUC-Eeu-034687 Erinaceus europaeus 47.28 7.00e-93 336.00
IUUC-Fca-036311 Felis catus 47.28 3.00e-93 337.00
IUUC-Fal-037256 Ficedula albicollis 46.82 6.00e-91 330.00
IUUC-Gmo-039265 Gadus morhua 47.25 1.00e-91 332.00
IUUC-Gga-040828 Gallus gallus 47.11 4.00e-90 327.00
IUUC-Gac-042202 Gasterosteus aculeatus 47.83 8.00e-93 335.00
IUUC-Gma-043554 Glycine max 46.00 1.00e-34 141.00
IUUC-Ggo-044791 Gorilla gorilla 47.56 2.00e-93 337.00
IUUC-Hsa-046988 Homo sapiens 47.56 1.00e-93 338.00
IUUC-Itr-048907 Ictidomys tridecemlineatus 47.28 4.00e-93 337.00
IUUC-Lch-049704 Latimeria chalumnae 46.82 1.00e-91 332.00
IUUC-Lpe-051661 Leersia perrieri 30.67 2.00e-14 73.90
IUUC-Loc-052181 Lepisosteus oculatus 47.97 3.00e-91 331.00
IUUC-Laf-053946 Loxodonta africana 47.11 7.00e-91 330.00
IUUC-Mcc-054782 Macaca mulatta 47.56 6.00e-94 339.00
IUUC-Meu-056485 Macropus eugenii 45.95 5.00e-89 323.00
IUUC-Mtr-058327 Medicago truncatula 46.31 6.00e-33 135.00
IUUC-Mga-059943 Meleagris gallopavo 46.82 2.00e-90 328.00
IUUC-Mmr-061178 Microcebus murinus 47.11 7.00e-91 330.00
IUUC-Mdo-062648 Monodelphis domestica 47.85 2.00e-94 341.00
IUUC-Mmu-063579 Mus musculus 46.99 6.00e-93 336.00
IUUC-Mpu-066710 Mustela putorius furo 47.28 5.00e-93 336.00
IUUC-Mlu-067559 Myotis lucifugus 47.28 9.00e-93 335.00
IUUC-Nle-070085 Nomascus leucogenys 47.56 2.00e-93 337.00
IUUC-Opr-071148 Ochotona princeps 47.28 3.00e-93 337.00
IUUC-Ont-071626 Oreochromis niloticus 29.41 1.00e-96 348.00
IUUC-Oan-073324 Ornithorhynchus anatinus 33.14 4.00e-56 213.00
IUUC-Ocu-074475 Oryctolagus cuniculus 47.28 2.00e-93 337.00
IUUC-Oba-075647 Oryza barthii 45.86 1.00e-41 164.00
IUUC-Olo-080577 Oryza longistaminata 44.16 4.00e-34 139.00
IUUC-Ome-081214 Oryza meridionalis 46.41 5.00e-42 165.00
IUUC-Oni-083000 Oryza nivara 45.86 1.00e-41 164.00
IUUC-Opu-083842 Oryza punctata 43.20 7.00e-42 165.00
IUUC-Oru-084361 Oryza rufipogon 45.86 1.00e-41 164.00
IUUC-Ola-086609 Oryzias latipes 48.76 7.00e-86 312.00
IUUC-Olu-087718 Ostreococcus lucimarinus 44.91 6.00e-39 156.00
IUUC-Oga-088140 Otolemur garnettii 47.85 4.00e-94 340.00
IUUC-Oar-089447 Ovis aries 47.28 5.00e-93 336.00
IUUC-Ptr-090902 Pan troglodytes 47.56 1.00e-93 338.00
IUUC-Pan-091930 Papio anubis 47.56 1.00e-93 338.00
IUUC-Psi-094059 Pelodiscus sinensis 46.97 6.00e-90 327.00
IUUC-Pma-094258 Petromyzon marinus 38.98 2.00e-41 162.00
IUUC-Pfo-096360 Poecilia formosa 47.58 8.00e-95 342.00
IUUC-Pab-098404 Pongo abelii 47.28 3.00e-93 337.00
IUUC-Pca-100949 Procavia capensis 47.85 3.00e-94 340.00
IUUC-Pva-102634 Pteropus vampyrus 47.28 3.00e-93 337.00
IUUC-Rno-105870 Rattus norvegicus 46.99 1.00e-92 335.00
IUUC-Sha-107174 Sarcophilus harrisii 46.53 2.00e-90 328.00
IUUC-Smo-109164 Selaginella moellendorffii 37.28 6.00e-38 152.00
IUUC-Sly-111176 Solanum lycopersicum 42.68 1.00e-34 141.00
IUUC-Stu-112529 Solanum tuberosum 41.88 2.00e-34 140.00
IUUC-Sar-113289 Sorex araneus 47.28 2.00e-92 334.00
IUUC-Ssc-115509 Sus scrofa 47.14 4.00e-93 337.00
IUUC-Tgu-117047 Taeniopygia guttata 46.55 2.00e-89 325.00
IUUC-Tru-118413 Takifugu rubripes 49.00 7.00e-94 339.00
IUUC-Tsy-118953 Tarsius syrichta 43.53 8.00e-74 273.00
IUUC-Tni-119794 Tetraodon nigroviridis 48.99 2.00e-93 337.00
IUUC-Tur-126725 Triticum urartu 31.93 8.00e-12 65.50
IUUC-Tbe-127825 Tupaia belangeri 47.28 3.00e-93 337.00
IUUC-Ttr-128643 Tursiops truncatus 47.11 6.00e-91 330.00
IUUC-Vpa-130660 Vicugna pacos 35.83 5.00e-49 191.00
IUUC-Vvi-131476 Vitis vinifera 50.00 2.00e-41 163.00
IUUC-Xtr-132869 Xenopus tropicalis 47.11 1.00e-91 332.00
Created Date 25-Jun-2017

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