iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033432

Ensembl Protein ID

ENSECAP00000013009.1

UniProt Accession

F6VM00; F6VM00_HORSE

Protein Name

Inhibitor of growth protein

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000015406.1	ENSECAT00000016128.1	ENSECAP00000013009.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.80e-09	36.8	226	272

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 226  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 272
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MCGCWMRRRR RRRRQQQQQQ QLYSSAALLT GERSRLLTCY VQDYLECVES LPHDMQRNVS 60
VLRELDNKYQ ETLKEIDDVY EKYKKEDDSN QKKRLQQHLQ RALINSQELG DEKIQIVTQM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCCCTCTC GAGCGGCTGC CGGTGTCCCC GCGGCGCCGG GCTGCCGAGC AGAGGAGCCG 60
CGGCGGCCGT GGCTGGTGCA TGTGTGGCTG CTGGATGCGG AGGCGGCGGC GGCGGCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	98.53	1.00e-119	422.00
IUUC-Apl-003705	Anas platyrhynchos	88.79	8.00e-91	325.00
IUUC-Aca-004990	Anolis carolinensis	81.08	3.00e-97	348.00
IUUC-Ame-011426	Astyanax mexicanus	70.80	1.00e-83	302.00
IUUC-Bta-012721	Bos taurus	98.90	2.00e-120	424.00
IUUC-Cja-018960	Callithrix jacchus	98.48	4.00e-106	377.00
IUUC-Cfa-020869	Canis familiaris	98.16	4.00e-119	420.00
IUUC-Cpo-021414	Cavia porcellus	97.06	7.00e-118	416.00
IUUC-Csa-023304	Chlorocebus sabaeus	98.53	7.00e-111	393.00
IUUC-Dre-028562	Danio rerio	68.63	2.00e-88	318.00
IUUC-Dno-029945	Dasypus novemcinctus	98.48	2.00e-115	408.00
IUUC-Dor-030141	Dipodomys ordii	97.06	1.00e-116	412.00
IUUC-Ete-032709	Echinops telfairi	97.06	6.00e-128	449.00
IUUC-Eeu-035285	Erinaceus europaeus	98.54	1.00e-90	325.00
IUUC-Fca-036467	Felis catus	98.86	2.00e-115	407.00
IUUC-Fal-036700	Ficedula albicollis	87.56	4.00e-90	323.00
IUUC-Gmo-038748	Gadus morhua	63.04	7.00e-85	306.00
IUUC-Gga-040175	Gallus gallus	88.34	9.00e-91	325.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.23	2.00e-89	322.00
IUUC-Hsa-045837	Homo sapiens	98.53	7.00e-111	393.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	98.53	1.00e-119	422.00
IUUC-Lch-049965	Latimeria chalumnae	80.92	1.00e-99	355.00
IUUC-Laf-053353	Loxodonta africana	96.89	3.00e-100	357.00
IUUC-Mcc-055155	Macaca mulatta	98.85	1.00e-72	265.00
IUUC-Meu-056470	Macropus eugenii	93.70	5.00e-111	393.00
IUUC-Mga-059570	Meleagris gallopavo	88.34	4.00e-90	323.00
IUUC-Mmr-061385	Microcebus murinus	98.90	2.00e-111	394.00
IUUC-Mdo-062144	Monodelphis domestica	93.75	2.00e-112	398.00
IUUC-Mmu-063215	Mus musculus	97.43	5.00e-119	420.00
IUUC-Mpu-065749	Mustela putorius furo	97.91	3.00e-99	354.00
IUUC-Mlu-067245	Myotis lucifugus	77.33	3.00e-82	296.00
IUUC-Nle-069968	Nomascus leucogenys	98.42	2.00e-81	295.00
IUUC-Ont-071524	Oreochromis niloticus	65.93	2.00e-86	311.00
IUUC-Ocu-074870	Oryctolagus cuniculus	99.26	1.00e-120	425.00
IUUC-Ola-087400	Oryzias latipes	89.02	5.00e-44	170.00
IUUC-Oga-088336	Otolemur garnettii	98.53	8.00e-111	392.00
IUUC-Oar-090136	Ovis aries	98.52	1.00e-118	419.00
IUUC-Ptr-091348	Pan troglodytes	98.95	4.00e-82	297.00
IUUC-Pan-092819	Papio anubis	98.53	7.00e-111	393.00
IUUC-Pfo-096633	Poecilia formosa	66.30	4.00e-80	291.00
IUUC-Pab-098346	Pongo abelii	98.16	2.00e-110	391.00
IUUC-Pca-100278	Procavia capensis	95.67	2.00e-116	410.00
IUUC-Pva-103190	Pteropus vampyrus	99.62	1.00e-116	411.00
IUUC-Rno-104940	Rattus norvegicus	97.35	5.00e-114	403.00
IUUC-Sha-107533	Sarcophilus harrisii	91.91	3.00e-113	400.00
IUUC-Sar-113630	Sorex araneus	96.59	9.00e-90	322.00
IUUC-Ssc-115734	Sus scrofa	99.62	2.00e-116	411.00
IUUC-Tgu-117034	Taeniopygia guttata	88.00	1.00e-90	325.00
IUUC-Tru-118168	Takifugu rubripes	61.68	1.00e-80	292.00
IUUC-Tsy-119494	Tarsius syrichta	99.47	1.00e-82	298.00
IUUC-Tni-120100	Tetraodon nigroviridis	61.96	1.00e-76	279.00
IUUC-Ttr-128442	Tursiops truncatus	99.02	5.00e-91	326.00
IUUC-Vpa-130063	Vicugna pacos	98.53	2.00e-119	421.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence