iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-065749

Ensembl Protein ID

ENSMPUP00000010954.1

UniProt Accession

M3YHZ7; M3YHZ7_MUSPF

Genbank Protein ID

ENSMPUP00000010954

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AEYP01043853

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000011044.1	ENSMPUT00000011137.1	ENSMPUP00000010954.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.20e-09	36.9	172	218

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 172  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 218
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MQRNVSVLRE LDNKYQETLK EIDDVYEKYK KEDDSNQKKR LQQHLQRALI NSQELGDEKI 60
QIVTQMLELV ENRARQMELH SQCFQDPAEG ERASDKAKMD SSQPERSSRR PRRQRTSESR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 60
NNNNNNNNAG CAACTGTACT CGTCGGCCGC GCTCCTGACC GGGGAGCGGA GCCGGCTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	99.58	4.00e-102	363.00
IUUC-Apl-003705	Anas platyrhynchos	88.79	9.00e-92	329.00
IUUC-Aca-004990	Anolis carolinensis	81.17	1.00e-88	319.00
IUUC-Ame-011426	Astyanax mexicanus	69.60	7.00e-74	270.00
IUUC-Bta-012721	Bos taurus	97.49	1.00e-99	355.00
IUUC-Cja-018960	Callithrix jacchus	97.07	6.00e-90	323.00
IUUC-Cfa-020869	Canis familiaris	99.16	2.00e-101	362.00
IUUC-Cpo-021414	Cavia porcellus	96.23	2.00e-98	351.00
IUUC-Csa-023304	Chlorocebus sabaeus	97.07	3.00e-90	324.00
IUUC-Dre-028562	Danio rerio	69.35	5.00e-81	293.00
IUUC-Dno-029945	Dasypus novemcinctus	97.07	3.00e-99	354.00
IUUC-Dor-030141	Dipodomys ordii	96.23	5.00e-97	347.00
IUUC-Ete-032709	Echinops telfairi	95.40	3.00e-107	381.00
IUUC-Eca-033432	Equus caballus	97.91	1.00e-99	355.00
IUUC-Eeu-035285	Erinaceus europaeus	97.56	4.00e-90	323.00
IUUC-Fca-036467	Felis catus	99.16	3.00e-101	361.00
IUUC-Fal-036700	Ficedula albicollis	87.56	5.00e-91	327.00
IUUC-Gmo-038748	Gadus morhua	62.55	6.00e-76	276.00
IUUC-Gga-040175	Gallus gallus	88.34	2.00e-91	328.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.66	6.00e-81	293.00
IUUC-Hsa-045837	Homo sapiens	97.07	3.00e-90	324.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	97.49	4.00e-99	353.00
IUUC-Lch-049965	Latimeria chalumnae	81.59	6.00e-91	326.00
IUUC-Laf-053353	Loxodonta africana	95.56	2.00e-99	354.00
IUUC-Mcc-055155	Macaca mulatta	97.13	7.00e-72	262.00
IUUC-Meu-056470	Macropus eugenii	92.05	2.00e-101	362.00
IUUC-Mga-059570	Meleagris gallopavo	88.34	7.00e-91	326.00
IUUC-Mmr-061385	Microcebus murinus	97.49	1.00e-90	326.00
IUUC-Mdo-062144	Monodelphis domestica	92.47	6.00e-102	363.00
IUUC-Mmu-063215	Mus musculus	96.23	9.00e-99	352.00
IUUC-Nle-069968	Nomascus leucogenys	96.84	2.00e-80	291.00
IUUC-Ont-071524	Oreochromis niloticus	66.53	7.00e-78	283.00
IUUC-Ocu-074870	Oryctolagus cuniculus	98.33	3.00e-100	357.00
IUUC-Ola-087400	Oryzias latipes	89.02	3.00e-44	171.00
IUUC-Oga-088336	Otolemur garnettii	97.07	3.00e-90	324.00
IUUC-Oar-090136	Ovis aries	97.07	3.00e-99	354.00
IUUC-Ptr-091348	Pan troglodytes	97.37	3.00e-81	294.00
IUUC-Pan-092819	Papio anubis	97.07	3.00e-90	324.00
IUUC-Psi-093854	Pelodiscus sinensis	85.63	3.00e-62	230.00
IUUC-Pfo-096633	Poecilia formosa	66.67	1.00e-71	263.00
IUUC-Pab-098346	Pongo abelii	97.07	4.00e-90	324.00
IUUC-Pca-100278	Procavia capensis	94.56	2.00e-106	377.00
IUUC-Pva-103190	Pteropus vampyrus	98.33	4.00e-100	357.00
IUUC-Rno-104940	Rattus norvegicus	95.82	1.00e-97	348.00
IUUC-Sha-107533	Sarcophilus harrisii	92.05	1.00e-102	365.00
IUUC-Sar-113630	Sorex araneus	96.59	1.00e-90	325.00
IUUC-Ssc-115734	Sus scrofa	98.33	5.00e-100	357.00
IUUC-Tgu-117034	Taeniopygia guttata	88.00	1.00e-91	328.00
IUUC-Tru-118168	Takifugu rubripes	61.45	9.00e-72	263.00
IUUC-Tsy-119494	Tarsius syrichta	97.89	9.00e-82	296.00
IUUC-Tni-120100	Tetraodon nigroviridis	62.61	5.00e-68	250.00
IUUC-Ttr-128442	Tursiops truncatus	97.56	3.00e-90	323.00
IUUC-Vpa-130063	Vicugna pacos	97.49	1.00e-99	355.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence