iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098346

Ensembl Protein ID

ENSPPYP00000017012.2

UniProt Accession

H2PEU1; H2PEU1_PONAB

Genbank Protein ID

ENSPPYP00000017012

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

ABGA01318313

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000015229.2	ENSPPYT00000017702.2	ENSPPYP00000017012.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.00e-09	36.6	213	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 213  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 259
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 60
KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAGAATG CGAACCCTCC GGTAGGCGGT AGGGGCGGGG CCCGGCCTTA TTCGGAGCGA 60
GCGCTGCGCA GGCGCAGAGG CGGCCGCGGG CGGAGGGGCG GGGGCAGGCT AGCGGGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

KEGG

pon:100460486

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	97.86	5.00e-120	423.00
IUUC-Apl-003705	Anas platyrhynchos	89.24	2.00e-91	328.00
IUUC-Aca-004990	Anolis carolinensis	81.47	9.00e-98	349.00
IUUC-Ame-011426	Astyanax mexicanus	71.17	4.00e-84	303.00
IUUC-Bta-012721	Bos taurus	96.82	9.00e-119	419.00
IUUC-Cja-018960	Callithrix jacchus	98.86	2.00e-107	381.00
IUUC-Cfa-020869	Canis familiaris	97.50	2.00e-119	421.00
IUUC-Cpo-021414	Cavia porcellus	95.71	2.00e-117	415.00
IUUC-Csa-023304	Chlorocebus sabaeus	99.64	1.00e-114	405.00
IUUC-Dre-028562	Danio rerio	69.96	3.00e-88	317.00
IUUC-Dno-029945	Dasypus novemcinctus	97.35	5.00e-114	403.00
IUUC-Dor-030141	Dipodomys ordii	96.07	1.00e-116	412.00
IUUC-Ete-032709	Echinops telfairi	95.41	2.00e-127	448.00
IUUC-Eca-033432	Equus caballus	98.16	2.00e-118	418.00
IUUC-Eeu-035285	Erinaceus europaeus	98.53	4.00e-90	323.00
IUUC-Fca-036467	Felis catus	98.11	4.00e-114	403.00
IUUC-Fal-036700	Ficedula albicollis	88.00	1.00e-90	325.00
IUUC-Gmo-038748	Gadus morhua	63.04	3.00e-85	308.00
IUUC-Gga-040175	Gallus gallus	88.79	3.00e-91	327.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.23	3.00e-89	320.00
IUUC-Hsa-045837	Homo sapiens	99.64	1.00e-114	405.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	98.21	1.00e-120	425.00
IUUC-Lch-049965	Latimeria chalumnae	81.30	4.00e-100	357.00
IUUC-Laf-053353	Loxodonta africana	96.44	6.00e-100	356.00
IUUC-Mcc-055155	Macaca mulatta	99.43	5.00e-74	269.00
IUUC-Meu-056470	Macropus eugenii	93.70	3.00e-111	394.00
IUUC-Mga-059570	Meleagris gallopavo	88.79	1.00e-90	325.00
IUUC-Mmr-061385	Microcebus murinus	99.29	3.00e-114	404.00
IUUC-Mdo-062144	Monodelphis domestica	93.75	1.00e-112	399.00
IUUC-Mmu-063215	Mus musculus	96.09	1.00e-117	415.00
IUUC-Mpu-065749	Mustela putorius furo	97.07	8.00e-98	349.00
IUUC-Mlu-067245	Myotis lucifugus	75.00	6.00e-81	293.00
IUUC-Nle-069968	Nomascus leucogenys	98.95	1.00e-82	299.00
IUUC-Ont-071524	Oreochromis niloticus	66.30	2.00e-86	311.00
IUUC-Ocu-074870	Oryctolagus cuniculus	97.88	4.00e-120	423.00
IUUC-Ola-087400	Oryzias latipes	89.02	2.00e-44	172.00
IUUC-Oga-088336	Otolemur garnettii	97.88	4.00e-112	397.00
IUUC-Oar-090136	Ovis aries	97.41	4.00e-117	413.00
IUUC-Ptr-091348	Pan troglodytes	99.47	2.00e-83	301.00
IUUC-Pan-092819	Papio anubis	99.64	1.00e-114	405.00
IUUC-Psi-093854	Pelodiscus sinensis	86.78	1.00e-63	234.00
IUUC-Pfo-096633	Poecilia formosa	63.79	2.00e-80	291.00
IUUC-Pca-100278	Procavia capensis	96.06	4.00e-117	413.00
IUUC-Pva-103190	Pteropus vampyrus	98.48	8.00e-115	406.00
IUUC-Rno-104940	Rattus norvegicus	96.21	2.00e-112	397.00
IUUC-Sha-107533	Sarcophilus harrisii	91.91	1.00e-113	402.00
IUUC-Sar-113630	Sorex araneus	96.08	1.00e-88	318.00
IUUC-Ssc-115734	Sus scrofa	98.48	8.00e-115	406.00
IUUC-Tgu-117034	Taeniopygia guttata	88.44	3.00e-91	327.00
IUUC-Tru-118168	Takifugu rubripes	60.34	1.00e-81	295.00
IUUC-Tsy-119494	Tarsius syrichta	99.02	7.00e-83	299.00
IUUC-Tni-120100	Tetraodon nigroviridis	61.25	5.00e-77	280.00
IUUC-Ttr-128442	Tursiops truncatus	98.04	1.00e-89	322.00
IUUC-Vpa-130063	Vicugna pacos	97.50	1.00e-119	422.00
IUUC-Xtr-132348	Xenopus tropicalis	70.00	1.00e-68	253.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence