iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198690.9	ENST00000561594.5	ENSP00000455983.1
ENSG00000198690.9	ENST00000565280.5	ENSP00000455573.1
ENSG00000198690.9	ENST00000562892.1	ENSP00000457680.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/UBZ	3.50e-09	38.4	41	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 1    llvCPvCqkmvdqtdfeeHlDe.C 23
           +l CPvC+kmv+++d+++HlDe C
   Q: 41   KLACPVCSKMVPRYDLNRHLDEmC 64
           689******************988 PP

Organism

Homo sapiens

Functional Description
(View)

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed:20603015, PubMed:20603016, PubMed:20603073, PubMed:20671156, PubMed:24981866, PubMed:25430771). Not involved in DNA double-strand breaks resection (PubMed:20603015, PubMed:20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed:25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed:25430771). Also has endonuclease activity toward 5'-flaps (PubMed:20603015, PubMed:20603016, PubMed:24981866).

Protein Sequence
(Fasta)

MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM VPRYDLNRHL 60
DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK KSPPPKTNLT PGQSDSAKRE 120

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Nucleotide Sequence
(Fasta)

CTGGGAATGC CTGGAAGCGC CGGCGCGCGG AGCCAGGTGG GAGGTGCGAG GTGGCCGCGC 60
GGGGATCTTG GGTGACAGGG CACCGAGGGA AGGAGGACGC GAGGGCAGCC AGGCCCTAGG 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0255--Endonuclease
KW-0269--Exonuclease
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033315--Fan1-like
IPR011990--TPR-like_helical_dom
IPR014883--VRR_NUC
IPR006642--Znf_Rad18_put

Pfam

PF08774--VRR_NUC

SMART

SM00990--VRR_NUC
SM00734--ZnF_Rad18

Gene Ontology

GO:0005829--C:cytosol
GO:0045171--C:intercellular bridge
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0000287--F:magnesium ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0043130--F:ubiquitin binding
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0036297--P:interstrand cross-link repair
GO:0006289--P:nucleotide-excision repair
GO:0033683--P:nucleotide-excision repair, DNA incision

KEGG

hsa:22909

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence