iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063388

UUCD1 version

UUC-MuM-00029

Ensembl Protein ID

ENSMUSP00000105887.1

UniProt Accession

Q6NZQ8; Q3U7M8; Q3UVF8; Q8C294; Q8CBA1; MARH1_MOUSE

Genbank Protein ID

BAC29449.1; BAC40715.1; BAE23311.1; BAE31341.1; BAE37183.1; AAH66008.1

Protein Name

E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; RING-type E3 ubiquitin transferase MARCH1

Genbank Nucleotide ID

AK036489; AK089040; AK137337; AK152592; AK163081; BC066008

Gene Name

1-Mar

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000036469.16	ENSMUST00000110258.7	ENSMUSP00000105887.1
ENSMUSG00000036469.16	ENSMUST00000110256.7	ENSMUSP00000105885.1
ENSMUSG00000036469.16	ENSMUST00000110255.7	ENSMUSP00000105884.1
ENSMUSG00000036469.16	ENSMUST00000110259.7	ENSMUSP00000105888.1
ENSMUSG00000036469.16	ENSMUST00000039540.11	ENSMUSP00000044070.5
ENSMUSG00000036469.16	ENSMUST00000110253.2	ENSMUSP00000105882.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19117940

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	3.1	9.5	80	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf.kdgplvlpCgHv....f.hadClqkwpglknssskefrCPlCr 46
           C iC+++  ++ pl++pC  +    f h++Cl++w     +ss +  C lC+
   Q: 80   CRICHCEGdEESPLITPCRCTgtlrFvHQSCLHQW----IKSSDTRCCELCK 127
           ****88774444******876778855********....8899999*****6 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.

Protein Sequence
(Fasta)

MLGWCEAIAR NPHRIPNTTR TPETSGDVAD ASQTSTLNEK SPGRSASRSS NISKASSPTT 60
GTAPRSQSRL SVCPSTQDIC RICHCEGDEE SPLITPCRCT GTLRFVHQSC LHQWIKSSDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGTGCTGGA TTATTCCAGT TTTTGAGCAT GGCAGATTTC CACTGGATGA CATCATGGGA 60
GCCCAGTGAG TGCCGCTGGT GGAGGGGGAC AGAGAAGGGG AGGAGGCTCA GAGGAGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0391--Immunity
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005789--C:endoplasmic reticulum membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0005886--C:plasma membrane
GO:0032588--C:trans-Golgi network membrane
GO:0042287--F:MHC protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002495--P:antigen processing and presentation of peptide antigen via MHC class II
GO:0006955--P:immune response
GO:0000209--P:protein polyubiquitination

KEGG

mmu:72925

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001621	Ailuropoda melanoleuca	94.12	1.00e-152	531.00
IUUC-Aca-004316	Anolis carolinensis	84.83	3.00e-148	517.00
IUUC-Cja-019593	Callithrix jacchus	94.46	3.00e-152	530.00
IUUC-Cfa-020376	Canis familiaris	95.20	2.00e-142	498.00
IUUC-Cpo-021447	Cavia porcellus	94.12	1.00e-151	528.00
IUUC-Cho-024995	Choloepus hoffmanni	98.48	5.00e-74	269.00
IUUC-Cin-025566	Ciona intestinalis	45.22	1.00e-16	79.70
IUUC-Dor-030770	Dipodomys ordii	76.47	3.00e-114	404.00
IUUC-Eeu-034876	Erinaceus europaeus	91.70	5.00e-161	559.00
IUUC-Fca-035915	Felis catus	95.16	9.00e-154	535.00
IUUC-Gga-041073	Gallus gallus	87.59	4.00e-151	526.00
IUUC-Ggo-045247	Gorilla gorilla	95.50	2.00e-154	538.00
IUUC-Hsa-046201	Homo sapiens	95.50	2.00e-154	538.00
IUUC-Lch-049814	Latimeria chalumnae	88.48	4.00e-115	407.00
IUUC-Mcc-055170	Macaca mulatta	94.81	3.00e-153	533.00
IUUC-Meu-056594	Macropus eugenii	74.74	2.00e-63	235.00
IUUC-Mga-059662	Meleagris gallopavo	86.96	6.00e-130	456.00
IUUC-Mmr-060572	Microcebus murinus	94.81	2.00e-153	534.00
IUUC-Mdo-062427	Monodelphis domestica	92.77	4.00e-131	460.00
IUUC-Nle-069120	Nomascus leucogenys	95.50	2.00e-154	538.00
IUUC-Oan-072984	Ornithorhynchus anatinus	90.31	6.00e-158	549.00
IUUC-Ocu-074267	Oryctolagus cuniculus	93.43	4.00e-151	526.00
IUUC-Ptr-090476	Pan troglodytes	95.16	6.00e-153	533.00
IUUC-Pan-092390	Papio anubis	95.24	8.00e-133	466.00
IUUC-Psi-093584	Pelodiscus sinensis	88.24	5.00e-152	530.00
IUUC-Pca-100362	Procavia capensis	69.55	2.00e-101	361.00
IUUC-Rno-106041	Rattus norvegicus	99.57	8.00e-137	479.00
IUUC-Sha-107488	Sarcophilus harrisii	92.04	2.00e-148	517.00
IUUC-Sar-113258	Sorex araneus	92.99	5.00e-139	486.00
IUUC-Sbi-113840	Sorghum bicolor	29.68	6.00e-10	57.80
IUUC-Tgu-116539	Taeniopygia guttata	87.59	3.00e-151	527.00
IUUC-Tsy-119324	Tarsius syrichta	93.79	3.00e-150	524.00
IUUC-Tbe-127567	Tupaia belangeri	91.77	2.00e-128	451.00
IUUC-Ttr-129098	Tursiops truncatus	90.69	6.00e-133	466.00
IUUC-Vpa-130287	Vicugna pacos	74.05	2.00e-106	378.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence