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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063540
UUCD1 version UUC-MuM-00198
Ensembl Protein ID ENSMUSP00000028603.3
UniProt Accession Q9DC63; A2BHN5; A2BHN7; Q3TKB0; Q3U9C1; Q8C7I0; Q8CEJ0; Q91VI9; Q9D2J5; Q9JIE4; FBX3_MOUSE
Genbank Protein ID AAF67156.1; BAB23360.1; BAB31793.1; BAC25719.1; BAC27398.1; BAC33965.1; BAC34118.1; BAE30138.1; BAE30746.1; BAE31491.1; BAE39235.1; CAM18978.1; CAM18980.1; CAM18981.1; EDL27711.1; EDL27712.1; AAH10212.2; AAH58253.1
Protein Name F-box only protein 3
Genbank Nucleotide ID AF233226; AK004544; AK019550; AK028048; AK031428; AK049870; AK050195; AK151130; AK151857; AK152780; AK167075; BX640578; BX640578; BX640578; CH466519; CH466519; BC010212; BC058253
Gene Name Fbxo3; Fba; Fbx3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027180.12 ENSMUST00000028603.9 ENSMUSP00000028603.3
ENSMUSG00000027180.12 ENSMUST00000102565.3 ENSMUSP00000099625.3
ENSMUSG00000027180.12 ENSMUST00000111135.7 ENSMUSP00000106765.1
ENSMUSG00000027180.12 ENSMUST00000111136.7 ENSMUSP00000106766.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 95.92 0.00e+00 789.00 IUUC-Hsa-047002
E3 adaptor/Cullin RING/SCF/F-box 36.36 5.00e-04 40.80 IUUC-Sce-106220
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).
 Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity).
Protein Sequence
(Fasta)
MAAVEAETGL LTLESLPTDP LLLILSFVDY RDLINCCYVS RRLSQLSTHD PLWRRHCKKY 60
WLISEEEKAG KSQCWRSLFI ETYSDVGRYI DHYAAIKKAW RDLKKYLEPR CPRMVLSLKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063540|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GGTGGGCGGG GCATCCCGGG GGCGGGGCTG GGGCCGGGTG ACAGTTACAT AACTAACCTG 60
TGCTAGCGGC CGCCGAGCGG TTCGGGCGGC GGGGGCGGGG GCGGGGCCGG GGTGGTGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063540|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR007474--ApaG_domain
IPR001810--F-box_dom
IPR018958--SMI1/KNR4-like_dom
PROSITE

PS51087--APAG
PS50181--FBOX
Pfam

PF04379--DUF525
PF12937--F-box-like
PF09346--SMI1_KNR4
SMART

SM00256--FBOX
SM00860--SMI1_KNR4
Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
KEGG mmu:57443
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001541 Ailuropoda melanoleuca 97.01 0.00e+00 772.00
IUUC-Afl-008734 Aspergillus flavus 31.25 5.00e-04 39.30
IUUC-Ani-009404 Aspergillus nidulans 31.25 5.00e-04 39.30
IUUC-Ang-009604 Aspergillus niger 32.76 1.00e-04 41.60
IUUC-Aor-009932 Aspergillus oryzae 31.25 4.00e-04 39.70
IUUC-Bta-013260 Bos taurus 95.20 0.00e+00 786.00
IUUC-Bdi-014986 Brachypodium distachyon 24.29 3.00e-13 69.70
IUUC-Bol-015263 Brassica oleracea 26.54 7.00e-19 88.20
IUUC-Cja-019627 Callithrix jacchus 95.92 0.00e+00 792.00
IUUC-Cfa-020598 Canis familiaris 95.68 0.00e+00 791.00
IUUC-Cpo-021355 Cavia porcellus 96.52 0.00e+00 766.00
IUUC-Csa-023967 Chlorocebus sabaeus 95.68 0.00e+00 790.00
IUUC-Cin-025228 Ciona intestinalis 33.25 1.00e-46 180.00
IUUC-Csv-026017 Ciona savignyi 30.45 9.00e-49 187.00
IUUC-Dno-029157 Dasypus novemcinctus 98.68 8.00e-167 579.00
IUUC-Dor-030275 Dipodomys ordii 95.82 0.00e+00 725.00
IUUC-Ete-032638 Echinops telfairi 92.57 1.00e-151 529.00
IUUC-Eca-034324 Equus caballus 94.44 0.00e+00 737.00
IUUC-Eeu-034676 Erinaceus europaeus 81.84 0.00e+00 640.00
IUUC-Fca-035703 Felis catus 95.68 0.00e+00 791.00
IUUC-Fso-038271 Fusarium solani 36.21 7.00e-06 45.40
IUUC-Ggo-044501 Gorilla gorilla 95.92 0.00e+00 791.00
IUUC-Hsa-047002 Homo sapiens 95.92 0.00e+00 791.00
IUUC-Itr-048749 Ictidomys tridecemlineatus 98.68 8.00e-167 579.00
IUUC-Laf-054310 Loxodonta africana 95.92 0.00e+00 792.00
IUUC-Mcc-055406 Macaca mulatta 95.68 0.00e+00 791.00
IUUC-Mmr-061614 Microcebus murinus 95.40 0.00e+00 781.00
IUUC-Mpu-066040 Mustela putorius furo 95.68 0.00e+00 791.00
IUUC-Mlu-067763 Myotis lucifugus 88.80 0.00e+00 796.00
IUUC-Nfi-068290 Neosartorya fischeri 32.81 9.00e-05 42.00
IUUC-Nle-069186 Nomascus leucogenys 95.92 0.00e+00 791.00
IUUC-Opr-070860 Ochotona princeps 82.91 1.00e-79 290.00
IUUC-Ocu-074378 Oryctolagus cuniculus 71.88 2.00e-61 228.00
IUUC-Oba-075362 Oryza barthii 24.71 1.00e-12 67.00
IUUC-Ogl-077469 Oryza glaberrima 23.66 2.00e-11 63.90
IUUC-Oin-079080 Oryza indica 22.95 1.00e-10 61.20
IUUC-Ome-081119 Oryza meridionalis 23.93 5.00e-12 65.90
IUUC-Opu-084117 Oryza punctata 23.46 2.00e-11 63.50
IUUC-Osa-085783 Oryza sativa 22.95 1.00e-10 61.20
IUUC-Oga-088925 Otolemur garnettii 95.20 0.00e+00 785.00
IUUC-Oar-090074 Ovis aries 95.44 0.00e+00 789.00
IUUC-Ptr-091462 Pan troglodytes 95.92 0.00e+00 791.00
IUUC-Pan-092326 Papio anubis 95.68 0.00e+00 791.00
IUUC-Psi-093898 Pelodiscus sinensis 86.71 1.00e-146 512.00
IUUC-Pab-097597 Pongo abelii 95.92 0.00e+00 791.00
IUUC-Pva-102622 Pteropus vampyrus 96.16 0.00e+00 793.00
IUUC-Rno-105168 Rattus norvegicus 98.32 0.00e+00 805.00
IUUC-Sce-106220 Saccharomyces cerevisiae 36.36 2.00e-04 40.80
IUUC-Sit-110738 Setaria italica 24.00 4.00e-09 56.20
IUUC-Stu-112725 Solanum tuberosum 27.72 1.00e-04 40.80
IUUC-Ssc-115881 Sus scrofa 94.80 2.00e-155 540.00
IUUC-Tca-121476 Theobroma cacao 25.55 3.00e-17 83.20
IUUC-Tur-126848 Triticum urartu 24.72 2.00e-13 70.10
IUUC-Ttr-128934 Tursiops truncatus 95.58 0.00e+00 684.00
IUUC-Vpa-130081 Vicugna pacos 97.12 0.00e+00 734.00
Created Date 25-Jun-2017

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