iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	9.50e-09	35.2	102	164
E3 activity/RING/RING	5.70e-08	33.2	104	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqpl.teedlvPnltlrrliqa 67
           + C+I  +  ++Pv +++G+ + rs++  w++++++ cP+++++l +e+d+ P +  rr i++
   Q: 102  YECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLsAEHDIFPDNYTRREIEQ 164
           78*******************************************888999999999888875 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC + + + p++++CgH f+++Cl +w     ++++++ CP +
   Q: 104  CAICIDWLNE-PVLTSCGHRFCRSCLTAW-----MQKNNQCCPMD 142
           ********99.999***************.....68888889976 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MQRVQADQKP ARMHQHAHTH SHAHSLQHAE EKEHNSNEMT TNLSSTGRIA ASSSATPSAA 60
AGGGASGAPT PPKSLALNQN HHYAPGSDTS GEQEEELLDS RYECAICIDW LNEPVLTSCG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGTGTTGC ACAATCCTCG TTGGATACAC AGCTGTTCCG CGGAGTCATG AACGAAAATT 60
ATTATTAAAA TTGAATTAGT TGATTCAAAG AGGATAGCCA GCAGGCGGCC AGAGGAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR008974--TRAF-like
IPR027138--TRAF4
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0008219--P:cell death
GO:0007391--P:dorsal closure
GO:0045087--P:innate immune response
GO:0045746--P:negative regulation of Notch signaling pathway
GO:0010508--P:positive regulation of autophagy
GO:0046330--P:positive regulation of JNK cascade
GO:0000209--P:protein polyubiquitination
GO:0050688--P:regulation of defense response to virus
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0031098--P:stress-activated protein kinase signaling cascade
GO:0008063--P:Toll signaling pathway

KEGG

dme:Dmel_CG10961

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000439	Aegilops tauschii	26.67	2.00e-08	53.50
IUUC-Aml-001262	Ailuropoda melanoleuca	26.55	1.00e-37	149.00
IUUC-Apl-004062	Anas platyrhynchos	27.90	2.00e-41	162.00
IUUC-Aca-004636	Anolis carolinensis	25.90	3.00e-38	152.00
IUUC-Ame-011682	Astyanax mexicanus	27.23	2.00e-35	142.00
IUUC-Bta-012692	Bos taurus	27.39	2.00e-43	169.00
IUUC-Cja-019426	Callithrix jacchus	26.71	2.00e-38	152.00
IUUC-Cfa-020948	Canis familiaris	26.54	5.00e-35	141.00
IUUC-Cpo-021378	Cavia porcellus	27.41	3.00e-41	162.00
IUUC-Csa-024045	Chlorocebus sabaeus	26.93	5.00e-40	157.00
IUUC-Cho-024532	Choloepus hoffmanni	22.96	3.00e-11	62.80
IUUC-Cin-025234	Ciona intestinalis	26.90	4.00e-16	79.00
IUUC-Csv-026300	Ciona savignyi	35.46	1.00e-13	68.90
IUUC-Dre-027557	Danio rerio	25.81	1.00e-36	146.00
IUUC-Dno-030032	Dasypus novemcinctus	38.24	7.00e-16	77.00
IUUC-Dor-030790	Dipodomys ordii	27.06	3.00e-39	155.00
IUUC-Ete-032952	Echinops telfairi	27.87	9.00e-26	110.00
IUUC-Eca-033924	Equus caballus	30.73	8.00e-25	107.00
IUUC-Eeu-034734	Erinaceus europaeus	25.61	4.00e-36	145.00
IUUC-Fca-036222	Felis catus	28.16	2.00e-40	159.00
IUUC-Fal-036834	Ficedula albicollis	26.33	8.00e-34	137.00
IUUC-Gmo-039061	Gadus morhua	30.00	3.00e-21	95.90
IUUC-Gga-040599	Gallus gallus	27.65	9.00e-43	167.00
IUUC-Gac-041977	Gasterosteus aculeatus	27.41	4.00e-39	155.00
IUUC-Ggo-044508	Gorilla gorilla	25.16	6.00e-39	154.00
IUUC-Hsa-046349	Homo sapiens	26.52	1.00e-39	156.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	27.86	8.00e-43	167.00
IUUC-Lch-049821	Latimeria chalumnae	28.45	2.00e-45	176.00
IUUC-Loc-051995	Lepisosteus oculatus	32.61	9.00e-25	107.00
IUUC-Laf-054115	Loxodonta africana	27.86	4.00e-44	171.00
IUUC-Mcc-055298	Macaca mulatta	26.93	9.00e-40	157.00
IUUC-Meu-056101	Macropus eugenii	25.81	6.00e-09	53.50
IUUC-Mor-057263	Magnaporthe oryzae	28.57	4.00e-10	58.90
IUUC-Mga-059340	Meleagris gallopavo	27.65	1.00e-42	167.00
IUUC-Mmr-061063	Microcebus murinus	27.17	4.00e-42	165.00
IUUC-Mdo-062075	Monodelphis domestica	27.39	3.00e-45	175.00
IUUC-Mmu-063780	Mus musculus	27.77	8.00e-41	160.00
IUUC-Mpu-065748	Mustela putorius furo	26.96	8.00e-38	150.00
IUUC-Mlu-067888	Myotis lucifugus	28.73	7.00e-43	167.00
IUUC-Nle-069234	Nomascus leucogenys	26.52	1.00e-39	156.00
IUUC-Opr-070393	Ochotona princeps	30.81	3.00e-22	98.60
IUUC-Ont-072459	Oreochromis niloticus	27.20	3.00e-40	159.00
IUUC-Oan-073578	Ornithorhynchus anatinus	27.62	4.00e-45	174.00
IUUC-Ocu-074201	Oryctolagus cuniculus	27.41	6.00e-41	161.00
IUUC-Ome-081268	Oryza meridionalis	33.33	3.00e-07	49.70
IUUC-Ola-087319	Oryzias latipes	33.33	9.00e-20	90.90
IUUC-Oga-087936	Otolemur garnettii	27.17	6.00e-41	161.00
IUUC-Oar-089379	Ovis aries	27.39	2.00e-43	169.00
IUUC-Ptr-090758	Pan troglodytes	26.52	1.00e-39	156.00
IUUC-Pan-092590	Papio anubis	26.93	7.00e-40	157.00
IUUC-Psi-093948	Pelodiscus sinensis	27.55	2.00e-42	166.00
IUUC-Pma-094434	Petromyzon marinus	28.11	1.00e-17	83.60
IUUC-Pfo-096912	Poecilia formosa	26.11	7.00e-41	160.00
IUUC-Pab-097651	Pongo abelii	26.52	1.00e-39	157.00
IUUC-Pca-100958	Procavia capensis	26.90	4.00e-27	114.00
IUUC-Ppe-101406	Prunus persica	29.07	3.00e-08	52.40
IUUC-Pva-103247	Pteropus vampyrus	40.50	8.00e-16	77.80
IUUC-Rno-104994	Rattus norvegicus	27.43	3.00e-43	169.00
IUUC-Sha-106494	Sarcophilus harrisii	26.80	1.00e-45	176.00
IUUC-Sar-113375	Sorex araneus	26.30	1.00e-40	159.00
IUUC-Ssc-115417	Sus scrofa	26.74	2.00e-43	169.00
IUUC-Tgu-117232	Taeniopygia guttata	26.93	6.00e-38	151.00
IUUC-Tru-118321	Takifugu rubripes	24.73	1.00e-36	146.00
IUUC-Tni-120475	Tetraodon nigroviridis	25.71	1.00e-36	147.00
IUUC-Tae-123841	Triticum aestivum	28.57	2.00e-08	53.50
IUUC-Tur-126448	Triticum urartu	28.57	4.00e-08	52.80
IUUC-Tbe-127719	Tupaia belangeri	27.83	1.00e-27	117.00
IUUC-Ttr-129264	Tursiops truncatus	38.97	2.00e-16	80.10
IUUC-Vpa-130244	Vicugna pacos	40.35	7.00e-19	87.80
IUUC-Xtr-131948	Xenopus tropicalis	25.60	1.00e-38	153.00
IUUC-Xma-133132	Xiphophorus maculatus	26.11	2.00e-39	156.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence