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Tag Content
iUUCD ID IUUC-Stu-112433
Ensembl Protein ID PGSC0003DMT400072494
UniProt Accession M1CQE1; M1CQE1_SOLTU
Protein Name Presenilin
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
PGSC0003DMG400028205 PGSC0003DMT400072494 PGSC0003DMT400072494
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/CUE 32.94 6.00e-37 151.00 IUUC-Cel-018553
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Solanum tuberosum
Functional Description
(View)

Functional Description


     Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
 Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.
Protein Sequence
(Fasta)
MDGGSILETI GVEIIGVMSP VSICMFLVVL IVYTLSSPSS SDNQQVIRTA ANLIYLESSS 60
DTTTQKLEGA LLNAVVFVVL ITLVTFLLVI LYYYRFTNFL KYYIRFSAFF VLGSMGGSIF 120
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Protein Fasta Sequence


>IUUC-Stu-112433|UBD,CUE|Solanum tuberosum
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Nucleotide Sequence
(Fasta)
CAAAATTCAG TTTCTGTTGT GATTTTCCAA ACAGACCTTA AAAAAATTCA CCATCCCAAA 60
CCTCACCACC GGCCGGAGAC CCGAAAATGG ACGGCGGCAG CATTCTGGAG ACGATCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Stu-112433|UBD,CUE|Solanum tuberosum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
Interpro

IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP
Pfam

PF01080--Presenilin
PRINTS

PR01072--PRESENILIN
SMART

SM00730--PSN
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005798--C:Golgi-associated vesicle
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing
KEGG sot:102605567
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000686 Aegilops tauschii 55.86 3.00e-89 322.00
IUUC-Aml-001648 Ailuropoda melanoleuca 35.31 9.00e-37 146.00
IUUC-Atr-003039 Amborella trichopoda 59.91 2.00e-135 474.00
IUUC-Apl-003727 Anas platyrhynchos 34.67 6.00e-38 150.00
IUUC-Aca-004582 Anolis carolinensis 34.28 7.00e-38 150.00
IUUC-Aly-005455 Arabidopsis lyrata 74.45 4.00e-81 294.00
IUUC-Ath-006730 Arabidopsis thaliana 60.35 1.00e-120 425.00
IUUC-Ame-010686 Astyanax mexicanus 32.68 3.00e-39 154.00
IUUC-Bta-013026 Bos taurus 34.04 5.00e-40 157.00
IUUC-Bdi-014196 Brachypodium distachyon 55.31 2.00e-95 342.00
IUUC-Bol-015841 Brassica oleracea 60.49 4.00e-115 407.00
IUUC-Bra-017580 Brassica rapa 58.19 9.00e-103 365.00
IUUC-Cel-018553 Caenorhabditis elegans 34.27 4.00e-49 187.00
IUUC-Cja-019994 Callithrix jacchus 34.52 1.00e-40 159.00
IUUC-Cfa-020074 Canis familiaris 34.28 1.00e-41 162.00
IUUC-Cpo-022237 Cavia porcellus 35.22 3.00e-42 164.00
IUUC-Cre-022747 Chlamydomonas reinhardtii 43.10 1.00e-51 196.00
IUUC-Csa-023537 Chlorocebus sabaeus 34.67 2.00e-41 162.00
IUUC-Cho-024735 Choloepus hoffmanni 32.70 8.00e-40 156.00
IUUC-Cin-025780 Ciona intestinalis 32.44 7.00e-45 173.00
IUUC-Csv-025967 Ciona savignyi 32.52 4.00e-42 164.00
IUUC-Cme-027279 Cyanidioschyzon merolae 29.51 3.10e-01 28.90
IUUC-Dre-028689 Danio rerio 33.09 9.00e-38 149.00
IUUC-Dno-029758 Dasypus novemcinctus 33.65 1.00e-40 159.00
IUUC-Dor-031127 Dipodomys ordii 33.79 3.00e-25 108.00
IUUC-Dme-031929 Drosophila melanogaster 32.23 1.00e-44 173.00
IUUC-Ete-032487 Echinops telfairi 40.00 2.00e-20 92.40
IUUC-Eca-034387 Equus caballus 33.33 4.00e-28 117.00
IUUC-Eeu-035134 Erinaceus europaeus 37.30 1.00e-36 145.00
IUUC-Fca-036243 Felis catus 34.28 2.00e-41 162.00
IUUC-Fal-036600 Ficedula albicollis 33.09 4.00e-37 147.00
IUUC-Gmo-038550 Gadus morhua 34.45 5.00e-28 117.00
IUUC-Gga-040993 Gallus gallus 33.33 4.00e-38 151.00
IUUC-Gac-042511 Gasterosteus aculeatus 32.31 3.00e-37 148.00
IUUC-Gma-043822 Glycine max 69.23 2.00e-53 201.00
IUUC-Ggo-044859 Gorilla gorilla 32.99 9.00e-30 123.00
IUUC-Hsa-046822 Homo sapiens 34.67 2.00e-41 162.00
IUUC-Hvu-047141 Hordeum vulgare 55.63 6.00e-96 343.00
IUUC-Itr-048420 Ictidomys tridecemlineatus 35.61 3.00e-38 150.00
IUUC-Lch-049638 Latimeria chalumnae 29.16 2.00e-31 129.00
IUUC-Lpe-051132 Leersia perrieri 53.95 5.00e-92 330.00
IUUC-Loc-052427 Lepisosteus oculatus 32.62 5.00e-42 164.00
IUUC-Laf-053979 Loxodonta africana 35.24 8.00e-38 150.00
IUUC-Mcc-055682 Macaca mulatta 34.67 2.00e-41 162.00
IUUC-Meu-056004 Macropus eugenii 30.72 1.00e-28 119.00
IUUC-Mtr-058392 Medicago truncatula 65.97 8.00e-120 422.00
IUUC-Mga-059466 Meleagris gallopavo 34.13 4.00e-38 150.00
IUUC-Mmr-060890 Microcebus murinus 33.79 4.00e-29 121.00
IUUC-Mdo-062122 Monodelphis domestica 35.08 1.00e-41 162.00
IUUC-Mmu-063176 Mus musculus 33.57 7.00e-39 153.00
IUUC-Mac-064858 Musa acuminata 89.41 2.00e-40 157.00
IUUC-Mpu-065927 Mustela putorius furo 34.28 1.00e-41 162.00
IUUC-Mlu-067079 Myotis lucifugus 34.38 3.00e-47 181.00
IUUC-Nle-070180 Nomascus leucogenys 34.67 2.00e-41 162.00
IUUC-Opr-070847 Ochotona princeps 33.98 5.00e-35 140.00
IUUC-Ont-071846 Oreochromis niloticus 30.84 2.00e-34 139.00
IUUC-Oan-072783 Ornithorhynchus anatinus 36.45 3.00e-35 140.00
IUUC-Ocu-074527 Oryctolagus cuniculus 34.53 6.00e-42 164.00
IUUC-Oba-075256 Oryza barthii 54.85 4.00e-84 303.00
IUUC-Obr-076302 Oryza brachyantha 52.03 3.00e-88 317.00
IUUC-Ogl-077097 Oryza glaberrima 53.66 1.00e-94 338.00
IUUC-Ogu-078570 Oryza glumaepatula 56.48 5.00e-92 330.00
IUUC-Oin-079244 Oryza indica 54.09 2.00e-94 338.00
IUUC-Olo-080484 Oryza longistaminata 54.15 1.00e-63 235.00
IUUC-Ome-081814 Oryza meridionalis 53.66 2.00e-94 338.00
IUUC-Oni-082057 Oryza nivara 56.97 2.00e-91 328.00
IUUC-Opu-084176 Oryza punctata 53.22 2.00e-89 322.00
IUUC-Oru-084618 Oryza rufipogon 56.72 1.00e-91 328.00
IUUC-Osa-085602 Oryza sativa 56.07 8.00e-92 329.00
IUUC-Ola-086707 Oryzias latipes 33.64 2.00e-29 121.00
IUUC-Olu-087811 Ostreococcus lucimarinus 37.13 3.00e-60 224.00
IUUC-Oga-088560 Otolemur garnettii 33.33 2.00e-28 119.00
IUUC-Oar-090348 Ovis aries 34.04 6.00e-43 167.00
IUUC-Ptr-091060 Pan troglodytes 34.67 2.00e-41 162.00
IUUC-Pan-091855 Papio anubis 34.31 7.00e-39 153.00
IUUC-Psi-093505 Pelodiscus sinensis 34.75 3.00e-39 154.00
IUUC-Pma-094612 Petromyzon marinus 34.06 4.00e-33 134.00
IUUC-Ppa-095431 Physcomitrella patens 43.92 6.00e-90 323.00
IUUC-Pfo-097396 Poecilia formosa 31.13 5.00e-41 160.00
IUUC-Pab-098591 Pongo abelii 34.67 2.00e-41 162.00
IUUC-Pop-099661 Populus trichocarpa 50.47 5.00e-90 323.00
IUUC-Pca-101029 Procavia capensis 35.56 2.00e-38 152.00
IUUC-Ppe-101495 Prunus persica 61.80 6.00e-137 479.00
IUUC-Pva-102244 Pteropus vampyrus 33.41 4.00e-38 151.00
IUUC-Rno-105861 Rattus norvegicus 34.20 6.00e-38 150.00
IUUC-Sha-107045 Sarcophilus harrisii 34.84 1.00e-41 162.00
IUUC-Spo-108058 Schizosaccharomyces pombe 39.39 2.90e+00 25.80
IUUC-Smo-109325 Selaginella moellendorffii 46.50 7.00e-68 249.00
IUUC-Sit-110624 Setaria italica 52.53 1.00e-87 315.00
IUUC-Sly-110865 Solanum lycopersicum 98.57 5.00e-36 141.00
IUUC-Sar-113169 Sorex araneus 37.66 7.00e-36 143.00
IUUC-Sbi-114305 Sorghum bicolor 53.33 1.00e-89 322.00
IUUC-Ssc-115766 Sus scrofa 33.89 1.00e-40 159.00
IUUC-Tgu-117280 Taeniopygia guttata 33.33 3.00e-34 138.00
IUUC-Tru-117732 Takifugu rubripes 30.83 4.00e-36 144.00
IUUC-Tsy-119624 Tarsius syrichta 33.82 8.00e-37 146.00
IUUC-Tni-119852 Tetraodon nigroviridis 31.43 4.00e-37 147.00
IUUC-Tca-121865 Theobroma cacao 64.57 1.00e-123 435.00
IUUC-Tae-125925 Triticum aestivum 56.19 6.00e-97 346.00
IUUC-Tur-126237 Triticum urartu 55.10 3.00e-83 300.00
IUUC-Tbe-128148 Tupaia belangeri 31.60 6.00e-28 117.00
IUUC-Ttr-128793 Tursiops truncatus 33.41 1.00e-37 149.00
IUUC-Vpa-130625 Vicugna pacos 34.97 1.00e-29 123.00
IUUC-Vvi-131312 Vitis vinifera 62.94 6.00e-118 416.00
IUUC-Xtr-132756 Xenopus tropicalis 33.98 1.00e-39 155.00
IUUC-Xma-133377 Xiphophorus maculatus 31.29 5.00e-41 160.00
Created Date 25-Jun-2017

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