iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059935

UUCD1 version

UUC-MeG-00616

Ensembl Protein ID

ENSMGAP00000014304.2

UniProt Accession

G1NLC1; G1NLC1_MELGA

Protein Name

Uncharacterized protein

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000013533.2	ENSMGAT00000015233.2	ENSMGAP00000014304.2
ENSMGAG00000013533.2	ENSMGAT00000020913.1	ENSMGAP00000018633.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-118	393.6	577	906

Active Site

Position(s)	Description	Evidence
877	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al +++l+++ 
   Q: 577  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSSEIVNPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALNHRQLVNIY 662
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG++i Vt+eNk eYv+lv+e+
   Q: 663  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGASILVTQENKAEYVQLVTEL 748
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++ +++iqwFw+v+ee+++eer  +LqFvT
   Q: 749  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWLKNTEYTSGYERGDQVIQWFWDVVEELTQEERVLLLQFVT 837
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa ++     + f+i     + + lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 838  GSSRVPHGGFAHIMggsgLQNFTIAAvPYTANLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 906
           ******************888999995667799******************************986555 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

INNAWVMIFH LFYKMHRART VELPDDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTAACAATG CATGGGTTAT GATTTTCCAC CTTTTTTACA AGATGCATGT TAGTTCACTG 60
CATTTTCATG TAACACACAT TTTCTTTGCT TGTCGAAATA ACATTAAGTA GCACCTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	40.36	2.00e-82	302.00
IUUC-Aml-001490	Ailuropoda melanoleuca	93.36	0.00e+00	1744.00
IUUC-Atr-002582	Amborella trichopoda	42.95	3.00e-97	351.00
IUUC-Apl-003400	Anas platyrhynchos	94.33	0.00e+00	1245.00
IUUC-Aca-005375	Anolis carolinensis	91.89	0.00e+00	1743.00
IUUC-Aly-006157	Arabidopsis lyrata	44.55	8.00e-101	363.00
IUUC-Ath-007160	Arabidopsis thaliana	42.53	6.00e-94	340.00
IUUC-Acl-008254	Aspergillus clavatus	41.88	1.00e-94	342.00
IUUC-Afl-008712	Aspergillus flavus	42.11	7.00e-96	345.00
IUUC-Afu-009022	Aspergillus fumigatus	42.66	2.00e-95	345.00
IUUC-Ani-009412	Aspergillus nidulans	42.79	2.00e-97	352.00
IUUC-Ang-009771	Aspergillus niger	41.42	4.00e-92	334.00
IUUC-Aor-010186	Aspergillus oryzae	41.87	4.00e-88	319.00
IUUC-Ate-010253	Aspergillus terreus	42.79	6.00e-96	347.00
IUUC-Ame-011847	Astyanax mexicanus	84.29	0.00e+00	1633.00
IUUC-Bta-012831	Bos taurus	94.58	0.00e+00	1745.00
IUUC-Bdi-014884	Brachypodium distachyon	42.76	9.00e-97	350.00
IUUC-Bol-016533	Brassica oleracea	53.28	2.00e-79	288.00
IUUC-Bra-016726	Brassica rapa	44.77	2.00e-101	365.00
IUUC-Cja-019160	Callithrix jacchus	94.23	0.00e+00	1761.00
IUUC-Cfa-020346	Canis familiaris	93.78	0.00e+00	1758.00
IUUC-Cpo-021766	Cavia porcellus	93.22	0.00e+00	1753.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	42.89	2.00e-97	348.00
IUUC-Csa-023768	Chlorocebus sabaeus	93.89	0.00e+00	1760.00
IUUC-Cho-024688	Choloepus hoffmanni	89.87	0.00e+00	1120.00
IUUC-Cin-025417	Ciona intestinalis	51.50	2.00e-140	493.00
IUUC-Csv-025993	Ciona savignyi	43.49	0.00e+00	756.00
IUUC-Cme-027267	Cyanidioschyzon merolae	41.76	7.00e-85	309.00
IUUC-Dre-027819	Danio rerio	84.63	0.00e+00	1619.00
IUUC-Dno-029027	Dasypus novemcinctus	93.81	0.00e+00	1761.00
IUUC-Dor-030327	Dipodomys ordii	87.10	0.00e+00	1563.00
IUUC-Dse-031197	Dothistroma septosporum	40.13	4.00e-94	341.00
IUUC-Ete-032966	Echinops telfairi	86.78	0.00e+00	1617.00
IUUC-Eca-034339	Equus caballus	93.89	0.00e+00	1759.00
IUUC-Eeu-034544	Erinaceus europaeus	64.52	1.00e-175	610.00
IUUC-Fca-035617	Felis catus	92.91	0.00e+00	1252.00
IUUC-Fal-036687	Ficedula albicollis	94.53	0.00e+00	1809.00
IUUC-Fso-038464	Fusarium solani	40.93	5.00e-94	340.00
IUUC-Gmo-039508	Gadus morhua	87.93	0.00e+00	832.00
IUUC-Ggr-039946	Gaeumannomyces graminis	41.91	8.00e-95	343.00
IUUC-Gga-040845	Gallus gallus	95.71	0.00e+00	1853.00
IUUC-Gac-041894	Gasterosteus aculeatus	85.24	0.00e+00	1593.00
IUUC-Gma-044216	Glycine max	43.86	2.00e-99	358.00
IUUC-Ggo-044465	Gorilla gorilla	90.37	0.00e+00	1684.00
IUUC-Hsa-045731	Homo sapiens	94.11	0.00e+00	1763.00
IUUC-Hvu-047697	Hordeum vulgare	42.53	7.00e-96	347.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	94.22	0.00e+00	1763.00
IUUC-Lch-050436	Latimeria chalumnae	89.61	0.00e+00	1688.00
IUUC-Lpe-051550	Leersia perrieri	42.99	6.00e-98	353.00
IUUC-Loc-052287	Lepisosteus oculatus	85.01	0.00e+00	1656.00
IUUC-Lma-053159	Leptosphaeria maculans	39.91	5.00e-93	337.00
IUUC-Laf-053846	Loxodonta africana	94.33	0.00e+00	1770.00
IUUC-Mcc-055845	Macaca mulatta	94.00	0.00e+00	1763.00
IUUC-Meu-056060	Macropus eugenii	97.69	0.00e+00	706.00
IUUC-Mpo-057597	Magnaporthe poae	41.69	4.00e-94	341.00
IUUC-Mtr-057633	Medicago truncatula	42.34	1.00e-100	362.00
IUUC-Mmr-060960	Microcebus murinus	94.22	0.00e+00	1766.00
IUUC-Mdo-061851	Monodelphis domestica	91.20	0.00e+00	1765.00
IUUC-Mmu-063657	Mus musculus	92.89	0.00e+00	1746.00
IUUC-Mac-065229	Musa acuminata	42.95	3.00e-97	351.00
IUUC-Mpu-066161	Mustela putorius furo	96.23	0.00e+00	808.00
IUUC-Mlu-067354	Myotis lucifugus	91.99	0.00e+00	1702.00
IUUC-Nfi-068278	Neosartorya fischeri	42.66	1.00e-95	346.00
IUUC-Nle-069112	Nomascus leucogenys	94.00	0.00e+00	1760.00
IUUC-Opr-070686	Ochotona princeps	86.79	0.00e+00	793.00
IUUC-Ont-072398	Oreochromis niloticus	85.71	0.00e+00	1606.00
IUUC-Oan-073194	Ornithorhynchus anatinus	93.49	0.00e+00	1711.00
IUUC-Ocu-074397	Oryctolagus cuniculus	83.08	0.00e+00	1514.00
IUUC-Oba-075757	Oryza barthii	42.76	3.00e-97	351.00
IUUC-Obr-076553	Oryza brachyantha	43.21	6.00e-98	353.00
IUUC-Ogl-077520	Oryza glaberrima	42.76	5.00e-97	350.00
IUUC-Ogu-078278	Oryza glumaepatula	42.76	5.00e-97	350.00
IUUC-Oin-079767	Oryza indica	42.76	4.00e-97	351.00
IUUC-Olo-080380	Oryza longistaminata	42.60	1.00e-95	345.00
IUUC-Ome-081925	Oryza meridionalis	42.60	8.00e-96	346.00
IUUC-Oni-082619	Oryza nivara	42.76	5.00e-97	350.00
IUUC-Opu-083684	Oryza punctata	42.60	1.00e-95	346.00
IUUC-Oru-084501	Oryza rufipogon	42.76	4.00e-97	351.00
IUUC-Osa-086251	Oryza sativa	42.60	4.00e-97	348.00
IUUC-Ola-086777	Oryzias latipes	80.23	0.00e+00	1551.00
IUUC-Olu-087813	Ostreococcus lucimarinus	40.29	2.00e-86	312.00
IUUC-Oga-088684	Otolemur garnettii	94.01	0.00e+00	1759.00
IUUC-Oar-089428	Ovis aries	93.35	0.00e+00	1724.00
IUUC-Ptr-090529	Pan troglodytes	94.00	0.00e+00	1762.00
IUUC-Pan-091702	Papio anubis	93.89	0.00e+00	1760.00
IUUC-Psi-093969	Pelodiscus sinensis	93.06	0.00e+00	1759.00
IUUC-Pno-094871	Phaeosphaeria nodorum	39.91	1.00e-92	336.00
IUUC-Ppa-095834	Physcomitrella patens	43.18	5.00e-97	350.00
IUUC-Pfo-097364	Poecilia formosa	86.38	0.00e+00	1614.00
IUUC-Pab-098574	Pongo abelii	94.11	0.00e+00	1763.00
IUUC-Pop-099468	Populus trichocarpa	43.86	3.00e-99	358.00
IUUC-Pca-100525	Procavia capensis	83.62	5.00e-168	584.00
IUUC-Ppe-101641	Prunus persica	43.86	9.00e-100	360.00
IUUC-Pva-102365	Pteropus vampyrus	82.22	0.00e+00	1486.00
IUUC-Pgr-103465	Puccinia graminis	40.66	3.00e-100	362.00
IUUC-Ptt-103813	Puccinia triticina	38.12	6.00e-90	327.00
IUUC-Pte-104018	Pyrenophora teres	39.91	2.00e-91	332.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	40.13	8.00e-94	340.00
IUUC-Rno-105153	Rattus norvegicus	93.22	0.00e+00	1752.00
IUUC-Sha-107319	Sarcophilus harrisii	91.42	0.00e+00	1768.00
IUUC-Smo-109640	Selaginella moellendorffii	42.82	1.00e-97	352.00
IUUC-Sit-110598	Setaria italica	43.44	2.00e-97	352.00
IUUC-Sly-111706	Solanum lycopersicum	44.77	9.00e-102	366.00
IUUC-Stu-112894	Solanum tuberosum	33.90	5.00e-53	202.00
IUUC-Sar-113449	Sorex araneus	75.82	1.00e-161	563.00
IUUC-Sbi-114042	Sorghum bicolor	43.74	6.00e-98	353.00
IUUC-Sre-114958	Sporisorium reilianum	45.66	6.00e-110	390.00
IUUC-Ssc-115865	Sus scrofa	93.89	0.00e+00	1761.00
IUUC-Tgu-117225	Taeniopygia guttata	94.42	0.00e+00	1833.00
IUUC-Tru-118026	Takifugu rubripes	82.70	0.00e+00	1570.00
IUUC-Tsy-119407	Tarsius syrichta	81.11	0.00e+00	1462.00
IUUC-Tni-120234	Tetraodon nigroviridis	84.15	0.00e+00	1261.00
IUUC-Tca-121479	Theobroma cacao	43.64	2.00e-100	361.00
IUUC-Tae-125214	Triticum aestivum	42.04	2.00e-95	345.00
IUUC-Tur-126774	Triticum urartu	29.66	1.00e-46	180.00
IUUC-Tbe-127708	Tupaia belangeri	84.16	0.00e+00	826.00
IUUC-Ttr-128667	Tursiops truncatus	93.56	0.00e+00	1756.00
IUUC-Uma-129355	Ustilago maydis	46.33	2.00e-110	392.00
IUUC-Vpa-130200	Vicugna pacos	94.23	0.00e+00	1727.00
IUUC-Vvi-131078	Vitis vinifera	43.41	3.00e-99	357.00
IUUC-Xtr-132176	Xenopus tropicalis	88.01	0.00e+00	1703.00
IUUC-Xma-133936	Xiphophorus maculatus	82.31	0.00e+00	946.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence