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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063152
UUCD1 version UUC-MuM-00659
Ensembl Protein ID ENSMUSP00000023509.3
UniProt Accession Q8BRG6; Q3TQG0; Q78J30; Q8BQU1; Q9D5K3; KLH24_MOUSE
Genbank Protein ID BAB29759.2; BAC32131.1; BAC32732.1; BAE37423.1; AAH21407.2
Protein Name Kelch-like protein 24; Kainate receptor-interacting protein for GluR6
Genbank Nucleotide ID AK015239; AK044892; AK046446; AK163616; BC021407
Gene Name Klhl24
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000062901.2 ENSMUST00000023509.3 ENSMUSP00000023509.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.20e-21 76.6 66 131
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 6.90e-07 28.6 167 195
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dvi++v+g+ef++h++vL+a+Ss+F+a+f ++ +es+ +  vei+++ +e+++ +l+++Ytgk+++
   Q: 66   TDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESR-EMLVEINGILAEAMECFLQYVYTGKVKI 131
           7************************************9.999**********************986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 3    NclgilrfAdlydcpdLkdaaldfilkhF 31
           Nclgi rfAd++++  L  ++ +f+l+ F
   Q: 167  NCLGIQRFADTHSLKTLFTKCKTFALQTF 195
           *************************9977 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
 Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
Protein Sequence
(Fasta)
MVLILGRRLN REDLGVRDSP ATKRKVFEMD PKSLTGHEYF DFSSGSSHAE NILQIFNEFR 60
DSRLFTDVII CVEGKEFPCH RAVLSACSSY FRAMFCNDHR ESREMLVEIN GILAEAMECF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063152|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACGGTCACA TGTTTCCTTT GTTGTGAGCA GTGGCAGAGA CTGGCGGTGG CTCGAGGAGA 60
CGCCGGCGCA GCAGGGACGG GGGTCGCCGC TCGTGCCGCT TCCAGCCTGC GCCGAGAGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063152|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030596--KLHL24
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0030424--C:axon
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0043204--C:perikaryon
GO:0016567--P:protein ubiquitination
GO:2000312--P:regulation of kainate selective glutamate receptor activity
KEGG mmu:75785
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001447 Ailuropoda melanoleuca 98.84 0.00e+00 1208.00
IUUC-Aca-004821 Anolis carolinensis 94.33 0.00e+00 1161.00
IUUC-Ame-010778 Astyanax mexicanus 84.64 0.00e+00 1093.00
IUUC-Bta-012622 Bos taurus 98.67 0.00e+00 1204.00
IUUC-Cja-018938 Callithrix jacchus 99.50 0.00e+00 1217.00
IUUC-Cfa-020831 Canis familiaris 99.17 0.00e+00 1214.00
IUUC-Cpo-021569 Cavia porcellus 98.50 0.00e+00 1205.00
IUUC-Csa-024070 Chlorocebus sabaeus 99.33 0.00e+00 1216.00
IUUC-Cin-025465 Ciona intestinalis 53.20 0.00e+00 647.00
IUUC-Csv-025878 Ciona savignyi 53.83 0.00e+00 635.00
IUUC-Dre-028103 Danio rerio 84.95 0.00e+00 1089.00
IUUC-Dno-029374 Dasypus novemcinctus 98.17 0.00e+00 1199.00
IUUC-Dor-030922 Dipodomys ordii 86.01 2.00e-143 502.00
IUUC-Dse-031370 Dothistroma septosporum 36.36 1.00e-05 43.50
IUUC-Ete-032909 Echinops telfairi 97.67 0.00e+00 1184.00
IUUC-Eca-034390 Equus caballus 98.83 0.00e+00 1209.00
IUUC-Fca-036449 Felis catus 99.00 0.00e+00 1210.00
IUUC-Fal-036612 Ficedula albicollis 96.17 0.00e+00 1181.00
IUUC-Gmo-038760 Gadus morhua 81.30 0.00e+00 1036.00
IUUC-Gga-040779 Gallus gallus 96.21 0.00e+00 741.00
IUUC-Gac-042145 Gasterosteus aculeatus 82.38 0.00e+00 1059.00
IUUC-Ggo-045506 Gorilla gorilla 99.17 0.00e+00 1212.00
IUUC-Hsa-046510 Homo sapiens 99.33 0.00e+00 1216.00
IUUC-Itr-048255 Ictidomys tridecemlineatus 99.00 0.00e+00 1210.00
IUUC-Lch-049594 Latimeria chalumnae 86.91 0.00e+00 1100.00
IUUC-Loc-052147 Lepisosteus oculatus 86.45 0.00e+00 1091.00
IUUC-Laf-054224 Loxodonta africana 98.34 0.00e+00 1200.00
IUUC-Meu-056366 Macropus eugenii 96.74 5.00e-158 551.00
IUUC-Mga-059535 Meleagris gallopavo 96.00 0.00e+00 1164.00
IUUC-Mdo-063082 Monodelphis domestica 96.50 0.00e+00 1182.00
IUUC-Mpu-065928 Mustela putorius furo 99.17 0.00e+00 1214.00
IUUC-Mlu-068041 Myotis lucifugus 98.50 0.00e+00 1204.00
IUUC-Nle-069293 Nomascus leucogenys 99.33 0.00e+00 1216.00
IUUC-Opr-070368 Ochotona princeps 99.17 0.00e+00 1214.00
IUUC-Ont-071571 Oreochromis niloticus 82.14 0.00e+00 1035.00
IUUC-Oan-072849 Ornithorhynchus anatinus 96.83 0.00e+00 1188.00
IUUC-Ocu-073987 Oryctolagus cuniculus 99.00 0.00e+00 1210.00
IUUC-Ola-087513 Oryzias latipes 81.64 0.00e+00 1055.00
IUUC-Oga-088595 Otolemur garnettii 99.17 0.00e+00 1212.00
IUUC-Oar-089935 Ovis aries 98.67 0.00e+00 1204.00
IUUC-Ptr-091664 Pan troglodytes 99.00 0.00e+00 1206.00
IUUC-Pan-091881 Papio anubis 99.00 0.00e+00 1210.00
IUUC-Psi-092983 Pelodiscus sinensis 96.00 0.00e+00 1179.00
IUUC-Pfo-096218 Poecilia formosa 76.85 0.00e+00 982.00
IUUC-Pab-098487 Pongo abelii 99.33 0.00e+00 1216.00
IUUC-Pca-100916 Procavia capensis 97.67 0.00e+00 1193.00
IUUC-Pva-103010 Pteropus vampyrus 99.17 0.00e+00 1212.00
IUUC-Rno-105025 Rattus norvegicus 99.67 0.00e+00 1210.00
IUUC-Sha-106793 Sarcophilus harrisii 97.17 0.00e+00 1188.00
IUUC-Sar-113290 Sorex araneus 99.26 0.00e+00 844.00
IUUC-Ssc-115631 Sus scrofa 98.67 0.00e+00 1205.00
IUUC-Tgu-116856 Taeniopygia guttata 96.33 0.00e+00 1183.00
IUUC-Tru-118210 Takifugu rubripes 82.33 0.00e+00 1031.00
IUUC-Tsy-118964 Tarsius syrichta 99.67 0.00e+00 633.00
IUUC-Tni-120462 Tetraodon nigroviridis 82.38 0.00e+00 1026.00
IUUC-Tbe-128114 Tupaia belangeri 98.04 7.00e-177 613.00
IUUC-Ttr-128565 Tursiops truncatus 99.17 0.00e+00 1209.00
IUUC-Vpa-130093 Vicugna pacos 88.83 0.00e+00 1066.00
IUUC-Xtr-132233 Xenopus tropicalis 90.50 0.00e+00 1127.00
Created Date 25-Jun-2017

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