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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063369
UUCD1 version UUC-MuM-00518
Ensembl Protein ID ENSMUSP00000020258.8
UniProt Accession Q6PAV2; Q3UL34; Q3UPX2; Q810A0; Q811C9; Q8R315; Q9D797; HERC4_MOUSE
Genbank Protein ID BAB26286.1; BAE25272.1; BAE26617.1; BAE28095.1; AAH26855.1; AAH43082.1; AAH47157.1; AAH60033.1
Protein Name Probable E3 ubiquitin-protein ligase HERC4; HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4
Genbank Nucleotide ID AK009436; AK143111; AK145735; AK147723; BC026855; BC043082; BC047157; BC060033
Gene Name Herc4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000020064.8 ENSMUST00000020258.8 ENSMUSP00000020258.8
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.30e-99 334.1 725 1048
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 725  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 806
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k sl+dl+e++p + +s+++++++ e+diee+ ++l+f+++ e++g t+++eL+ +G+++ V+ +N++e+v+++
   Q: 807  HFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGATEVKELVLNGADTAVNRQNRQEFVDAY 892
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l lF+++el+ ++ G++++d+++l+k+t+ykg+y +d+p+i+ Fwev++e+  e++k+f
   Q: 893  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQF 979
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l+ kL+ Ai++++gF+l
   Q: 980  LLFLTGSDRIPILGMKSLK---LVIQStGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSL 1048
           *******************...7777758888**************************************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
 Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.
Protein Sequence
(Fasta)
MLCWGNASYG QLGLGGIDEE IVLEPRRSDF FVNKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVA CGEAHTLALN DKGQVYAWGL DSDGQLGLQG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063369|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CACCGCCCCT CTCCCTTGTC GCCTGGCTCT CCCTCGTCGC CAGCCTCTCC CTCAGCTCTC 60
TCCACCCCTC GTGGTCTCCG CCCTGCTCAC CGCCAGCCCT TCCCCTCCCG CTCCATCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063369|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030154--P:cell differentiation
GO:0016567--P:protein ubiquitination
GO:0007283--P:spermatogenesis
KEGG mmu:67345
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001666 Ailuropoda melanoleuca 96.12 0.00e+00 1969.00
IUUC-Apl-003295 Anas platyrhynchos 86.86 0.00e+00 1866.00
IUUC-Aca-004336 Anolis carolinensis 85.93 0.00e+00 1845.00
IUUC-Ame-010768 Astyanax mexicanus 73.43 0.00e+00 1601.00
IUUC-Bta-013279 Bos taurus 95.65 0.00e+00 1963.00
IUUC-Cel-018150 Caenorhabditis elegans 34.47 2.00e-155 543.00
IUUC-Cja-019023 Callithrix jacchus 95.84 0.00e+00 1963.00
IUUC-Cfa-021074 Canis familiaris 96.31 0.00e+00 1976.00
IUUC-Cpo-021461 Cavia porcellus 94.15 0.00e+00 1920.00
IUUC-Csa-024261 Chlorocebus sabaeus 96.31 0.00e+00 1974.00
IUUC-Cho-024513 Choloepus hoffmanni 77.74 0.00e+00 871.00
IUUC-Cin-025232 Ciona intestinalis 42.86 0.00e+00 834.00
IUUC-Dre-028829 Danio rerio 75.00 0.00e+00 1565.00
IUUC-Dno-029445 Dasypus novemcinctus 93.02 0.00e+00 1586.00
IUUC-Dor-030158 Dipodomys ordii 94.51 0.00e+00 855.00
IUUC-Dme-032103 Drosophila melanogaster 45.22 0.00e+00 899.00
IUUC-Ete-033072 Echinops telfairi 86.18 0.00e+00 1741.00
IUUC-Eca-033317 Equus caballus 94.13 0.00e+00 1928.00
IUUC-Fca-035682 Felis catus 97.24 0.00e+00 1986.00
IUUC-Fal-036969 Ficedula albicollis 85.53 0.00e+00 1839.00
IUUC-Gmo-038671 Gadus morhua 74.03 0.00e+00 1599.00
IUUC-Gga-041174 Gallus gallus 86.47 0.00e+00 1863.00
IUUC-Gac-042600 Gasterosteus aculeatus 73.68 0.00e+00 1537.00
IUUC-Ggo-044589 Gorilla gorilla 96.31 0.00e+00 2005.00
IUUC-Hsa-046772 Homo sapiens 96.22 0.00e+00 2000.00
IUUC-Lch-050147 Latimeria chalumnae 80.40 0.00e+00 1437.00
IUUC-Loc-052684 Lepisosteus oculatus 79.26 0.00e+00 1677.00
IUUC-Laf-053844 Loxodonta africana 95.27 0.00e+00 1952.00
IUUC-Mcc-055531 Macaca mulatta 94.08 0.00e+00 1960.00
IUUC-Mga-060151 Meleagris gallopavo 85.54 0.00e+00 1546.00
IUUC-Mmr-060954 Microcebus murinus 96.22 0.00e+00 1968.00
IUUC-Mdo-062246 Monodelphis domestica 92.40 0.00e+00 1778.00
IUUC-Mpu-065936 Mustela putorius furo 95.52 0.00e+00 1809.00
IUUC-Mlu-067326 Myotis lucifugus 94.99 0.00e+00 1915.00
IUUC-Nle-069453 Nomascus leucogenys 97.24 0.00e+00 1982.00
IUUC-Ont-071720 Oreochromis niloticus 75.00 0.00e+00 1576.00
IUUC-Oan-073464 Ornithorhynchus anatinus 91.65 0.00e+00 1770.00
IUUC-Ocu-074207 Oryctolagus cuniculus 94.07 0.00e+00 1814.00
IUUC-Ola-086762 Oryzias latipes 74.14 0.00e+00 1531.00
IUUC-Oga-088435 Otolemur garnettii 96.12 0.00e+00 1968.00
IUUC-Oar-089233 Ovis aries 95.84 0.00e+00 1965.00
IUUC-Ptr-091368 Pan troglodytes 96.40 0.00e+00 2003.00
IUUC-Pan-092300 Papio anubis 96.31 0.00e+00 1974.00
IUUC-Psi-093406 Pelodiscus sinensis 87.80 0.00e+00 1886.00
IUUC-Pma-094113 Petromyzon marinus 70.93 0.00e+00 1144.00
IUUC-Ppa-095354 Physcomitrella patens 33.24 2.00e-154 540.00
IUUC-Pfo-097021 Poecilia formosa 73.59 0.00e+00 1611.00
IUUC-Pab-098327 Pongo abelii 96.59 0.00e+00 2004.00
IUUC-Pca-101075 Procavia capensis 95.57 0.00e+00 816.00
IUUC-Pva-102909 Pteropus vampyrus 84.67 0.00e+00 1659.00
IUUC-Rno-105457 Rattus norvegicus 98.11 0.00e+00 2053.00
IUUC-Sha-106632 Sarcophilus harrisii 92.95 0.00e+00 1937.00
IUUC-Sar-113679 Sorex araneus 88.34 0.00e+00 1144.00
IUUC-Tgu-116849 Taeniopygia guttata 81.74 0.00e+00 1736.00
IUUC-Tru-118206 Takifugu rubripes 72.62 0.00e+00 1473.00
IUUC-Tsy-119521 Tarsius syrichta 82.31 0.00e+00 1581.00
IUUC-Tni-120233 Tetraodon nigroviridis 72.12 0.00e+00 1460.00
IUUC-Tbe-127941 Tupaia belangeri 80.98 0.00e+00 1371.00
IUUC-Ttr-128926 Tursiops truncatus 95.69 0.00e+00 1149.00
IUUC-Vpa-130448 Vicugna pacos 95.08 0.00e+00 1952.00
IUUC-Xtr-132719 Xenopus tropicalis 70.95 0.00e+00 1401.00
Created Date 25-Jun-2017

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