iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037547

Ensembl Protein ID

ENSFALP00000012611.1

UniProt Accession

U3KC57; U3KC57_FICAL

Genbank Protein ID

ENSFALP00000012611

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000577

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000012079.1	ENSFALT00000012661.1	ENSFALP00000012611.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-134	446.4	561	890

Active Site

Position(s)	Description	Evidence
860	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 561  FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 649
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d   ++ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv+++r
   Q: 650  IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DP--AELDLRFIVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLVIQWR 733
           *********************************99...44..558******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv d+k +tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 734  FVSRVQKQMTAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLHTKYKNGYNINHQVIQWFWKAVLMMDSEKRIRLLQFVTG 822
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 823  TSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYDSFEDLWDKLLLAIENTQGFD 890
           *******************************************************************8 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MYLLLRENTR IVRVKVIAAI GLAKKDILGA SDPYVKVTLY DPVNGVLTSI QTKTIRKSLN 60
PKWNEELLFR VNPQKHRLLF EVFDENRLTR DDFLGQVDIP LYQLPTENPS MERPYTFKDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTGTCAC AGGCGGTGCG ACAGGAGCGG TGCGTGGATT AGCGCGGTAC AAAAGGCAGC 60
GCGGTGCCTG AGCGATGGGC TCATCCCCGC GCTGCCCGTA GCGGGAGGCT GGAATTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	79.49	0.00e+00	1304.00
IUUC-Apl-003886	Anas platyrhynchos	86.85	0.00e+00	1530.00
IUUC-Afl-008713	Aspergillus flavus	47.96	4.00e-156	545.00
IUUC-Ani-009259	Aspergillus nidulans	48.31	1.00e-156	546.00
IUUC-Ang-009738	Aspergillus niger	47.47	7.00e-156	544.00
IUUC-Ame-011138	Astyanax mexicanus	84.34	0.00e+00	843.00
IUUC-Bgr-012148	Blumeria graminis	46.37	8.00e-152	530.00
IUUC-Bta-012453	Bos taurus	79.90	0.00e+00	1262.00
IUUC-Bci-013785	Botrytis cinerea	47.42	1.00e-154	540.00
IUUC-Cja-019034	Callithrix jacchus	81.61	0.00e+00	1210.00
IUUC-Cfa-020258	Canis familiaris	81.64	0.00e+00	1287.00
IUUC-Cpo-021648	Cavia porcellus	79.24	0.00e+00	1415.00
IUUC-Csa-023334	Chlorocebus sabaeus	82.21	0.00e+00	1439.00
IUUC-Cin-025157	Ciona intestinalis	55.56	0.00e+00	964.00
IUUC-Dre-027924	Danio rerio	67.74	0.00e+00	1004.00
IUUC-Dno-029159	Dasypus novemcinctus	78.47	0.00e+00	1150.00
IUUC-Dme-032166	Drosophila melanogaster	67.41	0.00e+00	711.00
IUUC-Ete-032409	Echinops telfairi	75.75	0.00e+00	1042.00
IUUC-Eca-033441	Equus caballus	81.53	0.00e+00	1401.00
IUUC-Eeu-034546	Erinaceus europaeus	70.57	0.00e+00	1031.00
IUUC-Fca-036384	Felis catus	81.09	0.00e+00	1315.00
IUUC-Gmo-039679	Gadus morhua	69.25	0.00e+00	1196.00
IUUC-Gga-040524	Gallus gallus	93.80	0.00e+00	1583.00
IUUC-Gac-042607	Gasterosteus aculeatus	67.06	0.00e+00	1199.00
IUUC-Hsa-046479	Homo sapiens	81.39	0.00e+00	1305.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	72.19	0.00e+00	1058.00
IUUC-Lch-050445	Latimeria chalumnae	73.21	0.00e+00	1171.00
IUUC-Loc-052645	Lepisosteus oculatus	73.55	0.00e+00	1319.00
IUUC-Mcc-055585	Macaca mulatta	82.13	0.00e+00	1307.00
IUUC-Meu-056897	Macropus eugenii	93.03	1.00e-166	580.00
IUUC-Mga-059362	Meleagris gallopavo	86.60	0.00e+00	1556.00
IUUC-Mmr-061061	Microcebus murinus	81.76	0.00e+00	1345.00
IUUC-Mmu-063318	Mus musculus	72.47	0.00e+00	1269.00
IUUC-Mpu-066567	Mustela putorius furo	81.57	0.00e+00	1452.00
IUUC-Mlu-068148	Myotis lucifugus	81.64	0.00e+00	1308.00
IUUC-Ncr-068918	Neurospora crassa	46.99	2.00e-154	539.00
IUUC-Nle-069225	Nomascus leucogenys	81.27	0.00e+00	1310.00
IUUC-Ont-071664	Oreochromis niloticus	67.87	0.00e+00	1187.00
IUUC-Oan-073019	Ornithorhynchus anatinus	83.86	0.00e+00	1400.00
IUUC-Ocu-074409	Oryctolagus cuniculus	81.27	0.00e+00	1303.00
IUUC-Oga-088241	Otolemur garnettii	74.50	0.00e+00	1157.00
IUUC-Oar-089797	Ovis aries	80.75	0.00e+00	1374.00
IUUC-Ptr-091629	Pan troglodytes	81.47	0.00e+00	1197.00
IUUC-Psi-093618	Pelodiscus sinensis	89.32	0.00e+00	1382.00
IUUC-Pno-095118	Phaeosphaeria nodorum	46.98	2.00e-161	563.00
IUUC-Pfo-097145	Poecilia formosa	69.55	0.00e+00	1192.00
IUUC-Pab-098394	Pongo abelii	81.76	0.00e+00	1433.00
IUUC-Pca-100568	Procavia capensis	72.17	0.00e+00	1047.00
IUUC-Ptt-103806	Puccinia triticina	52.54	1.00e-118	420.00
IUUC-Pte-104016	Pyrenophora teres	49.83	3.00e-160	558.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.83	3.00e-160	558.00
IUUC-Rno-106095	Rattus norvegicus	72.36	0.00e+00	1256.00
IUUC-Sha-107370	Sarcophilus harrisii	76.65	0.00e+00	1246.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.09	5.00e-153	534.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.68	3.00e-155	542.00
IUUC-Tgu-117474	Taeniopygia guttata	97.52	0.00e+00	1665.00
IUUC-Tru-117675	Takifugu rubripes	67.06	0.00e+00	1187.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.22	0.00e+00	1160.00
IUUC-Tvi-122595	Trichoderma virens	45.96	4.00e-151	528.00
IUUC-Tbe-127408	Tupaia belangeri	75.34	0.00e+00	1012.00
IUUC-Ttr-128437	Tursiops truncatus	73.75	0.00e+00	1009.00
IUUC-Vpa-130503	Vicugna pacos	77.10	0.00e+00	1125.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence