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Tag Content
UUCD2 ID IUUC-Ptr-091629
UUCD1 version UUC-PaT-00271
Ensembl Protein ID ENSPTRP00000012140.4
UniProt Accession H2Q9H4; H2Q9H4_PANTR
Genbank Protein ID ENSPTRP00000012140
Protein Name Uncharacterized protein
Genbank Nucleotide ID AACZ03098663
Gene Name NEDD4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPTRG00000007102.5 ENSPTRT00000013107.4 ENSPTRP00000012140.4
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 2.20e-135 451.4 915 1244
Active Site
Position(s) Description Evidence
1214 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 915  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1001
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1002 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLV 1083
           ***********************************99...6666..7**************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++
   Q: 1084 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRL 1170
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1171 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1244
           *************************************************************************8 PP
   
Organism Pan troglodytes
Protein Sequence
(Fasta)
MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSD DASFTCILKD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Ptr-091629|E3,HECT|Pan troglodytes
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA CCCTTTGTCA 60
GAAACCTCCG GAGATGACTT GGATAGCCAT GTTCACATGT GCTTCAAAAG ACCAACACGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ptr-091629|E3,HECT|Pan troglodytes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0044111--P:development involved in symbiotic interaction
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0031175--P:neuron projection development
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001201 Ailuropoda melanoleuca 94.44 0.00e+00 1415.00
IUUC-Ath-007472 Arabidopsis thaliana 44.90 8.00e-92 333.00
IUUC-Ame-011138 Astyanax mexicanus 83.75 0.00e+00 853.00
IUUC-Bta-012453 Bos taurus 90.32 0.00e+00 1331.00
IUUC-Cja-019034 Callithrix jacchus 95.51 0.00e+00 2315.00
IUUC-Cfa-020258 Canis familiaris 95.21 0.00e+00 1370.00
IUUC-Cpo-021648 Cavia porcellus 88.77 0.00e+00 1338.00
IUUC-Csa-023334 Chlorocebus sabaeus 97.06 0.00e+00 1382.00
IUUC-Cho-024672 Choloepus hoffmanni 83.53 0.00e+00 721.00
IUUC-Cin-025157 Ciona intestinalis 57.41 0.00e+00 838.00
IUUC-Dno-029159 Dasypus novemcinctus 88.58 0.00e+00 2058.00
IUUC-Dor-030729 Dipodomys ordii 80.15 0.00e+00 1047.00
IUUC-Dme-032166 Drosophila melanogaster 67.99 0.00e+00 714.00
IUUC-Ete-032409 Echinops telfairi 85.54 0.00e+00 1196.00
IUUC-Eca-033441 Equus caballus 95.49 0.00e+00 1336.00
IUUC-Eeu-034546 Erinaceus europaeus 73.46 0.00e+00 1387.00
IUUC-Fca-036384 Felis catus 94.68 0.00e+00 1413.00
IUUC-Fal-037547 Ficedula albicollis 80.93 0.00e+00 1199.00
IUUC-Gmo-039679 Gadus morhua 66.53 0.00e+00 979.00
IUUC-Gga-040524 Gallus gallus 82.02 0.00e+00 1206.00
IUUC-Ggo-045462 Gorilla gorilla 98.60 0.00e+00 1037.00
IUUC-Hsa-046479 Homo sapiens 97.86 0.00e+00 1437.00
IUUC-Itr-048383 Ictidomys tridecemlineatus 83.17 0.00e+00 1207.00
IUUC-Lch-050445 Latimeria chalumnae 72.37 0.00e+00 1098.00
IUUC-Laf-053638 Loxodonta africana 82.97 0.00e+00 1246.00
IUUC-Mcc-055585 Macaca mulatta 97.33 0.00e+00 1395.00
IUUC-Meu-056897 Macropus eugenii 95.47 2.00e-171 596.00
IUUC-Mga-059362 Meleagris gallopavo 74.47 0.00e+00 1173.00
IUUC-Mvi-060395 Microbotryum violaceum 53.31 5.00e-150 525.00
IUUC-Mmr-061061 Microcebus murinus 94.81 0.00e+00 1438.00
IUUC-Mdo-062178 Monodelphis domestica 55.12 0.00e+00 1364.00
IUUC-Mmu-063318 Mus musculus 77.60 0.00e+00 1150.00
IUUC-Mac-065557 Musa acuminata 44.92 6.00e-89 324.00
IUUC-Mpu-066567 Mustela putorius furo 93.94 0.00e+00 1400.00
IUUC-Mlu-068148 Myotis lucifugus 94.13 0.00e+00 1388.00
IUUC-Nle-069225 Nomascus leucogenys 97.59 0.00e+00 1451.00
IUUC-Opr-070443 Ochotona princeps 77.12 0.00e+00 969.00
IUUC-Oan-073019 Ornithorhynchus anatinus 85.54 0.00e+00 1282.00
IUUC-Ocu-074409 Oryctolagus cuniculus 91.46 0.00e+00 1377.00
IUUC-Olo-080326 Oryza longistaminata 43.80 4.00e-90 328.00
IUUC-Oga-088241 Otolemur garnettii 86.51 0.00e+00 1238.00
IUUC-Oar-089797 Ovis aries 93.94 0.00e+00 1378.00
IUUC-Psi-093618 Pelodiscus sinensis 83.57 0.00e+00 1213.00
IUUC-Pab-098394 Pongo abelii 97.46 0.00e+00 1402.00
IUUC-Pop-099613 Populus trichocarpa 44.64 5.00e-93 337.00
IUUC-Pca-100568 Procavia capensis 72.33 0.00e+00 1467.00
IUUC-Pva-102303 Pteropus vampyrus 86.04 0.00e+00 1860.00
IUUC-Rno-106095 Rattus norvegicus 77.73 0.00e+00 1154.00
IUUC-Sha-107370 Sarcophilus harrisii 78.13 0.00e+00 1224.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 50.63 6.00e-157 547.00
IUUC-Sit-110149 Setaria italica 45.04 2.00e-95 345.00
IUUC-Sbi-113794 Sorghum bicolor 44.50 3.00e-94 342.00
IUUC-Tgu-117474 Taeniopygia guttata 81.20 0.00e+00 1207.00
IUUC-Tru-117675 Takifugu rubripes 65.10 0.00e+00 972.00
IUUC-Tsy-118806 Tarsius syrichta 89.07 0.00e+00 1093.00
IUUC-Tbe-127408 Tupaia belangeri 81.32 0.00e+00 1924.00
IUUC-Ttr-128437 Tursiops truncatus 85.05 0.00e+00 1963.00
IUUC-Vpa-130503 Vicugna pacos 87.74 0.00e+00 2117.00
Created Date 25-Jun-2017

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