iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117675

UUCD1 version

UUC-TaR-00990

Ensembl Protein ID

ENSTRUP00000045893.1

UniProt Accession

H2V9K3; H2V9K3_TAKRU

Protein Name

Uncharacterized protein

Gene Name

nedd4a; nedd4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000017899.1	ENSTRUT00000046046.1	ENSTRUP00000045892.1
ENSTRUG00000017899.1	ENSTRUT00000046047.1	ENSTRUP00000045893.1
ENSTRUG00000017899.1	ENSTRUT00000046048.1	ENSTRUP00000045894.1
ENSTRUG00000017899.1	ENSTRUT00000046049.1	ENSTRUP00000045895.1
ENSTRUG00000017899.1	ENSTRUT00000046050.1	ENSTRUP00000045896.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-132	442.2	596	926

Active Site

Position(s)	Description	Evidence
896	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           + lk+rl+vef+gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl +F+f+Gr+ g+a+ +g+lld++
   Q: 596  DLLKARLWVEFEGEKGLDYGGVAREWFFLMSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLTYFKFIGRVAGMAVHHGKLLDAF 684
           56899************************************************************************************ PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           + ++fyk++l+k+++l+d+e+vd+e+++sl++i+en   d ++  ldl+f+v+ee++g+t+++eLk+gG +i Vtn+Nk+eY++lv+++
   Q: 685  FIRPFYKMMLQKPITLQDMESVDSEYFNSLMWILEN---DPTD--LDLMFTVDEELFGQTHQHELKSGGTDIIVTNDNKKEYIHLVIQW 768
           **********************************99...6666..7999999************************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+ ++i+ q++af+eGf e+ipl+l+++F+e+elell+cG  ++dv+d++++t+yk+gy +++ +iqwFw+++  ++ e r ++LqFvT
   Q: 769  RFVNRIQMQMTAFKEGFFELIPLDLIKIFDENELELLMCGLGDVDVNDWRENTRYKSGYASNHIVIQWFWKTVLLMDGERRIRLLQFVT 857
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g+sr+P++Gfael     p+lf+i+++++ d+lP+++TCfn+L+LP+Y+s e+l++kL +Aie+++gF+
   Q: 858  GTSRVPMNGFAELYgsngPQLFTIEQWGTRDKLPRAHTCFNRLDLPPYESFEELRDKLHIAIENAQGFD 926
           ********************************************************************8 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MASLSPPVRG LHTDEEESRI LKVKVVAGIG LAKKDILGAS DPYTKLSLYD PASGEITSLQ 60
TKTIKKTLDP KWNEEFFFRV DPRKHRLLFE VFDENRLTRD DFLGQVDVPL NQIPTENPDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGACGGG AGGAAGGAGG AAGGAGGAAG CGGAGCTGGA GGAGGAGGAA CAGGAACAGC 60
AGTGACGGCG GTGTCACAAC TGGCTCTTAT CTAATAACAT CCAGTGTAAA ATCACATGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	66.39	0.00e+00	1092.00
IUUC-Apl-003886	Anas platyrhynchos	64.43	0.00e+00	1172.00
IUUC-Ame-011138	Astyanax mexicanus	88.59	0.00e+00	876.00
IUUC-Bta-012453	Bos taurus	64.85	0.00e+00	1043.00
IUUC-Cel-018564	Caenorhabditis elegans	51.87	1.00e-177	616.00
IUUC-Cja-019034	Callithrix jacchus	66.14	0.00e+00	996.00
IUUC-Cfa-020258	Canis familiaris	65.51	0.00e+00	1061.00
IUUC-Cpo-021648	Cavia porcellus	64.30	0.00e+00	1196.00
IUUC-Csa-023334	Chlorocebus sabaeus	66.03	0.00e+00	1206.00
IUUC-Cin-025157	Ciona intestinalis	56.20	0.00e+00	989.00
IUUC-Csv-026098	Ciona savignyi	57.85	0.00e+00	652.00
IUUC-Dre-027924	Danio rerio	69.58	0.00e+00	1055.00
IUUC-Dno-029159	Dasypus novemcinctus	64.87	0.00e+00	933.00
IUUC-Dme-032166	Drosophila melanogaster	66.99	0.00e+00	735.00
IUUC-Ete-032409	Echinops telfairi	61.86	0.00e+00	867.00
IUUC-Eca-033441	Equus caballus	65.57	0.00e+00	1169.00
IUUC-Eeu-034546	Erinaceus europaeus	58.98	0.00e+00	874.00
IUUC-Fca-036384	Felis catus	66.59	0.00e+00	1083.00
IUUC-Fal-037547	Ficedula albicollis	67.32	0.00e+00	1201.00
IUUC-Gmo-039679	Gadus morhua	71.73	0.00e+00	1308.00
IUUC-Gga-040524	Gallus gallus	66.38	0.00e+00	1190.00
IUUC-Gac-042607	Gasterosteus aculeatus	74.31	0.00e+00	1370.00
IUUC-Hsa-046479	Homo sapiens	66.03	0.00e+00	1080.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	59.77	0.00e+00	874.00
IUUC-Lch-050445	Latimeria chalumnae	67.50	0.00e+00	1114.00
IUUC-Loc-052645	Lepisosteus oculatus	73.09	0.00e+00	1342.00
IUUC-Laf-053638	Loxodonta africana	63.83	0.00e+00	1021.00
IUUC-Mcc-055585	Macaca mulatta	65.55	0.00e+00	1070.00
IUUC-Meu-056897	Macropus eugenii	87.11	1.00e-156	546.00
IUUC-Mga-059362	Meleagris gallopavo	64.71	0.00e+00	1193.00
IUUC-Mmr-061061	Microcebus murinus	65.36	0.00e+00	1090.00
IUUC-Mdo-062178	Monodelphis domestica	58.31	0.00e+00	1012.00
IUUC-Mmu-063318	Mus musculus	61.25	0.00e+00	1092.00
IUUC-Mpu-066567	Mustela putorius furo	67.52	0.00e+00	1232.00
IUUC-Mlu-068148	Myotis lucifugus	65.49	0.00e+00	1065.00
IUUC-Nle-069225	Nomascus leucogenys	66.15	0.00e+00	1092.00
IUUC-Ont-071664	Oreochromis niloticus	76.29	0.00e+00	1360.00
IUUC-Oan-073019	Ornithorhynchus anatinus	67.83	0.00e+00	1170.00
IUUC-Ocu-074409	Oryctolagus cuniculus	65.32	0.00e+00	1082.00
IUUC-Oga-088241	Otolemur garnettii	60.10	0.00e+00	933.00
IUUC-Oar-089797	Ovis aries	66.06	0.00e+00	1131.00
IUUC-Ptr-091629	Pan troglodytes	66.94	0.00e+00	981.00
IUUC-Psi-093618	Pelodiscus sinensis	65.48	0.00e+00	1060.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.22	1.00e-154	540.00
IUUC-Ppa-095250	Physcomitrella patens	45.71	2.00e-84	305.00
IUUC-Pfo-097145	Poecilia formosa	73.43	0.00e+00	1312.00
IUUC-Pab-098394	Pongo abelii	65.53	0.00e+00	1194.00
IUUC-Pca-100568	Procavia capensis	60.54	0.00e+00	905.00
IUUC-Rno-106095	Rattus norvegicus	60.71	0.00e+00	1087.00
IUUC-Sha-107370	Sarcophilus harrisii	62.77	0.00e+00	1036.00
IUUC-Tgu-117474	Taeniopygia guttata	67.48	0.00e+00	1221.00
IUUC-Tni-119993	Tetraodon nigroviridis	81.61	0.00e+00	1483.00
IUUC-Tbe-127408	Tupaia belangeri	61.31	0.00e+00	823.00
IUUC-Vpa-130503	Vicugna pacos	62.26	0.00e+00	952.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence