iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-097822

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Putative uncharacterized protein DKFZp469K2019

Genbank Nucleotide ID

ABGA01058545

Gene Name

DKFZp469K2019; VHL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000013663.2	ENSPPYT00000015884.2	ENSPPYP00000015275.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	26.72	1.00e-03	40.40	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	99.06	2.00e-88	322.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pongo abelii

Protein Sequence
(Fasta)

MRRRAENWDE AEVGAEEAGV EEYGPEEDGG EESGAEESGP EESGPEELGA EEEMEAGRPR 60
PVLRSVNSRE PSQVIFCNRS PRVVLPVWLN FDGEPQPYPT LPPGTGRRIH SYRGHLWLFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTCCGCCC CGCGTCCGGC CCGCGAATCC CGCGGCCTCT GGCCCGGGTG GTCTGGGCCG 60
CGGAGGGAAT GCGCCGGAGG GCGGAGAACT GGGACGAAGC CGAGGTAGGC GCGGAGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0061428--P:negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0010498--P:proteasomal protein catabolic process
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

KEGG

pon:100173372

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	84.52	2.00e-69	254.00
IUUC-Apl-003580	Anas platyrhynchos	71.05	6.00e-26	108.00
IUUC-Aca-004492	Anolis carolinensis	78.74	3.00e-57	213.00
IUUC-Ang-009806	Aspergillus niger	40.62	1.00e-01	27.70
IUUC-Ame-011818	Astyanax mexicanus	47.24	4.00e-46	177.00
IUUC-Bta-013459	Bos taurus	94.90	3.00e-85	307.00
IUUC-Cel-018173	Caenorhabditis elegans	31.87	8.00e-05	39.70
IUUC-Cja-019826	Callithrix jacchus	98.09	1.00e-87	315.00
IUUC-Cfa-021280	Canis familiaris	95.45	7.00e-84	302.00
IUUC-Cpo-022544	Cavia porcellus	86.59	2.00e-85	307.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	43.33	3.00e-08	52.80
IUUC-Csa-023644	Chlorocebus sabaeus	98.10	2.00e-89	321.00
IUUC-Cho-024479	Choloepus hoffmanni	65.15	6.00e-42	162.00
IUUC-Cin-025505	Ciona intestinalis	27.35	2.00e-05	42.00
IUUC-Cme-027232	Cyanidioschyzon merolae	33.78	1.00e-05	43.50
IUUC-Dre-028350	Danio rerio	53.42	3.00e-33	134.00
IUUC-Dno-029207	Dasypus novemcinctus	87.96	5.00e-52	196.00
IUUC-Dor-030912	Dipodomys ordii	67.11	3.00e-51	194.00
IUUC-Dme-031988	Drosophila melanogaster	26.72	2.00e-05	42.00
IUUC-Eca-034007	Equus caballus	97.50	7.00e-19	84.70
IUUC-Fca-036350	Felis catus	94.87	5.00e-83	300.00
IUUC-Fal-037192	Ficedula albicollis	69.13	1.00e-55	208.00
IUUC-Gmo-038921	Gadus morhua	57.72	4.00e-44	170.00
IUUC-Gga-041016	Gallus gallus	69.72	6.00e-55	206.00
IUUC-Gac-042560	Gasterosteus aculeatus	51.05	1.00e-35	142.00
IUUC-Ggo-045419	Gorilla gorilla	98.12	3.00e-89	320.00
IUUC-Hsa-046547	Homo sapiens	99.06	8.00e-90	322.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	96.15	3.00e-86	310.00
IUUC-Lch-050463	Latimeria chalumnae	65.10	5.00e-54	203.00
IUUC-Loc-052053	Lepisosteus oculatus	57.34	1.00e-47	181.00
IUUC-Laf-053893	Loxodonta africana	92.41	1.00e-83	301.00
IUUC-Mcc-055347	Macaca mulatta	64.49	3.00e-64	237.00
IUUC-Mtr-058490	Medicago truncatula	48.48	6.00e-03	34.30
IUUC-Mdo-062169	Monodelphis domestica	75.53	4.00e-38	149.00
IUUC-Mmu-064366	Mus musculus	94.96	6.00e-76	276.00
IUUC-Mpu-066593	Mustela putorius furo	94.23	2.00e-84	304.00
IUUC-Mlu-066926	Myotis lucifugus	90.27	1.00e-87	315.00
IUUC-Nle-069724	Nomascus leucogenys	98.59	1.00e-90	325.00
IUUC-Opr-070679	Ochotona princeps	78.41	5.00e-76	276.00
IUUC-Ont-071332	Oreochromis niloticus	53.38	4.00e-42	163.00
IUUC-Ola-086869	Oryzias latipes	51.37	1.00e-39	155.00
IUUC-Oga-089124	Otolemur garnettii	95.60	2.00e-85	308.00
IUUC-Oar-089799	Ovis aries	91.92	3.00e-50	189.00
IUUC-Ptr-091186	Pan troglodytes	98.02	3.00e-54	203.00
IUUC-Pan-092150	Papio anubis	95.77	3.00e-87	314.00
IUUC-Psi-094039	Pelodiscus sinensis	67.14	6.00e-52	196.00
IUUC-Pma-094129	Petromyzon marinus	44.06	7.00e-28	116.00
IUUC-Pfo-096892	Poecilia formosa	50.35	5.00e-37	146.00
IUUC-Pca-101058	Procavia capensis	81.86	7.00e-79	286.00
IUUC-Pva-102932	Pteropus vampyrus	97.47	2.00e-88	317.00
IUUC-Rno-105050	Rattus norvegicus	93.67	1.00e-86	311.00
IUUC-Sha-106738	Sarcophilus harrisii	78.00	4.00e-43	165.00
IUUC-Ssc-115973	Sus scrofa	92.99	4.00e-84	303.00
IUUC-Tgu-116663	Taeniopygia guttata	71.28	2.00e-33	132.00
IUUC-Tru-118654	Takifugu rubripes	56.64	1.00e-42	165.00
IUUC-Tca-121306	Theobroma cacao	38.89	3.20e-02	29.60
IUUC-Ttr-128418	Tursiops truncatus	94.94	1.00e-86	311.00
IUUC-Vpa-130268	Vicugna pacos	90.91	2.00e-48	184.00
IUUC-Xtr-132506	Xenopus tropicalis	62.75	4.00e-55	206.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence