iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	19198660
UBD/Alpha-Helix/CUE	CUE	19198660

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	1.70e-15	56.9	229	271

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           ++e++l++++++FPn+d +vi++vLea++g+ +aa+n+LL++ 
   Q: 229  CNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMG 271
           68***************************************96 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).

Protein Sequence
(Fasta)

MATTVSTQRG PVYIGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGAVG TVGRLSITVV 60
QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGTCGGCT ACTGCCGAGC TCTGTGCTTG GGGGAACGCC GAGGTGGGGC GAGGCGGGGC 60
GACTGTCAGC TGACTAAAGA GCCGATTGCC TCGCGGGACA ACGGTCAGCG ACGCAGGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000008--C2_dom
IPR003892--CUE
IPR009060--UBA-like

PROSITE

PS51140--CUE

Pfam

PF00168--C2
PF02845--CUE

SMART

SM00239--C2
SM00546--CUE

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0016604--C:nuclear body
GO:0048471--C:perinuclear region of cytoplasm
GO:0005150--F:interleukin-1, Type I receptor binding
GO:0032183--F:SUMO binding
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0006914--P:autophagy
GO:0030855--P:epithelial cell differentiation
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0016310--P:phosphorylation
GO:0033235--P:positive regulation of protein sumoylation
GO:0036010--P:protein localization to endosome
GO:0007165--P:signal transduction
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:361677

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001566	Ailuropoda melanoleuca	91.63	6.00e-112	396.00
IUUC-Apl-003706	Anas platyrhynchos	90.88	3.00e-120	424.00
IUUC-Aca-004943	Anolis carolinensis	82.12	8.00e-108	382.00
IUUC-Ago-007813	Ashbya gossypii	25.98	2.00e-04	40.00
IUUC-Ame-011082	Astyanax mexicanus	82.91	2.00e-123	434.00
IUUC-Bgr-011976	Blumeria graminis	33.33	3.00e-04	40.00
IUUC-Bta-013259	Bos taurus	92.34	7.00e-118	416.00
IUUC-Bci-013731	Botrytis cinerea	36.11	7.60e-01	28.50
IUUC-Bdi-014407	Brachypodium distachyon	35.71	5.10e-02	31.60
IUUC-Cel-018399	Caenorhabditis elegans	35.58	8.00e-44	170.00
IUUC-Cja-018753	Callithrix jacchus	91.88	1.00e-128	452.00
IUUC-Cfa-020087	Canis familiaris	93.12	2.00e-112	398.00
IUUC-Cpo-021735	Cavia porcellus	86.91	7.00e-117	412.00
IUUC-Csa-023623	Chlorocebus sabaeus	93.41	5.00e-126	443.00
IUUC-Cin-025139	Ciona intestinalis	41.01	6.00e-38	150.00
IUUC-Csv-025877	Ciona savignyi	39.73	4.00e-49	187.00
IUUC-Dre-028691	Danio rerio	81.82	2.00e-112	398.00
IUUC-Dno-029753	Dasypus novemcinctus	89.74	5.00e-110	390.00
IUUC-Dor-030201	Dipodomys ordii	84.98	1.00e-94	339.00
IUUC-Dse-031373	Dothistroma septosporum	29.37	5.00e-07	50.10
IUUC-Ete-032378	Echinops telfairi	87.25	5.00e-95	340.00
IUUC-Eca-034156	Equus caballus	94.30	9.00e-122	429.00
IUUC-Fca-035386	Felis catus	90.91	4.00e-114	404.00
IUUC-Fal-036799	Ficedula albicollis	91.81	2.00e-124	437.00
IUUC-Gmo-038999	Gadus morhua	77.78	5.00e-114	403.00
IUUC-Gga-041068	Gallus gallus	93.43	1.00e-132	465.00
IUUC-Ggo-044809	Gorilla gorilla	77.37	1.00e-92	333.00
IUUC-Hsa-046654	Homo sapiens	93.41	5.00e-126	443.00
IUUC-Itr-048912	Ictidomys tridecemlineatus	97.72	2.00e-123	434.00
IUUC-Lch-049986	Latimeria chalumnae	83.94	5.00e-126	443.00
IUUC-Loc-052419	Lepisosteus oculatus	54.39	6.00e-59	220.00
IUUC-Lma-053222	Leptosphaeria maculans	41.67	1.30e-01	30.80
IUUC-Laf-053390	Loxodonta africana	95.06	2.00e-117	415.00
IUUC-Mcc-054649	Macaca mulatta	92.75	4.00e-119	420.00
IUUC-Meu-056690	Macropus eugenii	95.74	9.00e-73	266.00
IUUC-Mor-057041	Magnaporthe oryzae	47.06	1.10e-02	34.70
IUUC-Mga-059674	Meleagris gallopavo	90.88	2.00e-120	425.00
IUUC-Mvi-060273	Microbotryum violaceum	36.84	6.20e-02	30.80
IUUC-Mmr-060744	Microcebus murinus	92.42	5.00e-119	420.00
IUUC-Mdo-062591	Monodelphis domestica	89.42	5.00e-129	453.00
IUUC-Mmu-063685	Mus musculus	99.64	1.00e-130	458.00
IUUC-Mac-064554	Musa acuminata	26.40	1.00e-07	50.10
IUUC-Mpu-066005	Mustela putorius furo	90.87	8.00e-114	402.00
IUUC-Ncr-068740	Neurospora crassa	42.31	2.00e-04	40.80
IUUC-Nle-069520	Nomascus leucogenys	93.41	5.00e-126	443.00
IUUC-Opr-071036	Ochotona princeps	97.40	2.00e-86	311.00
IUUC-Ont-071379	Oreochromis niloticus	81.52	9.00e-119	419.00
IUUC-Oan-073508	Ornithorhynchus anatinus	94.23	9.00e-59	218.00
IUUC-Ocu-074753	Oryctolagus cuniculus	94.16	4.00e-116	410.00
IUUC-Ola-086417	Oryzias latipes	81.95	2.00e-122	431.00
IUUC-Olu-087609	Ostreococcus lucimarinus	40.00	5.00e-04	38.10
IUUC-Oga-088770	Otolemur garnettii	89.63	5.00e-116	410.00
IUUC-Oar-089528	Ovis aries	49.82	2.00e-32	132.00
IUUC-Pan-091998	Papio anubis	93.41	5.00e-126	443.00
IUUC-Psi-093365	Pelodiscus sinensis	93.13	3.00e-120	424.00
IUUC-Pma-094505	Petromyzon marinus	53.48	4.00e-72	264.00
IUUC-Pfo-096152	Poecilia formosa	82.31	7.00e-124	436.00
IUUC-Pab-097752	Pongo abelii	93.41	5.00e-126	443.00
IUUC-Pop-099461	Populus trichocarpa	45.24	1.30e-01	30.00
IUUC-Pca-100823	Procavia capensis	79.85	2.00e-117	414.00
IUUC-Pva-102815	Pteropus vampyrus	87.75	4.00e-108	384.00
IUUC-Pyt-104628	Pyrenophora triticirepentis	41.18	5.30e-01	28.90
IUUC-Sha-107028	Sarcophilus harrisii	87.10	3.00e-71	259.00
IUUC-Ssl-108621	Sclerotinia sclerotiorum	36.84	4.60e-01	29.30
IUUC-Smo-109303	Selaginella moellendorffii	25.00	1.00e-08	51.60
IUUC-Stu-112916	Solanum tuberosum	30.33	7.00e-11	59.30
IUUC-Sar-113252	Sorex araneus	66.50	3.00e-43	168.00
IUUC-Sre-115062	Sporisorium reilianum	48.48	2.00e-04	40.40
IUUC-Ssc-116217	Sus scrofa	57.53	7.00e-56	210.00
IUUC-Tgu-116503	Taeniopygia guttata	94.53	5.00e-127	446.00
IUUC-Tru-118257	Takifugu rubripes	82.25	4.00e-122	430.00
IUUC-Tni-120576	Tetraodon nigroviridis	76.98	3.00e-112	397.00
IUUC-Tca-121166	Theobroma cacao	28.10	4.00e-07	48.50
IUUC-Tvi-122320	Trichoderma virens	40.62	4.00e-01	29.30
IUUC-Tbe-128094	Tupaia belangeri	92.92	3.00e-102	364.00
IUUC-Ttr-128957	Tursiops truncatus	99.18	1.00e-52	200.00
IUUC-Uma-129647	Ustilago maydis	41.67	6.00e-06	45.80
IUUC-Vda-129734	Verticillium dahliae	44.68	1.00e-03	38.10
IUUC-Xtr-132846	Xenopus tropicalis	82.35	3.00e-112	397.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence