iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-13	50.4	367	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +v++lydy +q+ deL++++G+ +l +  ee ++gW++g+   +g+ Gl P+n+ve 
   Q: 367  RVRALYDYAGQEADELSFRAGEELLKM-SEEDEQGWCQGQ-LQSGRIGLYPANYVEC 421
           689********************9999.999********7.99************86 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAPEEDAGGE VLGGSFWEAG NYRRTVQRVE DGHRLCGDLI SCFQERARIE KAYAQQLADW 60
ARKWRGAVEK GPQYGTLEKA WHAFFTAAER LSELHLEVRE KLHGPDSERV RTWQRGAFHR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAGCGTGAC CAGATTCCCC TAACCCACTG AAGGCCCCTG AGAGGACACG GTGAGTGCTT 60
TGGAGGGGAT GCTGGGGAAC ACGGCGGCGG CGCGGTGGCT CTAGCTCGCT TTCTGGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028523--PACSIN3
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019855--F:calcium channel inhibitor activity
GO:0008289--F:lipid binding
GO:0051926--P:negative regulation of calcium ion transport
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0051044--P:positive regulation of membrane protein ectodomain proteolysis
GO:0030100--P:regulation of endocytosis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001906	Ailuropoda melanoleuca	91.29	0.00e+00	626.00
IUUC-Apl-003211	Anas platyrhynchos	64.19	1.00e-176	612.00
IUUC-Aca-004256	Anolis carolinensis	64.84	2.00e-176	611.00
IUUC-Ame-011049	Astyanax mexicanus	61.04	2.00e-153	535.00
IUUC-Bta-013322	Bos taurus	89.74	0.00e+00	750.00
IUUC-Cja-018907	Callithrix jacchus	92.69	0.00e+00	780.00
IUUC-Cfa-021126	Canis familiaris	91.51	0.00e+00	769.00
IUUC-Cpo-021491	Cavia porcellus	93.87	0.00e+00	800.00
IUUC-Csa-023107	Chlorocebus sabaeus	93.87	0.00e+00	785.00
IUUC-Dre-027933	Danio rerio	60.82	2.00e-145	509.00
IUUC-Dno-029002	Dasypus novemcinctus	92.45	0.00e+00	744.00
IUUC-Eca-033824	Equus caballus	91.98	0.00e+00	775.00
IUUC-Eeu-035122	Erinaceus europaeus	81.87	5.00e-165	573.00
IUUC-Fca-036420	Felis catus	92.69	0.00e+00	784.00
IUUC-Fal-037277	Ficedula albicollis	63.46	5.00e-178	617.00
IUUC-Gga-040941	Gallus gallus	64.11	4.00e-176	610.00
IUUC-Gac-041374	Gasterosteus aculeatus	64.08	3.00e-136	478.00
IUUC-Ggo-045211	Gorilla gorilla	93.63	0.00e+00	784.00
IUUC-Hsa-046053	Homo sapiens	93.87	0.00e+00	785.00
IUUC-Itr-047939	Ictidomys tridecemlineatus	95.28	0.00e+00	806.00
IUUC-Loc-052808	Lepisosteus oculatus	62.19	2.00e-155	542.00
IUUC-Laf-054211	Loxodonta africana	91.75	0.00e+00	742.00
IUUC-Mcc-055044	Macaca mulatta	93.87	0.00e+00	785.00
IUUC-Mga-059216	Meleagris gallopavo	64.05	2.00e-176	612.00
IUUC-Mmr-061172	Microcebus murinus	93.87	0.00e+00	793.00
IUUC-Mdo-062600	Monodelphis domestica	85.85	0.00e+00	745.00
IUUC-Mmu-063218	Mus musculus	98.58	0.00e+00	828.00
IUUC-Mpu-066819	Mustela putorius furo	91.59	0.00e+00	628.00
IUUC-Mlu-067597	Myotis lucifugus	88.63	0.00e+00	756.00
IUUC-Nle-069195	Nomascus leucogenys	93.87	0.00e+00	784.00
IUUC-Opr-071050	Ochotona princeps	92.94	0.00e+00	754.00
IUUC-Ont-071612	Oreochromis niloticus	56.49	2.00e-140	492.00
IUUC-Oan-073256	Ornithorhynchus anatinus	85.45	0.00e+00	719.00
IUUC-Ocu-074653	Oryctolagus cuniculus	94.81	0.00e+00	767.00
IUUC-Oga-089040	Otolemur garnettii	91.98	0.00e+00	784.00
IUUC-Oar-089918	Ovis aries	92.20	0.00e+00	761.00
IUUC-Ptr-091307	Pan troglodytes	93.87	0.00e+00	785.00
IUUC-Pan-092512	Papio anubis	93.87	0.00e+00	785.00
IUUC-Pfo-096881	Poecilia formosa	63.11	1.00e-153	535.00
IUUC-Pab-098620	Pongo abelii	93.87	0.00e+00	785.00
IUUC-Pva-102464	Pteropus vampyrus	89.86	0.00e+00	754.00
IUUC-Sha-107474	Sarcophilus harrisii	86.32	0.00e+00	742.00
IUUC-Ssc-116128	Sus scrofa	92.22	0.00e+00	782.00
IUUC-Tru-118005	Takifugu rubripes	60.18	2.00e-139	488.00
IUUC-Tni-119851	Tetraodon nigroviridis	65.46	4.00e-139	488.00
IUUC-Ttr-129313	Tursiops truncatus	91.27	0.00e+00	776.00
IUUC-Vpa-130760	Vicugna pacos	93.44	4.00e-98	351.00
IUUC-Xtr-132697	Xenopus tropicalis	55.56	7.00e-137	480.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence