iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004139

Ensembl Protein ID

ENSAPLP00000005775.1

UniProt Accession

U3IEV3; U3IEV3_ANAPL

Genbank Protein ID

ENSAPLP00000005775

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADON01022855

Gene Name

LYN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000006127.1	ENSAPLT00000006407.1	ENSAPLP00000005775.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-16	58.7	69	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           v +ly+y++ ++d+L++kkG++++vi   e+ ++W+k+++  ++k+G++P+n+v+k++
   Q: 69   VVALYPYDGLHEDDLSFKKGEKLKVI---EELGEWWKAKSLITKKEGFIPSNYVAKVN 123
           889***********************...8999***********************97 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MGCIKSKRKD NLHGDGLDLK NQPVRKTERT IYVRDPTSNK QQRPAHTEAH LLPGQIFANE 60
DTEEHGVIVV ALYPYDGLHE DDLSFKKGEK LKVIEELGEW WKAKSLITKK EGFIPSNYVA 120

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Nucleotide Sequence
(Fasta)

ATGGGATGTA TAAAATCAAA AAGGAAAGAC AATCTGCATG GAGATGGGCT AGATTTGAAG 60
AATCAACCAG TACGTAAAAC TGAACGAACT ATTTATGTGA GGGATCCAAC GTCCAATAAA 120

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Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0001782--P:B cell homeostasis
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071300--P:cellular response to retinoic acid
GO:0097028--P:dendritic cell differentiation
GO:0030218--P:erythrocyte differentiation
GO:0002774--P:Fc receptor mediated inhibitory signaling pathway
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0031663--P:lipopolysaccharide-mediated signaling pathway
GO:0030889--P:negative regulation of B cell proliferation
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043407--P:negative regulation of MAP kinase activity
GO:0070667--P:negative regulation of mast cell proliferation
GO:0002762--P:negative regulation of myeloid leukocyte differentiation
GO:0034136--P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144--P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175--P:neuron projection development
GO:0002576--P:platelet degranulation
GO:0050861--P:positive regulation of B cell receptor signaling pathway
GO:0030335--P:positive regulation of cell migration
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0070668--P:positive regulation of mast cell proliferation
GO:0010976--P:positive regulation of neuron projection development
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304--P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531--P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0046777--P:protein autophosphorylation
GO:0002902--P:regulation of B cell apoptotic process
GO:0033628--P:regulation of cell adhesion mediated by integrin
GO:0050707--P:regulation of cytokine secretion
GO:0045646--P:regulation of erythrocyte differentiation
GO:0050727--P:regulation of inflammatory response
GO:0043304--P:regulation of mast cell degranulation
GO:0090025--P:regulation of monocyte chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0009725--P:response to hormone
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	88.97	0.00e+00	953.00
IUUC-Aca-004333	Anolis carolinensis	88.44	0.00e+00	945.00
IUUC-Ame-011257	Astyanax mexicanus	77.46	0.00e+00	828.00
IUUC-Bta-013257	Bos taurus	88.20	0.00e+00	947.00
IUUC-Cja-018827	Callithrix jacchus	88.39	0.00e+00	950.00
IUUC-Cfa-020816	Canis familiaris	88.97	0.00e+00	956.00
IUUC-Cpo-021423	Cavia porcellus	88.20	0.00e+00	943.00
IUUC-Csa-024244	Chlorocebus sabaeus	88.01	0.00e+00	941.00
IUUC-Dre-028518	Danio rerio	77.46	0.00e+00	818.00
IUUC-Dno-029322	Dasypus novemcinctus	88.59	0.00e+00	942.00
IUUC-Dor-030706	Dipodomys ordii	78.92	0.00e+00	826.00
IUUC-Eca-034193	Equus caballus	89.17	0.00e+00	956.00
IUUC-Fal-037273	Ficedula albicollis	95.36	0.00e+00	1023.00
IUUC-Gmo-039677	Gadus morhua	74.67	0.00e+00	717.00
IUUC-Gga-040417	Gallus gallus	93.04	0.00e+00	985.00
IUUC-Gac-042490	Gasterosteus aculeatus	70.33	0.00e+00	767.00
IUUC-Ggo-045096	Gorilla gorilla	88.01	0.00e+00	943.00
IUUC-Hsa-046214	Homo sapiens	88.01	0.00e+00	943.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	88.97	0.00e+00	953.00
IUUC-Lch-049991	Latimeria chalumnae	81.70	0.00e+00	859.00
IUUC-Loc-052309	Lepisosteus oculatus	78.85	0.00e+00	845.00
IUUC-Laf-053568	Loxodonta africana	88.59	0.00e+00	949.00
IUUC-Mcc-054849	Macaca mulatta	88.01	0.00e+00	941.00
IUUC-Meu-056170	Macropus eugenii	73.50	0.00e+00	751.00
IUUC-Mmr-061519	Microcebus murinus	87.62	0.00e+00	942.00
IUUC-Mdo-062090	Monodelphis domestica	77.95	0.00e+00	842.00
IUUC-Mmu-063760	Mus musculus	88.97	0.00e+00	948.00
IUUC-Mpu-065677	Mustela putorius furo	88.78	0.00e+00	951.00
IUUC-Mlu-067386	Myotis lucifugus	88.59	0.00e+00	948.00
IUUC-Nle-069742	Nomascus leucogenys	88.01	0.00e+00	940.00
IUUC-Ont-071537	Oreochromis niloticus	73.22	0.00e+00	789.00
IUUC-Oan-073193	Ornithorhynchus anatinus	88.42	0.00e+00	951.00
IUUC-Ocu-074501	Oryctolagus cuniculus	88.78	0.00e+00	949.00
IUUC-Ola-086726	Oryzias latipes	70.46	0.00e+00	771.00
IUUC-Oga-088069	Otolemur garnettii	87.86	0.00e+00	943.00
IUUC-Oar-090091	Ovis aries	88.01	0.00e+00	942.00
IUUC-Ptr-091409	Pan troglodytes	88.01	0.00e+00	943.00
IUUC-Pan-092268	Papio anubis	88.01	0.00e+00	942.00
IUUC-Psi-093685	Pelodiscus sinensis	91.73	0.00e+00	982.00
IUUC-Pfo-096217	Poecilia formosa	72.64	0.00e+00	788.00
IUUC-Pab-098601	Pongo abelii	88.01	0.00e+00	943.00
IUUC-Pva-102160	Pteropus vampyrus	77.99	0.00e+00	811.00
IUUC-Rno-105557	Rattus norvegicus	88.78	0.00e+00	951.00
IUUC-Sha-106643	Sarcophilus harrisii	88.22	0.00e+00	944.00
IUUC-Ssc-116317	Sus scrofa	82.50	0.00e+00	876.00
IUUC-Tgu-116865	Taeniopygia guttata	94.97	0.00e+00	1019.00
IUUC-Tru-118284	Takifugu rubripes	71.43	0.00e+00	776.00
IUUC-Tsy-119440	Tarsius syrichta	84.53	0.00e+00	895.00
IUUC-Tni-120005	Tetraodon nigroviridis	69.81	0.00e+00	757.00
IUUC-Xtr-131907	Xenopus tropicalis	76.44	0.00e+00	788.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence