iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Other/Other	89.33	1.00e-156	549.00	IUUC-Hsa-046922

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.

Protein Sequence
(Fasta)

MSLYPSLEDL KVDKVIQAQT ASSANPASQA FFLNVVDSAA FPPGGNLYPK LYPELSQYMG 60
LSLSEAEICE NMPVVSGAPT QGQLVARPSS VNYMVAPVTG NDAGIRRAEI KQGIREVILC 120

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Nucleotide Sequence
(Fasta)

GGAGCCGGAG CGAGCGGCAG GAACAACGCG GTGTTCGGGG CAGGTGAGCA GCCGCGGGGG 60
TCCCGGACCC CGGCAGGTCT TGGACGCTGA TCGGGCGCTC TGCTCGGGGA TCGGGTAGGT 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0256--Endoplasmic reticulum
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0964--Secreted

Interpro

IPR001478--PDZ
IPR030528--SDCBP

PROSITE

PS50106--PDZ

Pfam

PF00595--PDZ

SMART

SM00228--PDZ

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0070062--C:extracellular exosome
GO:0005925--C:focal adhesion
GO:0005895--C:interleukin-5 receptor complex
GO:0042470--C:melanosome
GO:0045121--C:membrane raft
GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0050839--F:cell adhesion molecule binding
GO:0046875--F:ephrin receptor binding
GO:0001948--F:glycoprotein binding
GO:0019838--F:growth factor binding
GO:0005137--F:interleukin-5 receptor binding
GO:0008289--F:lipid binding
GO:0042043--F:neurexin family protein binding
GO:0008022--F:protein C-terminus binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0045545--F:syndecan binding
GO:0030036--P:actin cytoskeleton organization
GO:0007268--P:chemical synaptic transmission
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0002091--P:negative regulation of receptor internalization
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:0008284--P:positive regulation of cell proliferation
GO:0010718--P:positive regulation of epithelial to mesenchymal transition
GO:0010862--P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0007265--P:Ras protein signal transduction
GO:0007346--P:regulation of mitotic cell cycle

KEGG

rno:83841

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001828	Ailuropoda melanoleuca	87.00	3.00e-153	534.00
IUUC-Apl-003873	Anas platyrhynchos	82.00	7.00e-144	503.00
IUUC-Bta-012904	Bos taurus	86.00	2.00e-153	534.00
IUUC-Bdi-014056	Brachypodium distachyon	27.38	4.50e-02	32.70
IUUC-Cja-019757	Callithrix jacchus	88.33	9.00e-157	545.00
IUUC-Cpo-022386	Cavia porcellus	87.00	9.00e-152	529.00
IUUC-Csa-024043	Chlorocebus sabaeus	86.00	9.00e-149	519.00
IUUC-Dor-030235	Dipodomys ordii	87.63	1.00e-144	505.00
IUUC-Ete-033137	Echinops telfairi	85.67	1.00e-153	535.00
IUUC-Eca-033739	Equus caballus	87.46	2.00e-156	544.00
IUUC-Eeu-034833	Erinaceus europaeus	71.33	2.00e-117	414.00
IUUC-Fca-036103	Felis catus	87.33	9.00e-155	538.00
IUUC-Fal-037584	Ficedula albicollis	80.00	2.00e-141	494.00
IUUC-Gga-040373	Gallus gallus	81.33	2.00e-141	494.00
IUUC-Gac-041533	Gasterosteus aculeatus	64.17	6.00e-112	396.00
IUUC-Ggo-044813	Gorilla gorilla	89.00	5.00e-157	546.00
IUUC-Hsa-046922	Homo sapiens	89.33	6.00e-158	549.00
IUUC-Itr-048546	Ictidomys tridecemlineatus	88.00	3.00e-155	540.00
IUUC-Mga-059793	Meleagris gallopavo	79.15	4.00e-139	487.00
IUUC-Mmr-061366	Microcebus murinus	88.67	2.00e-156	544.00
IUUC-Mmu-064353	Mus musculus	95.67	1.00e-169	588.00
IUUC-Mpu-066678	Mustela putorius furo	88.33	7.00e-156	542.00
IUUC-Mlu-067393	Myotis lucifugus	88.00	2.00e-155	541.00
IUUC-Nle-069522	Nomascus leucogenys	89.33	9.00e-158	549.00
IUUC-Opr-070549	Ochotona princeps	72.00	7.00e-119	419.00
IUUC-Oan-072873	Ornithorhynchus anatinus	72.46	3.00e-121	427.00
IUUC-Ocu-073976	Oryctolagus cuniculus	88.00	1.00e-154	538.00
IUUC-Ola-087243	Oryzias latipes	64.50	2.00e-110	392.00
IUUC-Oga-088683	Otolemur garnettii	88.33	2.00e-155	541.00
IUUC-Pan-091787	Papio anubis	89.67	3.00e-158	550.00
IUUC-Psi-093783	Pelodiscus sinensis	81.33	9.00e-146	509.00
IUUC-Pca-100815	Procavia capensis	86.67	6.00e-151	526.00
IUUC-Pva-102191	Pteropus vampyrus	79.00	4.00e-134	470.00
IUUC-Sha-107239	Sarcophilus harrisii	85.67	1.00e-152	531.00
IUUC-Sar-113431	Sorex araneus	87.67	1.00e-154	538.00
IUUC-Tgu-117393	Taeniopygia guttata	80.33	7.00e-142	496.00
IUUC-Tru-118034	Takifugu rubripes	29.58	2.00e-09	58.20
IUUC-Tsy-119079	Tarsius syrichta	88.33	8.00e-156	542.00
IUUC-Tbe-127482	Tupaia belangeri	79.33	2.00e-134	471.00
IUUC-Ttr-128987	Tursiops truncatus	70.00	4.00e-116	410.00
IUUC-Vpa-130478	Vicugna pacos	64.33	6.00e-102	363.00
IUUC-Xtr-132378	Xenopus tropicalis	74.00	1.00e-133	468.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence