iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089359

Ensembl Protein ID

ENSOARP00000014077.1

UniProt Accession

W5PUE6; W5PUE6_SHEEP

Genbank Protein ID

ENSOARP00000014077

Protein Name

Apoptotic protease-activating factor 1

Genbank Nucleotide ID

AMGL01081824

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000013137.1	ENSOART00000014284.1	ENSOARP00000014077.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.30e-62	205.1	743	778
UBD/Beta-Prp	4.60e-118	393.9	664	916

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gHt+sv+ ++f +d   l+s+s Dgt+k+WD+++ +
   Q: 743  GHTNSVSHCRFsPDdQVLASCSADGTLKLWDVKSAN 778
           8***********77799**************98765 PP

UBD/Beta-Prp

   S: 15   cvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdlstgkcvhtlkghedsvlsls 101
           c +fs d++++at s d+++k+w+  tg l+r + +h+++v+++ f ++++  +l+tgs+D+++k+wdl++ +c  t+ gh++sv  ++
   Q: 664  CCAFSADDRFIATCSVDKKVKIWNSMTGELVRIYDEHSEQVNCCHFTNNSShlLLATGSNDYFLKLWDLNQEECRNTMFGHTNSVSHCR 752
           6789*********************************************9999************************************ PP
   S: 102  fspsgdklvsGshdrtirvwdletgqclee............tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltg 177
           fsp++++l+s s+d t+++wd+++  + ++            +++  + +v c +++ dg +++v++   ++v l+d+ t  ll +   
   Q: 753  FSPDDQVLASCSADGTLKLWDVKSANERKSinvkqfflnseePQEDLEVIVKCCSWSADGaKIMVAA--KNKVFLFDIHTSGLLAEIHM 839
           **************************99999*********999999999***********7777765..46899*************99 PP
   S: 178  ghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsg 254
           gh++ v+  +f++     v +     v+lw++ +g  v  ++gh ++v +v fsp++  +++ s+D+++r+W +++ 
   Q: 840  GHHSTVQYCDFSPHNHLAVVALSQYCVELWSMDSGLKVADCRGHLSWVHCVMFSPDGSSFLTSSDDQTVRLWETKKV 916
           9************8766666666778**********************************************75543 PP

Organism

Ovis aries

Functional Description
(View)

Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.

Protein Sequence
(Fasta)

GKMDAKARNC LLQHREALER DIKTSYIMDH MISNGVLTVS EEEKVKNEPT QRQRAAMLIK 60
MILKKDNHSY ISFYNALLHE GYKDLAALLH GGIPVVSSSD GKDSVSGITS YVRTVLCEGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTGGGTTC TCCGGAGGTT CAGTAGCCAG TTTAAGGGAC TTAGAATTCT CGTTCAAGGG 60
ATATTTGTTA ATCACTCTAA TACTGTACCA GGAAGAGAAA TGTCTAAAAA GGAACTGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR017251--Apaf-1
IPR024977--Apc4_WD40_dom
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00619--CARD
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	90.75	0.00e+00	2348.00
IUUC-Apl-004201	Anas platyrhynchos	70.66	0.00e+00	1847.00
IUUC-Aca-004638	Anolis carolinensis	69.03	0.00e+00	1837.00
IUUC-Ani-009285	Aspergillus nidulans	27.59	4.00e-67	250.00
IUUC-Ame-011062	Astyanax mexicanus	55.39	0.00e+00	1399.00
IUUC-Bta-012865	Bos taurus	97.92	0.00e+00	2565.00
IUUC-Cja-018815	Callithrix jacchus	80.48	0.00e+00	2058.00
IUUC-Cfa-020222	Canis familiaris	86.05	0.00e+00	2202.00
IUUC-Cpo-021524	Cavia porcellus	87.91	0.00e+00	2291.00
IUUC-Csa-023861	Chlorocebus sabaeus	90.15	0.00e+00	2326.00
IUUC-Cho-024484	Choloepus hoffmanni	79.18	0.00e+00	1213.00
IUUC-Dre-028006	Danio rerio	53.96	0.00e+00	1290.00
IUUC-Dno-029591	Dasypus novemcinctus	91.03	0.00e+00	2387.00
IUUC-Dor-030237	Dipodomys ordii	74.12	0.00e+00	1081.00
IUUC-Ete-032620	Echinops telfairi	84.68	0.00e+00	1098.00
IUUC-Eca-033569	Equus caballus	89.76	0.00e+00	2350.00
IUUC-Eeu-035354	Erinaceus europaeus	65.90	0.00e+00	635.00
IUUC-Fca-036337	Felis catus	91.28	0.00e+00	2393.00
IUUC-Fal-037077	Ficedula albicollis	70.62	0.00e+00	1848.00
IUUC-Gmo-039687	Gadus morhua	51.69	0.00e+00	941.00
IUUC-Ggr-039828	Gaeumannomyces graminis	23.15	1.00e-40	162.00
IUUC-Gga-040299	Gallus gallus	69.30	0.00e+00	1855.00
IUUC-Gac-041762	Gasterosteus aculeatus	52.72	0.00e+00	1296.00
IUUC-Ggo-045563	Gorilla gorilla	90.49	0.00e+00	2341.00
IUUC-Hsa-046771	Homo sapiens	90.15	0.00e+00	2329.00
IUUC-Lch-050200	Latimeria chalumnae	65.81	0.00e+00	1670.00
IUUC-Loc-052090	Lepisosteus oculatus	59.95	0.00e+00	1544.00
IUUC-Laf-053861	Loxodonta africana	89.68	0.00e+00	2339.00
IUUC-Mcc-055543	Macaca mulatta	90.55	0.00e+00	2335.00
IUUC-Meu-056688	Macropus eugenii	80.19	0.00e+00	2061.00
IUUC-Mga-059243	Meleagris gallopavo	70.07	0.00e+00	1874.00
IUUC-Mmr-061134	Microcebus murinus	84.80	0.00e+00	1990.00
IUUC-Mdo-062913	Monodelphis domestica	78.59	0.00e+00	2053.00
IUUC-Mmu-063811	Mus musculus	87.11	0.00e+00	2298.00
IUUC-Mpu-066780	Mustela putorius furo	90.56	0.00e+00	2326.00
IUUC-Mlu-067276	Myotis lucifugus	90.10	0.00e+00	2380.00
IUUC-Nfi-068459	Neosartorya fischeri	26.09	2.00e-59	224.00
IUUC-Nle-069129	Nomascus leucogenys	89.99	0.00e+00	2323.00
IUUC-Opr-071007	Ochotona princeps	65.69	0.00e+00	1111.00
IUUC-Ont-071348	Oreochromis niloticus	55.48	0.00e+00	1417.00
IUUC-Oan-072717	Ornithorhynchus anatinus	80.43	0.00e+00	2125.00
IUUC-Ocu-074286	Oryctolagus cuniculus	89.17	0.00e+00	1983.00
IUUC-Ola-086895	Oryzias latipes	50.33	0.00e+00	1196.00
IUUC-Oga-088678	Otolemur garnettii	89.11	0.00e+00	2310.00
IUUC-Ptr-091062	Pan troglodytes	90.15	0.00e+00	2330.00
IUUC-Pan-092528	Papio anubis	92.85	0.00e+00	1377.00
IUUC-Psi-093430	Pelodiscus sinensis	75.14	0.00e+00	1975.00
IUUC-Pma-094690	Petromyzon marinus	37.52	4.00e-145	508.00
IUUC-Pfo-097204	Poecilia formosa	54.96	0.00e+00	1392.00
IUUC-Pab-097690	Pongo abelii	90.39	0.00e+00	2336.00
IUUC-Pca-100778	Procavia capensis	69.79	0.00e+00	1174.00
IUUC-Pva-102870	Pteropus vampyrus	87.53	0.00e+00	2107.00
IUUC-Rno-104889	Rattus norvegicus	86.47	0.00e+00	2258.00
IUUC-Sha-107465	Sarcophilus harrisii	78.98	0.00e+00	2105.00
IUUC-Sar-113268	Sorex araneus	87.75	0.00e+00	660.00
IUUC-Ssc-115654	Sus scrofa	91.91	0.00e+00	2422.00
IUUC-Tgu-117302	Taeniopygia guttata	70.78	0.00e+00	1863.00
IUUC-Tru-118363	Takifugu rubripes	54.61	0.00e+00	1387.00
IUUC-Tsy-119007	Tarsius syrichta	85.35	0.00e+00	2213.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.32	0.00e+00	1336.00
IUUC-Tur-126636	Triticum urartu	23.39	9.00e-24	106.00
IUUC-Tbe-127413	Tupaia belangeri	76.13	0.00e+00	1407.00
IUUC-Ttr-129213	Tursiops truncatus	85.91	0.00e+00	2201.00
IUUC-Vpa-130146	Vicugna pacos	86.67	0.00e+00	1668.00
IUUC-Xtr-132559	Xenopus tropicalis	61.77	0.00e+00	1583.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence