iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-106805

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEFK01134319

Gene Name

USP13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017431.1	ENSSHAT00000020720.1	ENSSHAP00000020556.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-39	136.7	279	423
UBD/Alpha-Helix/UBA	4.80e-19	68.0	662	699

Active Site

Position(s)	Description	Evidence
288	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
758	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG++NlgN+CY+  v+Q++++ipe+++++   +  ++ + +p +p++++ ++++kl + l                       k +++ 
   Q: 279  TGMRNLGNSCYLSVVMQAIFSIPEFQRMYVG-NLARIFDYSPLDPTQDFNTQMAKLGHGLlsgqyskppmkselieqvmkeeHKPQQNG 366
           7******************************.66666677789****************98888888888888777765543378888* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedks 124
           +sp ++++ ++k ++efs+++qqDaqEf+ +l++ +e+e +++++k++ee++  +++
   Q: 367  ISPCMFKAFVSKSHPEFSSNRQQDAQEFFLHLVNLVERERERREEKRREEKRRGEER 423
           ****************************************88777777777665544 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e++++ +++MGF r +a+qaL a+nnnle+A+++++++
   Q: 662  EEIVAIITSMGFQRTQAVQALKATNNNLERALDWIFSH 699
           899*********************************97 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

SEGGLYVCMN TFLAFGREHV ERHYRKTGQC VYMHLKRHVR EKVTGASGGV LPQRRNPKLF 60
LDLEMTGDLN SDDYEYEDEA KLVIFPDHYE IALPNIEELP ALVTIACDAV LNSKSPYRKQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCAGAAGGAG GTCTCTATGT GTGCATGAAT ACGTTCCTGG CCTTTGGAAG GGAACATGTT 60
GAAAGGCACT ATCGGAAAAC TGGACAGTGT GTGTACATGC ATCTGAAAAG ACATGTAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904454--F:ubiquitin-specific protease activity involved in positive regulation of ERAD pathway
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:1904378--P:maintenance of unfolded protein involved in ERAD pathway
GO:0035523--P:protein K29-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019021	Callithrix jacchus	73.52	0.00e+00	1076.00
IUUC-Eeu-034612	Erinaceus europaeus	81.09	0.00e+00	677.00
IUUC-Meu-056361	Macropus eugenii	78.29	0.00e+00	1133.00
IUUC-Mdo-062302	Monodelphis domestica	84.73	0.00e+00	1296.00
IUUC-Mlu-067786	Myotis lucifugus	68.51	0.00e+00	1020.00
IUUC-Opr-070578	Ochotona princeps	77.56	3.00e-156	545.00
IUUC-Oan-072959	Ornithorhynchus anatinus	87.45	2.00e-128	450.00
IUUC-Sar-113733	Sorex araneus	86.32	0.00e+00	706.00
IUUC-Ssc-115693	Sus scrofa	87.53	0.00e+00	644.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence