iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067168

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02026868

Gene Name

RNF41

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006057.2	ENSMLUT00000006056.2	ENSMLUP00000005531.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.10e-06	27.6	18	57
E3 activity/RING/U-box	1.10e-06	28.6	12	69

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   +++ p+  p C H+f+  C+ +w       s++++CP++r
   Q: 18   CPICSGVLEE-PVQAPhCEHAFCNACITQW------FSQQQTCPVDR 57
           ****999999.777777*************......********987 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
           v e+++CpI   + ++Pv +p + + +  ++I +w++++++ cPv+r+ +t   l P  
   Q: 12   VDEDLICPICSGVLEEPVQAPhCEHAFCNACITQWFSQQQT-CPVDRSVVTVAHLRPVP 69
           56899******************************998887.******99998887764 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 60
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGTATG ATGTAACCCG CTTCCAGGGG GATGTTGACG AAGATCTTAT CTGTCCTATT 60
TGCAGTGGAG TCTTGGAGGA GCCAGTCCAG GTGAGTCGGT CTGCTGGCAG GTGTAGTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR013010--Znf_SIAH

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF08941--USP8_interact

SMART

SM00184--RING

Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0031386--F:protein tag
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:1901525--P:negative regulation of macromitophagy
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010498--P:proteasomal protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:2000114--P:regulation of establishment of cell polarity
GO:0045619--P:regulation of lymphocyte differentiation
GO:0043408--P:regulation of MAPK cascade
GO:0045637--P:regulation of myeloid cell differentiation
GO:0051896--P:regulation of protein kinase B signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002398	Ailuropoda melanoleuca	99.37	0.00e+00	659.00
IUUC-Apl-003568	Anas platyrhynchos	95.28	0.00e+00	630.00
IUUC-Aca-005119	Anolis carolinensis	95.90	0.00e+00	642.00
IUUC-Ame-010708	Astyanax mexicanus	90.22	2.00e-178	617.00
IUUC-Bta-013428	Bos taurus	93.38	1.00e-178	618.00
IUUC-Cja-019844	Callithrix jacchus	98.74	0.00e+00	653.00
IUUC-Cfa-021124	Canis familiaris	99.05	0.00e+00	658.00
IUUC-Cpo-022325	Cavia porcellus	98.74	0.00e+00	657.00
IUUC-Csa-023113	Chlorocebus sabaeus	99.05	0.00e+00	658.00
IUUC-Cho-024991	Choloepus hoffmanni	97.94	2.00e-113	400.00
IUUC-Cne-026870	Cryptococcus neoformans	38.52	4.00e-20	93.20
IUUC-Dre-028730	Danio rerio	89.91	5.00e-178	616.00
IUUC-Dno-028908	Dasypus novemcinctus	99.30	8.00e-172	595.00
IUUC-Dor-030411	Dipodomys ordii	98.74	0.00e+00	657.00
IUUC-Dme-031868	Drosophila melanogaster	57.78	2.00e-111	394.00
IUUC-Ete-032896	Echinops telfairi	81.51	3.00e-125	440.00
IUUC-Eca-034135	Equus caballus	99.05	0.00e+00	658.00
IUUC-Eeu-034675	Erinaceus europaeus	98.74	0.00e+00	656.00
IUUC-Fca-035612	Felis catus	99.05	0.00e+00	658.00
IUUC-Fal-036922	Ficedula albicollis	95.06	1.00e-41	160.00
IUUC-Gmo-039648	Gadus morhua	87.38	3.00e-172	597.00
IUUC-Gga-040474	Gallus gallus	96.21	0.00e+00	644.00
IUUC-Gac-041951	Gasterosteus aculeatus	88.33	1.00e-174	605.00
IUUC-Ggo-045126	Gorilla gorilla	98.74	0.00e+00	653.00
IUUC-Hsa-046402	Homo sapiens	99.05	0.00e+00	658.00
IUUC-Itr-047895	Ictidomys tridecemlineatus	99.05	0.00e+00	658.00
IUUC-Lch-050266	Latimeria chalumnae	92.74	0.00e+00	628.00
IUUC-Loc-052547	Lepisosteus oculatus	91.17	4.00e-179	620.00
IUUC-Laf-054332	Loxodonta africana	98.43	0.00e+00	653.00
IUUC-Mcc-055869	Macaca mulatta	99.05	0.00e+00	658.00
IUUC-Meu-056735	Macropus eugenii	98.95	1.00e-171	594.00
IUUC-Mga-060100	Meleagris gallopavo	96.21	0.00e+00	644.00
IUUC-Mmr-061382	Microcebus murinus	99.05	0.00e+00	658.00
IUUC-Mmu-064225	Mus musculus	98.74	0.00e+00	657.00
IUUC-Mpu-066709	Mustela putorius furo	99.05	0.00e+00	658.00
IUUC-Nle-070176	Nomascus leucogenys	99.05	0.00e+00	658.00
IUUC-Opr-070259	Ochotona princeps	98.74	0.00e+00	657.00
IUUC-Ont-071235	Oreochromis niloticus	89.59	7.00e-177	612.00
IUUC-Oan-072850	Ornithorhynchus anatinus	58.81	6.00e-91	327.00
IUUC-Ocu-074165	Oryctolagus cuniculus	98.74	0.00e+00	657.00
IUUC-Ola-086658	Oryzias latipes	88.33	2.00e-173	600.00
IUUC-Oga-088933	Otolemur garnettii	99.05	0.00e+00	658.00
IUUC-Oar-090089	Ovis aries	98.74	0.00e+00	657.00
IUUC-Ptr-091263	Pan troglodytes	99.05	0.00e+00	658.00
IUUC-Pan-092926	Papio anubis	99.05	0.00e+00	658.00
IUUC-Psi-093934	Pelodiscus sinensis	88.68	1.00e-167	582.00
IUUC-Pma-094578	Petromyzon marinus	68.97	1.00e-126	446.00
IUUC-Pfo-097431	Poecilia formosa	89.59	1.00e-176	611.00
IUUC-Pab-097852	Pongo abelii	99.05	0.00e+00	658.00
IUUC-Pca-100496	Procavia capensis	90.88	2.00e-168	584.00
IUUC-Pva-103157	Pteropus vampyrus	97.50	9.00e-116	408.00
IUUC-Rno-105928	Rattus norvegicus	98.74	0.00e+00	656.00
IUUC-Sha-107556	Sarcophilus harrisii	98.43	0.00e+00	651.00
IUUC-Sar-113208	Sorex araneus	99.05	0.00e+00	658.00
IUUC-Ssc-116011	Sus scrofa	98.74	0.00e+00	657.00
IUUC-Tgu-116882	Taeniopygia guttata	73.50	9.00e-73	265.00
IUUC-Tru-117987	Takifugu rubripes	89.27	4.00e-176	610.00
IUUC-Tsy-118785	Tarsius syrichta	98.74	0.00e+00	652.00
IUUC-Tni-120165	Tetraodon nigroviridis	89.59	2.00e-176	610.00
IUUC-Tbe-127920	Tupaia belangeri	98.00	6.00e-118	416.00
IUUC-Ttr-129160	Tursiops truncatus	98.42	0.00e+00	655.00
IUUC-Vpa-130629	Vicugna pacos	99.05	0.00e+00	658.00
IUUC-Xtr-131895	Xenopus tropicalis	95.27	0.00e+00	637.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence