iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Disease-associated Variation
GWASdb	GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	5.80e-18	66.7	33	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           aDv+l vgg+e ++h+  La sS++F+a+f +++ es  + +ve++dv+p v+ +l++F+Ytg+l++
   Q: 33   ADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESF-SARVELRDVEPAVVGQLVDFVYTGRLTI 98
           7************************************9.*************************986 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MVRNVDDLDF HLPSHAQDML DGLQRLRSQP KLADVTLLVG GRELPCHRGL LALSSPYFHA 60
MFAGDFAESF SARVELRDVE PAVVGQLVDF VYTGRLTITQ GNVEALTRTA ARLHFPSVQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTGTTCTC AGCTTCGAGG TCCAGGCTGA GTGAGAGGTA GGATCCAGGG GGCTCTGGGG 60
CAGGGGACAG CAGAGAGGGC AGGGGGAACC CAGCCAGGAG CAGCGGGGAG GGTGGGTTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0016567--P:protein ubiquitination

KEGG

hsa:377007

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002196	Ailuropoda melanoleuca	90.72	0.00e+00	1044.00
IUUC-Apl-003670	Anas platyrhynchos	55.38	7.00e-178	617.00
IUUC-Aca-005190	Anolis carolinensis	66.27	0.00e+00	827.00
IUUC-Afu-008898	Aspergillus fumigatus	33.77	3.00e-08	52.40
IUUC-Ame-011820	Astyanax mexicanus	55.37	0.00e+00	654.00
IUUC-Cja-019113	Callithrix jacchus	95.16	0.00e+00	1084.00
IUUC-Cfa-020904	Canis familiaris	90.33	0.00e+00	1071.00
IUUC-Cpo-022318	Cavia porcellus	87.56	0.00e+00	1026.00
IUUC-Csa-024097	Chlorocebus sabaeus	95.85	0.00e+00	1133.00
IUUC-Dre-028516	Danio rerio	54.33	3.00e-176	611.00
IUUC-Dno-029883	Dasypus novemcinctus	73.15	0.00e+00	791.00
IUUC-Dor-031000	Dipodomys ordii	86.70	0.00e+00	1015.00
IUUC-Dse-031291	Dothistroma septosporum	30.00	6.00e-06	44.70
IUUC-Ete-032400	Echinops telfairi	75.50	3.00e-126	444.00
IUUC-Eca-033876	Equus caballus	89.85	0.00e+00	1057.00
IUUC-Fca-035580	Felis catus	83.02	0.00e+00	947.00
IUUC-Fal-037157	Ficedula albicollis	63.40	0.00e+00	770.00
IUUC-Gmo-039662	Gadus morhua	56.83	2.00e-92	333.00
IUUC-Gga-040593	Gallus gallus	54.55	0.00e+00	630.00
IUUC-Gac-041694	Gasterosteus aculeatus	56.03	0.00e+00	633.00
IUUC-Ggo-045304	Gorilla gorilla	98.10	0.00e+00	1107.00
IUUC-Itr-049035	Ictidomys tridecemlineatus	89.62	0.00e+00	1061.00
IUUC-Lch-050363	Latimeria chalumnae	58.23	0.00e+00	692.00
IUUC-Loc-052156	Lepisosteus oculatus	58.21	0.00e+00	687.00
IUUC-Laf-054147	Loxodonta africana	80.68	0.00e+00	889.00
IUUC-Mcc-055081	Macaca mulatta	97.06	0.00e+00	1147.00
IUUC-Meu-056358	Macropus eugenii	69.83	0.00e+00	844.00
IUUC-Mmr-060941	Microcebus murinus	90.66	0.00e+00	1069.00
IUUC-Mdo-061803	Monodelphis domestica	72.40	0.00e+00	733.00
IUUC-Mmu-063701	Mus musculus	87.26	0.00e+00	1035.00
IUUC-Mpu-065684	Mustela putorius furo	90.50	0.00e+00	1043.00
IUUC-Mlu-067099	Myotis lucifugus	88.26	0.00e+00	1025.00
IUUC-Nle-069400	Nomascus leucogenys	83.43	0.00e+00	781.00
IUUC-Opr-070451	Ochotona princeps	76.74	3.00e-142	498.00
IUUC-Ont-071829	Oreochromis niloticus	54.50	1.00e-179	623.00
IUUC-Oan-073264	Ornithorhynchus anatinus	69.25	3.00e-155	541.00
IUUC-Ocu-074948	Oryctolagus cuniculus	91.33	0.00e+00	900.00
IUUC-Ola-086576	Oryzias latipes	55.33	0.00e+00	640.00
IUUC-Oga-088677	Otolemur garnettii	91.00	0.00e+00	1079.00
IUUC-Ptr-091010	Pan troglodytes	84.54	4.00e-137	481.00
IUUC-Pan-092729	Papio anubis	88.41	0.00e+00	1017.00
IUUC-Psi-093394	Pelodiscus sinensis	66.72	0.00e+00	810.00
IUUC-Pfo-096444	Poecilia formosa	54.22	6.00e-175	607.00
IUUC-Pab-098354	Pongo abelii	81.83	0.00e+00	871.00
IUUC-Pca-100208	Procavia capensis	82.73	0.00e+00	924.00
IUUC-Pva-102570	Pteropus vampyrus	85.99	0.00e+00	983.00
IUUC-Rno-105977	Rattus norvegicus	87.09	0.00e+00	1045.00
IUUC-Sha-106893	Sarcophilus harrisii	70.73	0.00e+00	848.00
IUUC-Ssl-108438	Sclerotinia sclerotiorum	40.32	5.00e-06	44.70
IUUC-Sar-113475	Sorex araneus	78.55	3.00e-125	442.00
IUUC-Sre-115185	Sporisorium reilianum	41.18	1.60e-01	29.60
IUUC-Ssc-116326	Sus scrofa	87.16	0.00e+00	1036.00
IUUC-Tgu-117525	Taeniopygia guttata	65.33	0.00e+00	777.00
IUUC-Tru-118726	Takifugu rubripes	49.33	2.00e-174	605.00
IUUC-Tsy-119226	Tarsius syrichta	95.73	5.00e-132	464.00
IUUC-Tni-120247	Tetraodon nigroviridis	52.90	4.00e-178	617.00
IUUC-Tbe-127524	Tupaia belangeri	93.75	2.00e-139	489.00
IUUC-Ttr-129202	Tursiops truncatus	89.27	0.00e+00	1015.00
IUUC-Xtr-131902	Xenopus tropicalis	56.72	0.00e+00	671.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence