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Tag Content
UUCD2 ID IUUC-Bta-013194
UUCD1 version UUC-BoT-00385
Ensembl Protein ID ENSBTAP00000027942.5
UniProt Accession Q3ZC24; MARH5_BOVIN
Genbank Protein ID AAI02967.1
Protein Name E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING-type E3 ubiquitin transferase MARCH5
Genbank Nucleotide ID BC102966
Gene Name MARCH5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000020981.5 ENSBTAT00000027942.5 ENSBTAP00000027942.5
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 6.80e-12 45.5 2 59
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 3    vClvCgeggedek...slveCek..CrewfHpaClklsveeelpnsek..wiCpkCrs 53
           +C+vC++++ed++   ++  C++  +++w+H+aCl+++v+e+++++++  ++Cp+C++
   Q: 2    SCWVCFATDEDDRtaeWVRPCRCrgSTKWVHQACLQRWVDEKQRGNSTarVACPQCNA 59
           7***********7778******999*********************9999******97 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
 Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Protein Sequence
(Fasta)
RSCWVCFATD EDDRTAEWVR PCRCRGSTKW VHQACLQRWV DEKQRGNSTA RVACPQCNAE 60
YLIVFPKLGP VVYVLDLADR LISKACPFAA AGIMVGSIYW TAVTYGAVTV MQVVGHKEGL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013194|E3,PHD|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGAAGTTGCT GGGTGTGTTT TGCCACTGAT GAAGATGATA GAACAGCTGA ATGGGTGAGA 60
CCGTGCAGAT GCAGAGGATC TACAAAATGG GTTCACCAGG CTTGTTTACA GCGCTGGGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013194|E3,PHD|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51292--ZF_RING_CH
Pfam

PF12906--RINGv
SMART

SM00744--RINGv
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090344--P:negative regulation of cell aging
GO:0051865--P:protein autoubiquitination
GO:0090140--P:regulation of mitochondrial fission
KEGG bta:540937
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002055 Ailuropoda melanoleuca 100.00 3.00e-159 553.00
IUUC-Apl-004106 Anas platyrhynchos 99.25 2.00e-157 547.00
IUUC-Aca-004615 Anolis carolinensis 99.25 3.00e-157 546.00
IUUC-Acl-008017 Aspergillus clavatus 26.47 2.00e-10 60.10
IUUC-Afl-008538 Aspergillus flavus 22.22 1.00e-05 44.30
IUUC-Afu-008855 Aspergillus fumigatus 24.81 2.00e-10 60.80
IUUC-Ang-009850 Aspergillus niger 24.24 3.00e-09 56.20
IUUC-Ate-010339 Aspergillus terreus 26.25 1.00e-11 64.30
IUUC-Ame-011363 Astyanax mexicanus 99.25 9.00e-159 552.00
IUUC-Bgr-012038 Blumeria graminis 30.30 7.00e-08 52.40
IUUC-Bci-013963 Botrytis cinerea 25.83 4.00e-08 52.80
IUUC-Bdi-014566 Brachypodium distachyon 43.06 8.00e-09 53.90
IUUC-Cel-018634 Caenorhabditis elegans 42.62 2.00e-09 55.10
IUUC-Cja-019097 Callithrix jacchus 98.13 5.00e-157 546.00
IUUC-Cfa-020404 Canis familiaris 99.25 4.00e-158 550.00
IUUC-Cpo-022094 Cavia porcellus 100.00 1.00e-159 555.00
IUUC-Csa-023955 Chlorocebus sabaeus 100.00 1.00e-159 555.00
IUUC-Cho-024819 Choloepus hoffmanni 94.98 1.00e-118 418.00
IUUC-Cin-025730 Ciona intestinalis 60.59 1.00e-98 352.00
IUUC-Csv-025975 Ciona savignyi 59.11 2.00e-97 348.00
IUUC-Dre-027676 Danio rerio 98.50 1.00e-157 548.00
IUUC-Dno-029876 Dasypus novemcinctus 99.63 3.00e-159 553.00
IUUC-Dor-030204 Dipodomys ordii 95.96 5.00e-106 376.00
IUUC-Dse-031226 Dothistroma septosporum 25.84 3.00e-10 60.10
IUUC-Dme-031751 Drosophila melanogaster 53.68 5.00e-83 301.00
IUUC-Ete-032941 Echinops telfairi 100.00 1.00e-159 555.00
IUUC-Eca-033559 Equus caballus 100.00 1.00e-159 555.00
IUUC-Eeu-034761 Erinaceus europaeus 97.37 1.00e-153 535.00
IUUC-Fca-035951 Felis catus 100.00 1.00e-159 555.00
IUUC-Fal-036756 Ficedula albicollis 99.25 2.00e-158 550.00
IUUC-Fox-037934 Fusarium oxysporum 28.46 1.00e-07 51.20
IUUC-Fso-038122 Fusarium solani 28.81 7.00e-09 55.50
IUUC-Gmo-038695 Gadus morhua 93.23 4.00e-147 513.00
IUUC-Gga-040911 Gallus gallus 99.25 2.00e-158 550.00
IUUC-Gac-042449 Gasterosteus aculeatus 96.25 8.00e-154 535.00
IUUC-Ggo-045555 Gorilla gorilla 100.00 1.00e-159 555.00
IUUC-Hsa-046302 Homo sapiens 100.00 1.00e-159 555.00
IUUC-Itr-048942 Ictidomys tridecemlineatus 100.00 1.00e-159 555.00
IUUC-Kpa-049406 Komagataella pastoris 22.41 1.00e-02 34.70
IUUC-Lch-050077 Latimeria chalumnae 98.11 2.00e-156 544.00
IUUC-Loc-052045 Lepisosteus oculatus 99.63 2.00e-159 554.00
IUUC-Lma-053141 Leptosphaeria maculans 25.71 2.00e-08 53.90
IUUC-Laf-053982 Loxodonta africana 99.63 2.00e-157 547.00
IUUC-Mcc-055278 Macaca mulatta 100.00 1.00e-159 555.00
IUUC-Meu-056185 Macropus eugenii 99.25 5.00e-157 546.00
IUUC-Mor-057070 Magnaporthe oryzae 26.04 2.00e-07 50.80
IUUC-Mpo-057293 Magnaporthe poae 23.97 2.00e-05 44.30
IUUC-Mla-059023 Melampsora laricipopulina 25.19 1.00e-06 48.50
IUUC-Mga-060064 Meleagris gallopavo 97.06 3.00e-156 543.00
IUUC-Mvi-060427 Microbotryum violaceum 28.21 1.00e-06 48.50
IUUC-Mmr-060872 Microcebus murinus 100.00 1.00e-159 555.00
IUUC-Mdo-062907 Monodelphis domestica 100.00 1.00e-159 555.00
IUUC-Mmu-063792 Mus musculus 100.00 1.00e-159 555.00
IUUC-Mpu-065948 Mustela putorius furo 100.00 2.00e-159 554.00
IUUC-Mlu-067399 Myotis lucifugus 100.00 4.00e-159 553.00
IUUC-Nfi-068312 Neosartorya fischeri 25.00 2.00e-10 60.80
IUUC-Ncr-068837 Neurospora crassa 30.83 4.00e-12 66.60
IUUC-Nle-069197 Nomascus leucogenys 100.00 1.00e-159 555.00
IUUC-Opr-070474 Ochotona princeps 92.88 7.00e-145 506.00
IUUC-Ont-071896 Oreochromis niloticus 47.58 1.00e-72 266.00
IUUC-Oan-073425 Ornithorhynchus anatinus 99.25 1.00e-158 551.00
IUUC-Ocu-074127 Oryctolagus cuniculus 100.00 1.00e-159 555.00
IUUC-Ola-086561 Oryzias latipes 98.50 2.00e-156 544.00
IUUC-Oga-089004 Otolemur garnettii 100.00 9.00e-160 555.00
IUUC-Oar-089485 Ovis aries 100.00 9.00e-159 551.00
IUUC-Ptr-091645 Pan troglodytes 100.00 1.00e-159 555.00
IUUC-Pan-092408 Papio anubis 100.00 1.00e-159 555.00
IUUC-Psi-093325 Pelodiscus sinensis 94.01 1.00e-147 515.00
IUUC-Pma-094495 Petromyzon marinus 85.00 7.00e-87 312.00
IUUC-Pno-094820 Phaeosphaeria nodorum 26.40 2.00e-08 54.30
IUUC-Pfo-097381 Poecilia formosa 97.75 8.00e-156 542.00
IUUC-Pab-097888 Pongo abelii 100.00 1.00e-159 555.00
IUUC-Pva-102265 Pteropus vampyrus 100.00 1.00e-159 555.00
IUUC-Pgr-103326 Puccinia graminis 24.11 2.00e-02 34.30
IUUC-Pte-104347 Pyrenophora teres 26.97 7.00e-10 58.90
IUUC-Pyt-104598 Pyrenophora triticirepentis 38.00 6.00e-07 48.10
IUUC-Rno-105983 Rattus norvegicus 100.00 1.00e-159 555.00
IUUC-Sha-106483 Sarcophilus harrisii 100.00 3.00e-159 553.00
IUUC-Sja-107897 Schizosaccharomyces japonicus 28.05 3.00e-05 42.70
IUUC-Spo-108227 Schizosaccharomyces pombe 28.21 3.00e-05 42.70
IUUC-Sar-113087 Sorex araneus 96.24 6.00e-152 529.00
IUUC-Sre-114892 Sporisorium reilianum 26.67 8.00e-14 72.00
IUUC-Ssc-115964 Sus scrofa 100.00 1.00e-159 555.00
IUUC-Tgu-117325 Taeniopygia guttata 99.25 5.00e-158 549.00
IUUC-Tru-118291 Takifugu rubripes 99.44 8.00e-105 372.00
IUUC-Tsy-119454 Tarsius syrichta 83.08 5.00e-127 446.00
IUUC-Tni-119754 Tetraodon nigroviridis 95.85 3.00e-148 517.00
IUUC-Tre-122138 Trichoderma reesei 32.52 2.00e-08 54.30
IUUC-Tvi-122629 Trichoderma virens 31.97 5.00e-09 55.50
IUUC-Tbe-127988 Tupaia belangeri 100.00 8.00e-136 475.00
IUUC-Ttr-128413 Tursiops truncatus 100.00 1.00e-135 474.00
IUUC-Uma-129544 Ustilago maydis 26.90 9.00e-16 78.60
IUUC-Vda-129998 Verticillium dahliae 29.57 2.00e-07 50.40
IUUC-Vpa-130036 Vicugna pacos 96.63 3.00e-153 534.00
IUUC-Xtr-131932 Xenopus tropicalis 96.64 2.00e-153 534.00
IUUC-Xma-134072 Xiphophorus maculatus 97.75 8.00e-156 542.00
IUUC-Zma-135012 Zea mays 46.51 1.00e-07 47.40
Created Date 25-Jun-2017

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