iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-054890

UUCD1 version

UUC-MaM-00364

Ensembl Protein ID

ENSMMUP00000000410.2

UniProt Accession

F6YVE7; F6YVE7_MACMU

Genbank Protein ID

AFH29827.1; AFH29828.1; EHH27892.1

Protein Name

Putative uncharacterized protein; Suppressor of cytokine signaling 4

Genbank Nucleotide ID

JSUE03039749; JU473024; CM001259

Gene Name

SOCS4; EGK_18204

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000000304.3	ENSMMUT00000000443.3	ENSMMUP00000000410.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	2.50e-16	60.4	378	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   ++LP+P+s+k YL++++y+
   Q: 378  STPLIRTFPFSLQHICRTVICNCTTYDGI---NALPIPSSMKLYLKEYHYK 425
           678899***********************...****************985 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAENNENNSK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV 60
SLRNRERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCTCCGC GTGGAAATTA GCCGGTTGCC CGGGCAAGTG AGGGAGGAAG GGAGGGAGCT 60
GAACACGGAA GTGGTGGCGG CGCCCAGGGA ACCGGCGGAG GCGTAGACCG TGACGGCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

mcc:696146

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	92.69	0.00e+00	785.00
IUUC-Apl-003839	Anas platyrhynchos	79.27	0.00e+00	639.00
IUUC-Aca-004840	Anolis carolinensis	80.18	0.00e+00	702.00
IUUC-Bta-012503	Bos taurus	92.05	0.00e+00	780.00
IUUC-Bol-016597	Brassica oleracea	30.38	7.60e-02	32.30
IUUC-Cja-019284	Callithrix jacchus	96.82	0.00e+00	816.00
IUUC-Cfa-020890	Canis familiaris	92.95	0.00e+00	794.00
IUUC-Cpo-022081	Cavia porcellus	77.93	0.00e+00	670.00
IUUC-Csa-023076	Chlorocebus sabaeus	99.77	0.00e+00	844.00
IUUC-Cho-024700	Choloepus hoffmanni	92.97	0.00e+00	825.00
IUUC-Dno-029961	Dasypus novemcinctus	93.42	0.00e+00	823.00
IUUC-Dor-030273	Dipodomys ordii	92.29	0.00e+00	791.00
IUUC-Ete-032972	Echinops telfairi	91.67	1.00e-167	582.00
IUUC-Eca-034289	Equus caballus	93.42	0.00e+00	790.00
IUUC-Eeu-035208	Erinaceus europaeus	89.86	0.00e+00	742.00
IUUC-Fal-036829	Ficedula albicollis	79.27	0.00e+00	634.00
IUUC-Gga-040725	Gallus gallus	78.82	0.00e+00	665.00
IUUC-Ggo-044886	Gorilla gorilla	98.86	0.00e+00	835.00
IUUC-Hsa-046322	Homo sapiens	98.64	0.00e+00	833.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	93.10	0.00e+00	786.00
IUUC-Lch-049459	Latimeria chalumnae	57.53	5.00e-138	484.00
IUUC-Laf-053484	Loxodonta africana	94.48	0.00e+00	788.00
IUUC-Meu-056532	Macropus eugenii	85.13	0.00e+00	642.00
IUUC-Mtr-057670	Medicago truncatula	36.67	1.90e+00	26.90
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.40e-02	33.10
IUUC-Mmr-061714	Microcebus murinus	95.46	0.00e+00	800.00
IUUC-Mmu-063161	Mus musculus	86.64	0.00e+00	733.00
IUUC-Mac-064598	Musa acuminata	25.00	8.20e-01	26.90
IUUC-Mpu-066499	Mustela putorius furo	92.95	0.00e+00	811.00
IUUC-Mlu-066945	Myotis lucifugus	92.29	0.00e+00	777.00
IUUC-Nle-069976	Nomascus leucogenys	98.41	0.00e+00	830.00
IUUC-Opr-070255	Ochotona princeps	87.05	0.00e+00	750.00
IUUC-Ocu-074764	Oryctolagus cuniculus	92.29	0.00e+00	782.00
IUUC-Oga-088910	Otolemur garnettii	88.01	0.00e+00	766.00
IUUC-Oar-090330	Ovis aries	92.05	0.00e+00	777.00
IUUC-Ptr-090709	Pan troglodytes	98.86	0.00e+00	835.00
IUUC-Pan-092540	Papio anubis	99.77	0.00e+00	844.00
IUUC-Psi-093678	Pelodiscus sinensis	81.09	0.00e+00	718.00
IUUC-Pfo-097139	Poecilia formosa	81.40	1.00e-87	317.00
IUUC-Pab-097970	Pongo abelii	97.86	0.00e+00	691.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.20e-01	31.20
IUUC-Pca-100211	Procavia capensis	82.09	0.00e+00	662.00
IUUC-Rno-106014	Rattus norvegicus	84.79	0.00e+00	727.00
IUUC-Sha-106822	Sarcophilus harrisii	84.56	0.00e+00	719.00
IUUC-Ssc-115821	Sus scrofa	93.20	0.00e+00	788.00
IUUC-Tgu-117117	Taeniopygia guttata	79.73	0.00e+00	637.00
IUUC-Tsy-118979	Tarsius syrichta	96.62	1.00e-127	448.00
IUUC-Tca-121131	Theobroma cacao	30.77	3.00e-03	36.20
IUUC-Vpa-130626	Vicugna pacos	92.29	0.00e+00	782.00
IUUC-Vvi-131327	Vitis vinifera	43.75	9.70e-02	31.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence