iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000180901.10	ENST00000375286.7	ENSP00000364435.3
ENSG00000180901.10	ENST00000322444.6	ENSP00000312814.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.20e-07	33.6	73	142

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 2    DvilvvggeeffahkivLaas.SsvFyalf...lmele.esksklmveikdvqpevfrallkFlYtgklde 67
           +v l+vgg++f +++ +L +   s++ +l+   + el+ ++++++ + i+ ++p++f  +l++l++gkl +
   Q: 73   WVRLNVGGTYFVTTRQTLGREpKSFLCRLCcqeDPELDsDKDETGAYLID-RDPTYFGPILNYLRHGKLII 142
           89****************************8777778888899*******.*****************976 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MAELQLDPAM AGLGGGGGSG VGDGGGPVRG PPSPRPAGPT PRGHGRPAAA VAQPLEPGPG 60
PPERAGGGGA ARWVRLNVGG TYFVTTRQTL GREPKSFLCR LCCQEDPELD SDKDETGAYL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGTGGTTT TGCCTTCGAG GAGGGGTGCC CAGTGGTGAT GCCCAGGAGA GGGAATGGAA 60
ACCTGGAGCT GGGAGTGAGG TTAGAGCTGT AAGATCCAAG ACCCAGGGAG ACAAGAGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB

Pfam

PF02214--BTB_2

SMART

SM00225--BTB

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0032403--F:protein complex binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization

KEGG

hsa:23510

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002150	Ailuropoda melanoleuca	97.47	5.00e-104	370.00
IUUC-Aca-004919	Anolis carolinensis	95.83	3.00e-100	357.00
IUUC-Ame-010631	Astyanax mexicanus	95.31	3.00e-106	377.00
IUUC-Bta-012519	Bos taurus	100.00	9.00e-105	372.00
IUUC-Cel-018133	Caenorhabditis elegans	56.41	1.00e-59	223.00
IUUC-Cja-018861	Callithrix jacchus	99.56	7.00e-114	402.00
IUUC-Cfa-020326	Canis familiaris	100.00	1.00e-104	372.00
IUUC-Csa-023830	Chlorocebus sabaeus	100.00	7.00e-109	386.00
IUUC-Dre-028635	Danio rerio	94.33	4.00e-106	377.00
IUUC-Ete-032244	Echinops telfairi	98.43	2.00e-103	368.00
IUUC-Fca-035620	Felis catus	100.00	7.00e-101	359.00
IUUC-Fal-037159	Ficedula albicollis	95.85	2.00e-100	358.00
IUUC-Gmo-039668	Gadus morhua	92.75	2.00e-104	371.00
IUUC-Gga-041005	Gallus gallus	95.34	1.00e-100	359.00
IUUC-Gac-041655	Gasterosteus aculeatus	93.30	4.00e-105	373.00
IUUC-Ggo-045116	Gorilla gorilla	100.00	7.00e-109	386.00
IUUC-Itr-048962	Ictidomys tridecemlineatus	99.45	9.00e-100	355.00
IUUC-Lch-049898	Latimeria chalumnae	94.33	5.00e-106	377.00
IUUC-Loc-052098	Lepisosteus oculatus	94.85	3.00e-107	380.00
IUUC-Mcc-055741	Macaca mulatta	100.00	2.00e-103	368.00
IUUC-Mga-059928	Meleagris gallopavo	89.53	2.00e-79	287.00
IUUC-Mmr-060698	Microcebus murinus	99.09	2.00e-108	385.00
IUUC-Mdo-062332	Monodelphis domestica	78.20	1.00e-102	365.00
IUUC-Mmu-063971	Mus musculus	99.46	3.00e-100	358.00
IUUC-Mpu-065821	Mustela putorius furo	100.00	1.00e-104	372.00
IUUC-Mlu-066986	Myotis lucifugus	91.63	1.00e-109	389.00
IUUC-Nle-070119	Nomascus leucogenys	91.19	2.00e-105	374.00
IUUC-Opr-070784	Ochotona princeps	100.00	5.00e-98	350.00
IUUC-Ont-072163	Oreochromis niloticus	92.78	2.00e-105	375.00
IUUC-Oga-088096	Otolemur garnettii	99.55	2.00e-108	385.00
IUUC-Oar-089656	Ovis aries	97.96	5.00e-104	369.00
IUUC-Ptr-090889	Pan troglodytes	99.62	2.00e-111	395.00
IUUC-Pan-092106	Papio anubis	100.00	7.00e-109	386.00
IUUC-Psi-093476	Pelodiscus sinensis	93.88	4.00e-101	360.00
IUUC-Pfo-097244	Poecilia formosa	93.30	1.00e-105	375.00
IUUC-Pva-102304	Pteropus vampyrus	99.48	4.00e-104	370.00
IUUC-Rno-105495	Rattus norvegicus	98.24	1.00e-111	395.00
IUUC-Sha-107047	Sarcophilus harrisii	97.38	4.00e-101	360.00
IUUC-Sly-111306	Solanum lycopersicum	43.48	6.00e-12	65.50
IUUC-Stu-112163	Solanum tuberosum	43.48	8.00e-12	64.70
IUUC-Tru-117728	Takifugu rubripes	93.30	1.00e-105	375.00
IUUC-Tsy-119068	Tarsius syrichta	99.33	4.00e-76	276.00
IUUC-Tni-120303	Tetraodon nigroviridis	93.30	9.00e-106	376.00
IUUC-Tbe-128028	Tupaia belangeri	96.36	2.00e-102	364.00
IUUC-Vpa-130627	Vicugna pacos	96.67	1.00e-76	278.00
IUUC-Xtr-132932	Xenopus tropicalis	82.65	2.00e-99	355.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence