iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033580

UUCD1 version

UUC-EqC-00136

Ensembl Protein ID

ENSECAP00000010176.1

UniProt Accession

F6RXW1; F6RXW1_HORSE

Protein Name

Uncharacterized protein

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011935.1	ENSECAT00000012875.1	ENSECAP00000010176.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.40e-130	435.0	400	732

Active Site

Position(s)	Description	Evidence
701	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 400  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 487
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+eNk+eYv+l+v+
   Q: 488  GFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVN 572
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k +t+ k+ +t+ds++++wFw+++e f++e r+++LqFv
   Q: 573  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVNTRLKH-CTPDSNVVKWFWKAVEFFDEERRARLLQFV 660
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ da +++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 661  TGSSRVPLQGFKALQgaagPRLFTIHQiDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 732
           **********************************************************************76 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

LTVLCAKNLV KKDFFRLPDP FAKVVVDGSG QCHSTDTVKN TLDPKWNQHY DLYIGKSDSV 60
TISVWNHKKI HKKQGAGFLG CVRLLSNAIN RLKDTGYQRL DLCKLGPNDN DTVRGQIVVS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTACAGTA CTCTGTGCAA AAAACTTGGT GAAAAAGGAT TTTTTCCGTA AGTAAATTGA 60
CTTTAAATCT TGTATGTTGT GTGTAGGTTT TTTTAGATAG CATTTTCAGA ATTGTCTAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	99.59	0.00e+00	1503.00
IUUC-Apl-003513	Anas platyrhynchos	97.68	0.00e+00	1480.00
IUUC-Aca-005358	Anolis carolinensis	97.29	0.00e+00	1474.00
IUUC-Ame-011320	Astyanax mexicanus	88.02	0.00e+00	1363.00
IUUC-Bta-013399	Bos taurus	99.73	0.00e+00	1493.00
IUUC-Cja-019355	Callithrix jacchus	99.59	0.00e+00	1502.00
IUUC-Cpo-022200	Cavia porcellus	99.73	0.00e+00	1502.00
IUUC-Cin-025126	Ciona intestinalis	66.67	0.00e+00	968.00
IUUC-Csv-026339	Ciona savignyi	64.89	0.00e+00	1000.00
IUUC-Dre-027650	Danio rerio	90.40	0.00e+00	1410.00
IUUC-Dno-029534	Dasypus novemcinctus	99.73	0.00e+00	1504.00
IUUC-Ete-032715	Echinops telfairi	94.93	0.00e+00	1410.00
IUUC-Eeu-034945	Erinaceus europaeus	97.85	0.00e+00	1394.00
IUUC-Fal-037275	Ficedula albicollis	97.43	0.00e+00	1470.00
IUUC-Gga-041060	Gallus gallus	94.44	0.00e+00	1408.00
IUUC-Gac-041295	Gasterosteus aculeatus	91.89	0.00e+00	1399.00
IUUC-Hsa-046726	Homo sapiens	99.73	0.00e+00	1504.00
IUUC-Lch-050026	Latimeria chalumnae	95.53	0.00e+00	1443.00
IUUC-Loc-051760	Lepisosteus oculatus	89.02	0.00e+00	1379.00
IUUC-Laf-053753	Loxodonta africana	99.86	0.00e+00	1503.00
IUUC-Mcc-054815	Macaca mulatta	99.45	0.00e+00	1497.00
IUUC-Meu-056436	Macropus eugenii	75.65	0.00e+00	1073.00
IUUC-Mpo-057442	Magnaporthe poae	38.43	4.00e-146	512.00
IUUC-Mmr-060806	Microcebus murinus	99.73	0.00e+00	1503.00
IUUC-Mdo-062805	Monodelphis domestica	97.41	0.00e+00	1464.00
IUUC-Mmu-064034	Mus musculus	99.45	0.00e+00	1496.00
IUUC-Mpu-066762	Mustela putorius furo	99.59	0.00e+00	1501.00
IUUC-Mlu-066981	Myotis lucifugus	99.86	0.00e+00	1502.00
IUUC-Nle-069804	Nomascus leucogenys	99.73	0.00e+00	1503.00
IUUC-Opr-070591	Ochotona princeps	94.25	0.00e+00	1398.00
IUUC-Ont-071239	Oreochromis niloticus	92.83	0.00e+00	1406.00
IUUC-Oan-072699	Ornithorhynchus anatinus	95.63	0.00e+00	1469.00
IUUC-Ocu-074913	Oryctolagus cuniculus	100.00	0.00e+00	1506.00
IUUC-Ola-086597	Oryzias latipes	85.62	0.00e+00	1286.00
IUUC-Oga-089116	Otolemur garnettii	96.17	0.00e+00	1436.00
IUUC-Oar-089366	Ovis aries	99.45	0.00e+00	1494.00
IUUC-Ptr-091382	Pan troglodytes	99.73	0.00e+00	1504.00
IUUC-Psi-093298	Pelodiscus sinensis	97.96	0.00e+00	1459.00
IUUC-Pma-094354	Petromyzon marinus	73.77	0.00e+00	1109.00
IUUC-Pfo-096071	Poecilia formosa	90.34	0.00e+00	1397.00
IUUC-Pab-098682	Pongo abelii	99.73	0.00e+00	1504.00
IUUC-Pca-100516	Procavia capensis	90.41	0.00e+00	639.00
IUUC-Pva-102754	Pteropus vampyrus	98.77	0.00e+00	1466.00
IUUC-Rno-105600	Rattus norvegicus	99.37	0.00e+00	1295.00
IUUC-Sha-107144	Sarcophilus harrisii	97.36	0.00e+00	1358.00
IUUC-Spo-108171	Schizosaccharomyces pombe	40.50	1.00e-162	566.00
IUUC-Sar-113122	Sorex araneus	88.63	0.00e+00	1285.00
IUUC-Tgu-117112	Taeniopygia guttata	97.15	0.00e+00	1469.00
IUUC-Tru-118497	Takifugu rubripes	89.17	0.00e+00	1345.00
IUUC-Tsy-118819	Tarsius syrichta	99.22	0.00e+00	1041.00
IUUC-Tni-120781	Tetraodon nigroviridis	89.61	0.00e+00	1180.00
IUUC-Tme-126897	Tuber melanosporum	39.42	4.00e-152	531.00
IUUC-Tbe-127371	Tupaia belangeri	89.78	0.00e+00	1202.00
IUUC-Ttr-129305	Tursiops truncatus	91.82	0.00e+00	1288.00
IUUC-Vpa-130591	Vicugna pacos	89.45	0.00e+00	1303.00
IUUC-Xtr-132979	Xenopus tropicalis	77.13	0.00e+00	1106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence