iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035617

Ensembl Protein ID

ENSFCAP00000021202.1

UniProt Accession

M3X3K2; M3X3K2_FELCA

Genbank Protein ID

ENSFCAP00000021202

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02193814

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000022001.1	ENSFCAT00000024257.1	ENSFCAP00000021202.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-118	394.7	315	644

Active Site

Position(s)	Description	Evidence
615	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 315  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 400
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 401  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 486
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ ++t+y++gy++++p+iqwFwev+e+++ eer  +LqFvT
   Q: 487  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIRNTEYTSGYEREDPVIQWFWEVVEDITPEERVLLLQFVT 575
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 576  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 644
           ******************8888888868888********************************986555 PP

Organism

Felis catus

Protein Sequence
(Fasta)

MTQNEDLREN MLRQVLEHLS QQSESQYLKI LTSLAEVATT NGHKLLSLSS NYDAQMKSLL 60
RIVRIFCHVF RIGPSSPSNG IDLGYNGNKT PRSQVFKPLE LLWHSLDEWL VLIATELMKN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACACAGA ATGAAGATCT CCGAGAAAAC ATGGTAATTG TGCTAATAGC TTGTAAAAGA 60
ATAAGCCTTA TTCATGCTTA TCATATATGG CATTTTAGAA TGTGCTTGGT AGTTTTATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	99.69	0.00e+00	1350.00
IUUC-Apl-003400	Anas platyrhynchos	87.87	0.00e+00	1150.00
IUUC-Aca-005375	Anolis carolinensis	89.21	0.00e+00	1209.00
IUUC-Ame-011847	Astyanax mexicanus	81.18	0.00e+00	1126.00
IUUC-Bta-012831	Bos taurus	99.23	0.00e+00	1351.00
IUUC-Cja-019160	Callithrix jacchus	98.46	0.00e+00	1337.00
IUUC-Cfa-020346	Canis familiaris	99.69	0.00e+00	1355.00
IUUC-Cpo-021766	Cavia porcellus	97.22	0.00e+00	1323.00
IUUC-Csa-023768	Chlorocebus sabaeus	97.99	0.00e+00	1337.00
IUUC-Cho-024688	Choloepus hoffmanni	94.19	0.00e+00	1177.00
IUUC-Cin-025417	Ciona intestinalis	50.63	2.00e-138	486.00
IUUC-Csv-025993	Ciona savignyi	44.72	7.00e-136	478.00
IUUC-Dre-027819	Danio rerio	82.57	0.00e+00	1114.00
IUUC-Dno-029027	Dasypus novemcinctus	96.79	0.00e+00	1309.00
IUUC-Dor-030327	Dipodomys ordii	93.98	0.00e+00	1255.00
IUUC-Ete-032966	Echinops telfairi	96.46	0.00e+00	1311.00
IUUC-Eca-034339	Equus caballus	98.77	0.00e+00	1344.00
IUUC-Eeu-034544	Erinaceus europaeus	82.02	9.00e-149	521.00
IUUC-Fal-036687	Ficedula albicollis	88.11	0.00e+00	1221.00
IUUC-Gmo-039508	Gadus morhua	87.70	0.00e+00	826.00
IUUC-Gga-040845	Gallus gallus	88.69	0.00e+00	1245.00
IUUC-Gac-041894	Gasterosteus aculeatus	82.32	0.00e+00	1103.00
IUUC-Ggo-044465	Gorilla gorilla	98.00	0.00e+00	1333.00
IUUC-Hsa-045731	Homo sapiens	98.30	0.00e+00	1340.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	98.46	0.00e+00	1334.00
IUUC-Lch-050436	Latimeria chalumnae	87.00	0.00e+00	1167.00
IUUC-Loc-052287	Lepisosteus oculatus	81.69	0.00e+00	1144.00
IUUC-Laf-053846	Loxodonta africana	98.31	0.00e+00	1331.00
IUUC-Mcc-055845	Macaca mulatta	98.15	0.00e+00	1338.00
IUUC-Meu-056060	Macropus eugenii	65.12	4.00e-139	488.00
IUUC-Mga-059935	Meleagris gallopavo	92.91	0.00e+00	1252.00
IUUC-Mmr-060960	Microcebus murinus	99.07	0.00e+00	1347.00
IUUC-Mdo-061851	Monodelphis domestica	91.04	0.00e+00	1281.00
IUUC-Mmu-063657	Mus musculus	96.14	0.00e+00	1309.00
IUUC-Mpu-066161	Mustela putorius furo	100.00	0.00e+00	833.00
IUUC-Mlu-067354	Myotis lucifugus	98.31	0.00e+00	1309.00
IUUC-Nle-069112	Nomascus leucogenys	98.15	0.00e+00	1337.00
IUUC-Opr-070686	Ochotona princeps	89.07	0.00e+00	810.00
IUUC-Ont-072398	Oreochromis niloticus	82.24	0.00e+00	1111.00
IUUC-Oan-073194	Ornithorhynchus anatinus	93.84	0.00e+00	1270.00
IUUC-Ocu-074397	Oryctolagus cuniculus	80.86	0.00e+00	1033.00
IUUC-Ola-086777	Oryzias latipes	75.58	0.00e+00	1045.00
IUUC-Oga-088684	Otolemur garnettii	98.61	0.00e+00	1338.00
IUUC-Oar-089428	Ovis aries	98.11	0.00e+00	1304.00
IUUC-Ptr-090529	Pan troglodytes	98.15	0.00e+00	1338.00
IUUC-Pan-091702	Papio anubis	97.99	0.00e+00	1337.00
IUUC-Psi-093969	Pelodiscus sinensis	88.84	0.00e+00	1241.00
IUUC-Pfo-097364	Poecilia formosa	83.64	0.00e+00	1122.00
IUUC-Pab-098574	Pongo abelii	98.30	0.00e+00	1340.00
IUUC-Pca-100525	Procavia capensis	70.02	2.00e-168	586.00
IUUC-Pva-102365	Pteropus vampyrus	92.15	0.00e+00	1209.00
IUUC-Rno-105153	Rattus norvegicus	96.14	0.00e+00	1313.00
IUUC-Sha-107319	Sarcophilus harrisii	91.04	0.00e+00	1276.00
IUUC-Sar-113449	Sorex araneus	82.92	1.00e-180	627.00
IUUC-Ssc-115865	Sus scrofa	99.07	0.00e+00	1347.00
IUUC-Tgu-117225	Taeniopygia guttata	88.11	0.00e+00	1238.00
IUUC-Tru-118026	Takifugu rubripes	78.73	0.00e+00	1084.00
IUUC-Tsy-119407	Tarsius syrichta	90.74	0.00e+00	1208.00
IUUC-Tni-120234	Tetraodon nigroviridis	79.39	0.00e+00	787.00
IUUC-Tur-126774	Triticum urartu	29.17	5.00e-46	179.00
IUUC-Tbe-127708	Tupaia belangeri	96.64	1.00e-155	543.00
IUUC-Ttr-128667	Tursiops truncatus	98.92	0.00e+00	1347.00
IUUC-Vpa-130200	Vicugna pacos	99.07	0.00e+00	1347.00
IUUC-Xtr-132176	Xenopus tropicalis	84.04	0.00e+00	1175.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence