iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000019691.3	ENSMMUT00000072072.1	ENSMMUP00000052006.1
ENSMMUG00000019691.3	ENSMMUT00000073979.1	ENSMMUP00000044912.1
ENSMMUG00000019691.3	ENSMMUT00000068673.1	ENSMMUP00000043472.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-41	144.3	418	725

Active Site

Position(s)	Description	Evidence
696	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v E+   g +++G+++efl+ll+++l+n++  lf  + + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 418  YAIEVAYVIENdnfGSEHPGSKQEFLSLLMQHLENSS--LF--EGSLSKNLSLNSQAL-----KENLYYEAGKMLAISLVHGGPSPGFF 497
           56788898887777***********************..45..677788888888885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++++l+  +   e+++ + +++ ++ + +i  +   ++ ++ +dl++      ++e++++  + g+ +   t ++k++ vk+++ y
   Q: 498  SKTLFNCLVYGP---ENTQPILDDVSDFdVAQIIIRI--NTATTVADLKSV-----INECYNYLELIGCLRLITTLSDKYMLVKDILVY 576
           ***********8...*************988888774..556666788876.....8889999999*********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++++ e  +++l+++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + ++ ++  
   Q: 577  HVIQRVQAPFESFKQGLKTLGVLEKIQAYPEAFCSILCHKPESLSAKILSD--LFTVHTLPDVKAL-GFWNSYlQAVEDGKSTTTMEdi 662
           *************************************************99..888899******8.8998765788777777666666 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
             F+Tg+s++P++Gf++ + ++ +++      ++P  n+C n+L +P  +++++++e++ ++i++t  +
   Q: 663  liFATGCSSIPPAGFKPTP-SIECLPV-----DFPVGNKCNNCLAIPVTNTYKEFQENMDFTIRNTLKL 725
           66****************9.8899999.....********************************98665 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

ILIPALQTSD SESVDLEDDL EESACLTESK MNENKPGDSQ NLACVFCRKN DDCPNKYGEK 60
KTKEKWNLTV HYYCLLMSSG IWQRGKEEEG VYGFLIEDIR KEVNRASKLK CCVCKKNGAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATACTGATTC CTGCACTCCA GACGTCAGAT TCCGAATCAG TAGATCTGGA GGATGACCTT 60
GAGGAGTCTG CATGTTTAAC TGAAAGGTTA GAAAATTCTG TGAGTTTTAA AAACACTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	91.50	0.00e+00	1366.00
IUUC-Apl-003763	Anas platyrhynchos	60.03	0.00e+00	852.00
IUUC-Aca-004328	Anolis carolinensis	60.52	0.00e+00	865.00
IUUC-Ame-011288	Astyanax mexicanus	40.37	2.00e-162	566.00
IUUC-Bta-012496	Bos taurus	86.36	0.00e+00	1291.00
IUUC-Cja-019756	Callithrix jacchus	95.17	0.00e+00	1398.00
IUUC-Cfa-020806	Canis familiaris	89.53	0.00e+00	1347.00
IUUC-Cpo-022519	Cavia porcellus	86.12	0.00e+00	1268.00
IUUC-Csa-023957	Chlorocebus sabaeus	99.29	0.00e+00	1458.00
IUUC-Cho-024375	Choloepus hoffmanni	83.41	0.00e+00	1194.00
IUUC-Cin-025325	Ciona intestinalis	41.22	3.00e-66	245.00
IUUC-Csv-026262	Ciona savignyi	43.01	1.00e-67	250.00
IUUC-Dre-027829	Danio rerio	40.20	5.00e-153	535.00
IUUC-Dno-029362	Dasypus novemcinctus	89.42	0.00e+00	1323.00
IUUC-Dor-030710	Dipodomys ordii	83.71	0.00e+00	1261.00
IUUC-Dse-031248	Dothistroma septosporum	40.38	3.00e-03	37.70
IUUC-Dme-031692	Drosophila melanogaster	34.83	1.00e-42	167.00
IUUC-Ete-032282	Echinops telfairi	80.28	0.00e+00	1160.00
IUUC-Eca-033963	Equus caballus	89.38	0.00e+00	1351.00
IUUC-Eeu-035029	Erinaceus europaeus	85.96	0.00e+00	1290.00
IUUC-Fca-036229	Felis catus	90.65	0.00e+00	1367.00
IUUC-Fal-037015	Ficedula albicollis	58.48	0.00e+00	870.00
IUUC-Gmo-039715	Gadus morhua	39.25	5.00e-76	278.00
IUUC-Gga-040298	Gallus gallus	58.61	0.00e+00	907.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.34	3.00e-142	498.00
IUUC-Ggo-045456	Gorilla gorilla	97.59	0.00e+00	1438.00
IUUC-Hsa-046297	Homo sapiens	97.15	0.00e+00	1489.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	88.47	0.00e+00	934.00
IUUC-Lch-050287	Latimeria chalumnae	67.06	4.00e-105	375.00
IUUC-Loc-052839	Lepisosteus oculatus	55.05	8.00e-32	128.00
IUUC-Laf-053581	Loxodonta africana	88.29	0.00e+00	1305.00
IUUC-Meu-056753	Macropus eugenii	49.29	7.00e-129	454.00
IUUC-Mga-059902	Meleagris gallopavo	58.82	0.00e+00	913.00
IUUC-Mmr-061522	Microcebus murinus	91.97	0.00e+00	1414.00
IUUC-Mdo-063022	Monodelphis domestica	66.32	0.00e+00	914.00
IUUC-Mmu-063609	Mus musculus	77.58	0.00e+00	1179.00
IUUC-Mpu-066656	Mustela putorius furo	90.10	0.00e+00	1359.00
IUUC-Mlu-067011	Myotis lucifugus	87.98	0.00e+00	1315.00
IUUC-Nle-069949	Nomascus leucogenys	97.73	0.00e+00	1441.00
IUUC-Opr-071224	Ochotona princeps	84.21	1.00e-133	470.00
IUUC-Ont-072174	Oreochromis niloticus	37.64	7.00e-137	481.00
IUUC-Oan-072712	Ornithorhynchus anatinus	68.29	0.00e+00	981.00
IUUC-Ocu-073776	Oryctolagus cuniculus	91.22	0.00e+00	1356.00
IUUC-Ola-087247	Oryzias latipes	36.97	4.00e-129	455.00
IUUC-Oga-088094	Otolemur garnettii	88.64	0.00e+00	1242.00
IUUC-Oar-090248	Ovis aries	86.38	0.00e+00	1286.00
IUUC-Ptr-090634	Pan troglodytes	97.88	0.00e+00	1444.00
IUUC-Pan-092876	Papio anubis	99.58	0.00e+00	1464.00
IUUC-Psi-093580	Pelodiscus sinensis	61.41	0.00e+00	885.00
IUUC-Pma-094295	Petromyzon marinus	53.17	1.00e-72	266.00
IUUC-Pfo-096351	Poecilia formosa	36.86	2.00e-142	499.00
IUUC-Pab-097596	Pongo abelii	98.02	0.00e+00	1446.00
IUUC-Pca-100309	Procavia capensis	82.01	0.00e+00	1219.00
IUUC-Pva-102526	Pteropus vampyrus	91.78	0.00e+00	857.00
IUUC-Rno-105432	Rattus norvegicus	82.81	0.00e+00	1235.00
IUUC-Sha-107089	Sarcophilus harrisii	65.37	0.00e+00	1013.00
IUUC-Sar-113667	Sorex araneus	68.47	0.00e+00	974.00
IUUC-Ssc-116200	Sus scrofa	89.66	0.00e+00	1343.00
IUUC-Tgu-116467	Taeniopygia guttata	57.69	0.00e+00	853.00
IUUC-Tru-117690	Takifugu rubripes	38.12	9.00e-152	530.00
IUUC-Tsy-119481	Tarsius syrichta	88.00	0.00e+00	923.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.15	5.00e-134	471.00
IUUC-Tbe-127241	Tupaia belangeri	82.67	0.00e+00	1174.00
IUUC-Ttr-129057	Tursiops truncatus	81.02	0.00e+00	1160.00
IUUC-Vpa-130685	Vicugna pacos	87.34	0.00e+00	1268.00
IUUC-Xtr-132555	Xenopus tropicalis	53.25	0.00e+00	754.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence