iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.20e-41	141.3	387	691

Active Site

Position(s)	Description	Evidence
665	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvg...EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           +++ev +v+   E g +++G+++efl+ l+++l+n++    +++ +  ++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 387  YSIEVVYVNdndEVGSKHPGSKQEFLSHLMHHLENSS----VFEGSLAKNLSLNSQAV-----KENLYYEAGKMLAISLVHGGPSPGFF 466
           56777777767699***********************....46788888888999885.....689*********************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           s++++k+l   +   + l+++d+     + +i  +    i++ ++dl++   +++++e++++   +g+ + + t ++k++ vk+++ y 
   Q: 467  SETLFKCLAYGP--ENALPTLDDVSDLDVAQIIIK----IDT-AADLNIL--KSVINEYYNYLEFSGCLRLMTTLSDKYMLVKDILFYQ 546
           *********997..233444444333335555544....333.3566655..5569999999999************************ PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq... 266
           + +++k  +e+f++G++++  le+++++ e   ++l+++ e++++++l++  +   +  +d ++  +Fw+ + +++++ + ++ L+   
   Q: 547  VIKRVKAPFESFKQGLKTLGVLEKIQAYPEAFYNILCHKPESLSAKNLSDLFTI--HKLPDVKT-SRFWNSYlQAVEDGKSATTLEdil 632
           *************************************************96655..34566666.688887656676666655544444 PP
   S: 267  .FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet 330
            F+Tg+s++P+ Gf++ + ++ +++      ++P +n+C n+L LP  +++e+++e++ +Ai+ +
   Q: 633  hFATGCSSVPPTGFKPAP-SIECLHG-----DFPVANKCNNCLALPVTNTYEEFQENMDFAIRDS 691
           4****************9.8899988.....*******************************975 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MNENKPGNSQ SLACVFCRKN DDCPNKYGEK KTCEKWNFSV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVNRASKLK CTVCKKNGAS IGCVVPQCKR SYHLPCGLQK ECIFQFTDNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTAACGCAT CGACCCTGGG ACTTATACTC CGCGCCTGGT GAGGACGTGT CCCGGAGGGA 60
CTGAGGGTCA CGGGCGGCCG GGTAGGTGTG AGCGGTGGGC GCTTCTCCTT GCGCTGGACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

rno:299002

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	81.53	0.00e+00	1223.00
IUUC-Apl-003763	Anas platyrhynchos	56.88	0.00e+00	804.00
IUUC-Aca-004328	Anolis carolinensis	57.89	0.00e+00	828.00
IUUC-Ame-011288	Astyanax mexicanus	41.42	6.00e-161	561.00
IUUC-Bta-012496	Bos taurus	78.98	0.00e+00	1186.00
IUUC-Cja-019756	Callithrix jacchus	81.25	0.00e+00	1216.00
IUUC-Cfa-020806	Canis familiaris	80.20	0.00e+00	1207.00
IUUC-Cpo-022519	Cavia porcellus	78.77	0.00e+00	1162.00
IUUC-Csa-023957	Chlorocebus sabaeus	82.95	0.00e+00	1236.00
IUUC-Cho-024375	Choloepus hoffmanni	74.60	0.00e+00	1060.00
IUUC-Cin-025325	Ciona intestinalis	42.91	1.00e-68	253.00
IUUC-Csv-026262	Ciona savignyi	43.69	8.00e-68	250.00
IUUC-Dre-027829	Danio rerio	40.88	1.00e-154	540.00
IUUC-Dno-029362	Dasypus novemcinctus	80.46	0.00e+00	1181.00
IUUC-Dor-030710	Dipodomys ordii	78.52	0.00e+00	1183.00
IUUC-Dme-031692	Drosophila melanogaster	33.33	7.00e-42	165.00
IUUC-Ete-032282	Echinops telfairi	71.35	0.00e+00	1037.00
IUUC-Eca-033963	Equus caballus	80.82	0.00e+00	1221.00
IUUC-Eeu-035029	Erinaceus europaeus	77.98	0.00e+00	1177.00
IUUC-Fca-036229	Felis catus	80.40	0.00e+00	1216.00
IUUC-Fal-037015	Ficedula albicollis	56.05	0.00e+00	825.00
IUUC-Gmo-039715	Gadus morhua	39.67	6.00e-74	271.00
IUUC-Gga-040298	Gallus gallus	55.65	0.00e+00	853.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.52	8.00e-141	494.00
IUUC-Ggo-045456	Gorilla gorilla	81.82	0.00e+00	1221.00
IUUC-Hsa-046297	Homo sapiens	82.24	0.00e+00	1230.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	78.76	0.00e+00	828.00
IUUC-Lch-050287	Latimeria chalumnae	66.27	3.00e-104	372.00
IUUC-Loc-052839	Lepisosteus oculatus	55.96	1.00e-32	131.00
IUUC-Laf-053581	Loxodonta africana	79.94	0.00e+00	1194.00
IUUC-Mcc-055615	Macaca mulatta	82.81	0.00e+00	1234.00
IUUC-Meu-056753	Macropus eugenii	47.03	2.00e-118	419.00
IUUC-Mga-059902	Meleagris gallopavo	55.05	0.00e+00	853.00
IUUC-Mmr-061522	Microcebus murinus	82.53	0.00e+00	1227.00
IUUC-Mdo-063022	Monodelphis domestica	62.43	0.00e+00	846.00
IUUC-Mmu-063609	Mus musculus	87.97	0.00e+00	1351.00
IUUC-Mpu-066656	Mustela putorius furo	79.83	0.00e+00	1207.00
IUUC-Mlu-067011	Myotis lucifugus	80.06	0.00e+00	1181.00
IUUC-Nle-069949	Nomascus leucogenys	81.82	0.00e+00	1223.00
IUUC-Opr-071224	Ochotona princeps	77.48	2.00e-118	419.00
IUUC-Ont-072174	Oreochromis niloticus	36.47	4.00e-136	478.00
IUUC-Oan-072712	Ornithorhynchus anatinus	64.98	0.00e+00	915.00
IUUC-Ocu-073776	Oryctolagus cuniculus	81.37	0.00e+00	1210.00
IUUC-Ola-087247	Oryzias latipes	36.36	3.00e-129	456.00
IUUC-Oga-088094	Otolemur garnettii	79.18	0.00e+00	1107.00
IUUC-Oar-090248	Ovis aries	77.98	0.00e+00	1171.00
IUUC-Ptr-090634	Pan troglodytes	82.10	0.00e+00	1227.00
IUUC-Pan-092876	Papio anubis	82.67	0.00e+00	1233.00
IUUC-Psi-093580	Pelodiscus sinensis	59.46	0.00e+00	840.00
IUUC-Pma-094295	Petromyzon marinus	53.04	2.00e-71	261.00
IUUC-Pfo-096351	Poecilia formosa	36.94	8.00e-144	504.00
IUUC-Pab-097596	Pongo abelii	82.67	0.00e+00	1233.00
IUUC-Pca-100309	Procavia capensis	75.21	0.00e+00	1111.00
IUUC-Pva-102526	Pteropus vampyrus	82.88	0.00e+00	774.00
IUUC-Sha-107089	Sarcophilus harrisii	62.63	0.00e+00	955.00
IUUC-Sar-113667	Sorex araneus	61.51	0.00e+00	884.00
IUUC-Ssc-116200	Sus scrofa	80.23	0.00e+00	1198.00
IUUC-Tgu-116467	Taeniopygia guttata	55.36	0.00e+00	814.00
IUUC-Tru-117690	Takifugu rubripes	38.14	7.00e-149	521.00
IUUC-Tsy-119481	Tarsius syrichta	78.60	0.00e+00	826.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.16	2.00e-131	462.00
IUUC-Tbe-127241	Tupaia belangeri	73.90	0.00e+00	1058.00
IUUC-Ttr-129057	Tursiops truncatus	72.30	0.00e+00	1031.00
IUUC-Vpa-130685	Vicugna pacos	78.95	0.00e+00	1140.00
IUUC-Xtr-132555	Xenopus tropicalis	53.03	0.00e+00	746.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence