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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063955
Ensembl Protein ID ENSMUSP00000105486.1
UniProt Accession Q05BC3; Q05AF8; Q0P5V3; EMAL1_MOUSE
Genbank Protein ID AAH53094.2; AAH59839.1; AAH79582.1; AAI25290.1
Protein Name Echinoderm microtubule-associated protein-like 1
Genbank Nucleotide ID BC053094; BC059839; BC079582; BC125289
Gene Name Eml1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000058070.14 ENSMUST00000109857.7 ENSMUSP00000105483.1
ENSMUSG00000058070.14 ENSMUST00000109860.7 ENSMUSP00000105486.1
ENSMUSG00000058070.14 ENSMUST00000130999.1 ENSMUSP00000118325.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.10e-18 66.3 326 358
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 5    svtclaf...sd.tllvs..GsdDgtikvWDlr 31
            vtc+af   ++ ++l++   s+D+++ vWD+ 
   Q: 326  AVTCIAFsksNGgGHLCAvdDSNDHVLSVWDWQ 358
           59*******7669999887899*********85 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
 Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se.
Protein Sequence
(Fasta)
MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVSDRIAS LEQRVQMQED DIQLLKSALA 60
DVVRRLNITE EQQAVLNRKG PTKARPLGQT LPLRTTVNNG TVLPKKPSAS LPAPSGARKE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063955|E3,WD_repeat|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGTGGGACT AGACACCAGG AGAGAGGAAA AGGCATTCCA TAGTCTCCAG AGCTGGGTTT 60
CCAGAGACTG GTCCAGCACC CAGGGGTGCA GTAGCTTCTC GGGCAACATT CTGGGGCTGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063955|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03451--HELP
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005874--C:microtubule
GO:0048471--C:perinuclear region of cytoplasm
GO:0008017--F:microtubule binding
GO:0015631--F:tubulin binding
GO:0007420--P:brain development
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0000226--P:microtubule cytoskeleton organization
GO:0007052--P:mitotic spindle organization
GO:0007405--P:neuroblast proliferation
KEGG mmu:68519
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002077 Ailuropoda melanoleuca 91.18 0.00e+00 1469.00
IUUC-Apl-004179 Anas platyrhynchos 92.31 0.00e+00 1446.00
IUUC-Aca-004993 Anolis carolinensis 85.63 0.00e+00 1377.00
IUUC-Ame-011332 Astyanax mexicanus 76.82 0.00e+00 1298.00
IUUC-Bta-013419 Bos taurus 78.60 0.00e+00 1216.00
IUUC-Cel-018623 Caenorhabditis elegans 29.02 5.00e-82 299.00
IUUC-Cja-018976 Callithrix jacchus 93.72 0.00e+00 1494.00
IUUC-Cfa-021276 Canis familiaris 93.51 0.00e+00 1472.00
IUUC-Csa-023355 Chlorocebus sabaeus 94.02 0.00e+00 1481.00
IUUC-Dre-028728 Danio rerio 77.55 0.00e+00 1287.00
IUUC-Dno-029055 Dasypus novemcinctus 89.90 0.00e+00 1481.00
IUUC-Dor-030628 Dipodomys ordii 93.65 0.00e+00 1476.00
IUUC-Dme-032093 Drosophila melanogaster 37.48 3.00e-120 426.00
IUUC-Ete-032845 Echinops telfairi 94.53 0.00e+00 812.00
IUUC-Eca-034266 Equus caballus 94.89 0.00e+00 1541.00
IUUC-Fca-035446 Felis catus 94.27 0.00e+00 1459.00
IUUC-Fal-036734 Ficedula albicollis 88.82 0.00e+00 1445.00
IUUC-Gmo-038689 Gadus morhua 73.63 0.00e+00 1256.00
IUUC-Gga-040934 Gallus gallus 92.70 0.00e+00 1122.00
IUUC-Gac-042476 Gasterosteus aculeatus 73.42 0.00e+00 1255.00
IUUC-Ggo-044828 Gorilla gorilla 93.50 0.00e+00 1529.00
IUUC-Hsa-045664 Homo sapiens 93.88 0.00e+00 1545.00
IUUC-Lch-050508 Latimeria chalumnae 83.57 0.00e+00 1387.00
IUUC-Loc-052823 Lepisosteus oculatus 81.55 0.00e+00 1335.00
IUUC-Laf-054164 Loxodonta africana 89.05 0.00e+00 1379.00
IUUC-Mcc-055810 Macaca mulatta 91.73 0.00e+00 1468.00
IUUC-Mga-059405 Meleagris gallopavo 88.93 0.00e+00 1428.00
IUUC-Mmr-061144 Microcebus murinus 94.38 0.00e+00 1484.00
IUUC-Mdo-062834 Monodelphis domestica 89.83 0.00e+00 1466.00
IUUC-Mpu-066240 Mustela putorius furo 93.89 0.00e+00 1446.00
IUUC-Mlu-067847 Myotis lucifugus 92.57 0.00e+00 1076.00
IUUC-Nle-069783 Nomascus leucogenys 92.99 0.00e+00 1502.00
IUUC-Opr-070409 Ochotona princeps 85.84 0.00e+00 1335.00
IUUC-Ont-072468 Oreochromis niloticus 77.33 0.00e+00 1289.00
IUUC-Oan-073315 Ornithorhynchus anatinus 90.62 0.00e+00 1429.00
IUUC-Ocu-074604 Oryctolagus cuniculus 93.63 0.00e+00 1229.00
IUUC-Ola-086734 Oryzias latipes 75.18 0.00e+00 1252.00
IUUC-Oga-089105 Otolemur garnettii 92.93 0.00e+00 1492.00
IUUC-Oar-090057 Ovis aries 94.58 0.00e+00 1504.00
IUUC-Ptr-091138 Pan troglodytes 93.88 0.00e+00 1546.00
IUUC-Pan-092691 Papio anubis 86.99 0.00e+00 1366.00
IUUC-Psi-093076 Pelodiscus sinensis 89.51 0.00e+00 1443.00
IUUC-Pma-094555 Petromyzon marinus 57.66 0.00e+00 830.00
IUUC-Pfo-096794 Poecilia formosa 73.76 0.00e+00 1214.00
IUUC-Pab-097787 Pongo abelii 91.36 0.00e+00 1499.00
IUUC-Pva-102676 Pteropus vampyrus 92.00 0.00e+00 1444.00
IUUC-Rno-105971 Rattus norvegicus 88.26 0.00e+00 1321.00
IUUC-Sha-107530 Sarcophilus harrisii 91.50 0.00e+00 1442.00
IUUC-Ssc-116169 Sus scrofa 79.70 0.00e+00 998.00
IUUC-Tgu-117046 Taeniopygia guttata 91.85 0.00e+00 1422.00
IUUC-Tru-118596 Takifugu rubripes 72.59 0.00e+00 1223.00
IUUC-Tsy-119142 Tarsius syrichta 89.87 0.00e+00 1087.00
IUUC-Tni-120377 Tetraodon nigroviridis 76.38 0.00e+00 1268.00
IUUC-Tbe-127916 Tupaia belangeri 77.52 0.00e+00 977.00
IUUC-Ttr-129042 Tursiops truncatus 92.49 0.00e+00 1506.00
IUUC-Xtr-132117 Xenopus tropicalis 81.67 0.00e+00 1332.00
Created Date 25-Jun-2017

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