iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117474

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01017119

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000006360.1	ENSTGUT00000006655.1	ENSTGUP00000006589.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-134	447.0	574	903

Active Site

Position(s)	Description	Evidence
873	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld+++
   Q: 574  FLKARLWIEFDGEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFF 662
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f v+ee++g+t+++eLk+gG++i Vtn+Nk++Y++lv+++r
   Q: 663  IRPFYKMMLQKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIVDEELFGQTHQHELKSGGSEIVVTNKNKRDYIHLVIQWR 746
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + +++++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv d+k +tkyk+gy+ ++++iqwFw+++ +++se+r ++LqFvTg
   Q: 747  FVSRVQKQMTAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVADWKLHTKYKNGYNINHQVIQWFWKAVLMMDSEKRIRLLQFVTG 835
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p+lf++++++++++lP+++TCfn+L+LP+Y+s e l +kLl+Aie+t+gF+
   Q: 836  TSRVPMNGFAELYgsngPQLFTVEQWGTPEKLPRAHTCFNRLDLPPYDSFEDLWDKLLLAIENTQGFD 903
           *******************************************************************8 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

RRAAMAASPA EVLGLPGEEE NTRIVRVKVI AGIGLAKKDI LGASDPYVKV TLYDPVNGAL 60
TSIQTKTIRK SLNPKWNEEL LFRVNPQKHR LLFEVFDENR LTRDDFLGQV DIPLYQLPTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGTGCGG CCATGGCGGC GTCTCCTGCG GAGGTGCTCG GGCTGCCGGG CGAGGAGGTG 60
AGCGAGGCCC CGCGCCGCCC CGCTGCCCTC TCCGCGGAGC CGAGCGCGGG CTTCTCTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	80.22	0.00e+00	1318.00
IUUC-Apl-003886	Anas platyrhynchos	86.76	0.00e+00	1547.00
IUUC-Ame-011138	Astyanax mexicanus	84.13	0.00e+00	840.00
IUUC-Bgr-012148	Blumeria graminis	46.71	1.00e-152	533.00
IUUC-Bta-012453	Bos taurus	80.27	0.00e+00	1275.00
IUUC-Bci-013785	Botrytis cinerea	47.25	7.00e-155	540.00
IUUC-Cja-019034	Callithrix jacchus	82.02	0.00e+00	1223.00
IUUC-Cfa-020258	Canis familiaris	81.43	0.00e+00	1300.00
IUUC-Cpo-021648	Cavia porcellus	79.18	0.00e+00	1421.00
IUUC-Csa-023334	Chlorocebus sabaeus	82.28	0.00e+00	1462.00
IUUC-Cin-025157	Ciona intestinalis	56.46	0.00e+00	976.00
IUUC-Dre-027924	Danio rerio	68.22	0.00e+00	1028.00
IUUC-Dno-029159	Dasypus novemcinctus	79.02	0.00e+00	1165.00
IUUC-Ete-032409	Echinops telfairi	76.16	0.00e+00	1051.00
IUUC-Eca-033441	Equus caballus	81.57	0.00e+00	1435.00
IUUC-Eeu-034546	Erinaceus europaeus	70.98	0.00e+00	1041.00
IUUC-Fca-036384	Felis catus	81.71	0.00e+00	1328.00
IUUC-Fal-037547	Ficedula albicollis	97.52	0.00e+00	1665.00
IUUC-Gmo-039679	Gadus morhua	68.32	0.00e+00	1206.00
IUUC-Gga-040524	Gallus gallus	93.90	0.00e+00	1623.00
IUUC-Gac-042607	Gasterosteus aculeatus	66.91	0.00e+00	1211.00
IUUC-Hsa-046479	Homo sapiens	81.76	0.00e+00	1315.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	72.45	0.00e+00	1066.00
IUUC-Lch-050445	Latimeria chalumnae	73.70	0.00e+00	1178.00
IUUC-Loc-052645	Lepisosteus oculatus	75.03	0.00e+00	1335.00
IUUC-Laf-053638	Loxodonta africana	75.00	0.00e+00	1216.00
IUUC-Mcc-055585	Macaca mulatta	82.38	0.00e+00	1317.00
IUUC-Meu-056897	Macropus eugenii	92.68	3.00e-166	578.00
IUUC-Mga-059362	Meleagris gallopavo	86.63	0.00e+00	1567.00
IUUC-Mmr-061061	Microcebus murinus	82.51	0.00e+00	1359.00
IUUC-Mmu-063318	Mus musculus	73.73	0.00e+00	1288.00
IUUC-Mpu-066567	Mustela putorius furo	81.88	0.00e+00	1483.00
IUUC-Mlu-068148	Myotis lucifugus	82.13	0.00e+00	1319.00
IUUC-Ncr-068918	Neurospora crassa	48.36	1.00e-155	543.00
IUUC-Nle-069225	Nomascus leucogenys	81.64	0.00e+00	1320.00
IUUC-Ont-071664	Oreochromis niloticus	67.85	0.00e+00	1205.00
IUUC-Oan-073019	Ornithorhynchus anatinus	84.68	0.00e+00	1415.00
IUUC-Ocu-074409	Oryctolagus cuniculus	81.64	0.00e+00	1310.00
IUUC-Oga-088241	Otolemur garnettii	74.50	0.00e+00	1167.00
IUUC-Oar-089797	Ovis aries	81.22	0.00e+00	1389.00
IUUC-Ptr-091629	Pan troglodytes	81.74	0.00e+00	1206.00
IUUC-Psi-093618	Pelodiscus sinensis	90.31	0.00e+00	1393.00
IUUC-Pno-095118	Phaeosphaeria nodorum	49.23	1.00e-161	563.00
IUUC-Pfo-097145	Poecilia formosa	69.39	0.00e+00	1198.00
IUUC-Pab-098394	Pongo abelii	81.33	0.00e+00	1450.00
IUUC-Pca-100568	Procavia capensis	71.76	0.00e+00	1053.00
IUUC-Pte-104016	Pyrenophora teres	50.34	6.00e-161	560.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	50.34	6.00e-161	560.00
IUUC-Rno-106095	Rattus norvegicus	73.82	0.00e+00	1286.00
IUUC-Sha-107370	Sarcophilus harrisii	76.89	0.00e+00	1254.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.45	8.00e-154	537.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	47.50	2.00e-155	542.00
IUUC-Tru-117675	Takifugu rubripes	67.34	0.00e+00	1201.00
IUUC-Tni-119993	Tetraodon nigroviridis	65.13	0.00e+00	1165.00
IUUC-Tbe-127408	Tupaia belangeri	75.34	0.00e+00	1018.00
IUUC-Ttr-128437	Tursiops truncatus	73.75	0.00e+00	1017.00
IUUC-Uma-129332	Ustilago maydis	53.42	9.00e-142	497.00
IUUC-Vpa-130503	Vicugna pacos	76.56	0.00e+00	1130.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence