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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-032186
UUCD1 version UUC-DrM-00016
Ensembl Protein ID FBpp0089379
UniProt Accession Q7KRW1; Q7KRW0; Q8IHG9; Q8MQX1; Q8T0E3; Q8WRY2; Q9VAK6; TRC8_DROME
Genbank Protein ID AAL57300.1; AAF56900.1; AAS65223.1; AAL39520.1; AAM52762.1; AAN71016.1
Protein Name Protein TRC8 homolog
Genbank Nucleotide ID AF387786; AE014297; AE014297; AY069375; AY122250; BT001260
Gene Name Trc8; CG2304
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0039668 FBtr0085430 FBpp0084798
FBgn0039668 FBtr0085432 FBpp0089379
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20702414
Classification
Family E-value Score Start End
E3 activity/RING/RING 5.10e-07 30.2 621 658
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC++++    ++++C H+fh  Cl kw       + ++rCPlC
   Q: 621  CAICYQEMYS-AKITRCRHFFHGVCLRKW------LYVQDRCPLC 658
           ******9966.99****************......********** PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development.
 Plays a role in growth inhibition that is dependent upon COP9 signalosome subunits CSN5 and CSN6. May modulate signalosome levels or compartmentalization. Probably functions in the same or a related pathway to VHL during early midline development.
Protein Sequence
(Fasta)
MSVRTKVLGL VDVMMRVPPV MVIDEILKMD MGMQSWLYPD KDKASGALAT PTEAPAVPSG 60
QDPFTSIKEL FSHMTTSAQS VLEQSIEKAS EAAKTHGMLS SGFNSLMNEL SKDQTLADVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032186|E3,RING|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTAAACTCTG CCCAATAGTG TCTCTCTATC GCACACAGAA GGCTAGACCA GACCCTTTAG 60
AACGTAGTTT TTGAACAGAA TACCTAAAAT TACCAGTACC CCAGACCGAC ACGCAGCAAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032186|E3,RING|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13705--TRC8_N
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0045926--P:negative regulation of growth
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0007418--P:ventral midline development
KEGG dme:Dmel_CG2304
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002401 Ailuropoda melanoleuca 44.70 2.00e-103 369.00
IUUC-Apl-004214 Anas platyrhynchos 48.32 2.00e-105 375.00
IUUC-Aca-005326 Anolis carolinensis 45.20 1.00e-107 382.00
IUUC-Ame-011687 Astyanax mexicanus 47.80 8.00e-100 357.00
IUUC-Bta-013394 Bos taurus 41.88 3.00e-105 375.00
IUUC-Cel-018539 Caenorhabditis elegans 29.89 4.00e-31 129.00
IUUC-Cja-019499 Callithrix jacchus 44.47 2.00e-104 372.00
IUUC-Cfa-020357 Canis familiaris 44.93 6.00e-103 367.00
IUUC-Cpo-021924 Cavia porcellus 44.98 3.00e-105 375.00
IUUC-Csa-023513 Chlorocebus sabaeus 43.83 2.00e-103 368.00
IUUC-Cho-024285 Choloepus hoffmanni 41.16 1.00e-85 310.00
IUUC-Cin-025223 Ciona intestinalis 49.28 4.00e-67 247.00
IUUC-Csv-026018 Ciona savignyi 43.17 2.00e-56 211.00
IUUC-Dre-028660 Danio rerio 43.82 2.00e-92 332.00
IUUC-Dno-029463 Dasypus novemcinctus 56.04 1.00e-56 213.00
IUUC-Dor-030728 Dipodomys ordii 45.94 1.00e-105 376.00
IUUC-Ete-032368 Echinops telfairi 44.59 2.00e-105 375.00
IUUC-Eca-034325 Equus caballus 44.92 1.00e-103 370.00
IUUC-Eeu-035349 Erinaceus europaeus 60.24 6.00e-30 124.00
IUUC-Fca-035537 Felis catus 44.65 3.00e-104 371.00
IUUC-Fal-037459 Ficedula albicollis 48.45 3.00e-105 375.00
IUUC-Gmo-039442 Gadus morhua 50.76 1.00e-58 220.00
IUUC-Gga-041071 Gallus gallus 48.45 1.00e-106 379.00
IUUC-Gac-042483 Gasterosteus aculeatus 45.54 8.00e-104 370.00
IUUC-Ggo-044672 Gorilla gorilla 43.83 2.00e-103 369.00
IUUC-Hsa-045836 Homo sapiens 47.53 1.00e-102 366.00
IUUC-Itr-048588 Ictidomys tridecemlineatus 44.86 2.00e-105 375.00
IUUC-Lch-050073 Latimeria chalumnae 44.69 2.00e-104 372.00
IUUC-Loc-052908 Lepisosteus oculatus 44.42 1.00e-103 370.00
IUUC-Laf-053519 Loxodonta africana 41.48 2.00e-106 379.00
IUUC-Mcc-055779 Macaca mulatta 33.42 3.00e-53 202.00
IUUC-Meu-056130 Macropus eugenii 39.05 9.00e-37 147.00
IUUC-Mga-059922 Meleagris gallopavo 48.45 7.00e-107 380.00
IUUC-Mmr-061452 Microcebus murinus 48.05 6.00e-104 370.00
IUUC-Mdo-062412 Monodelphis domestica 44.35 3.00e-104 372.00
IUUC-Mmu-063147 Mus musculus 44.76 2.00e-104 372.00
IUUC-Mpu-065929 Mustela putorius furo 44.92 2.00e-103 369.00
IUUC-Mlu-067899 Myotis lucifugus 44.86 9.00e-104 370.00
IUUC-Nle-070083 Nomascus leucogenys 43.83 2.00e-103 369.00
IUUC-Opr-070461 Ochotona princeps 45.56 2.00e-105 375.00
IUUC-Ont-072256 Oreochromis niloticus 44.84 5.00e-101 361.00
IUUC-Oan-073150 Ornithorhynchus anatinus 48.20 1.00e-102 366.00
IUUC-Ocu-073748 Oryctolagus cuniculus 48.57 4.00e-105 374.00
IUUC-Ola-087368 Oryzias latipes 31.32 1.00e-52 200.00
IUUC-Oga-088565 Otolemur garnettii 44.49 2.00e-104 372.00
IUUC-Oar-089432 Ovis aries 42.23 8.00e-106 376.00
IUUC-Ptr-091422 Pan troglodytes 43.83 2.00e-103 369.00
IUUC-Pan-092331 Papio anubis 43.83 2.00e-103 369.00
IUUC-Psi-092933 Pelodiscus sinensis 48.20 3.00e-105 375.00
IUUC-Pma-094457 Petromyzon marinus 31.03 4.00e-46 178.00
IUUC-Pfo-097466 Poecilia formosa 40.79 3.00e-101 362.00
IUUC-Pab-098702 Pongo abelii 43.83 2.00e-103 369.00
IUUC-Pca-100125 Procavia capensis 44.40 2.00e-106 379.00
IUUC-Pva-102628 Pteropus vampyrus 43.57 5.00e-103 367.00
IUUC-Rno-104886 Rattus norvegicus 40.51 6.00e-105 374.00
IUUC-Sha-106702 Sarcophilus harrisii 44.12 2.00e-103 369.00
IUUC-Ssc-115482 Sus scrofa 45.54 7.00e-106 377.00
IUUC-Tgu-116829 Taeniopygia guttata 48.45 4.00e-106 378.00
IUUC-Tru-118557 Takifugu rubripes 49.74 8.00e-104 370.00
IUUC-Tsy-119399 Tarsius syrichta 44.49 1.00e-51 196.00
IUUC-Tni-120006 Tetraodon nigroviridis 47.07 5.00e-94 337.00
IUUC-Tbe-127664 Tupaia belangeri 45.15 4.00e-104 371.00
IUUC-Ttr-129144 Tursiops truncatus 42.45 3.00e-106 378.00
IUUC-Vpa-130226 Vicugna pacos 44.49 6.00e-104 370.00
IUUC-Xtr-132461 Xenopus tropicalis 48.20 5.00e-106 377.00
Created Date 25-Jun-2017

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