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Tag Content
UUCD2 ID IUUC-Aml-002009
UUCD1 version UUC-AiM-00398
Ensembl Protein ID ENSAMEP00000017665.1
UniProt Accession D2H640; D2H640_AILME
Genbank Protein ID EFB20609.1
Protein Name Tyrosine-protein kinase
Genbank Nucleotide ID ACTA01032624
Gene Name FYN; PANDA_005413
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMEG00000016721.1 ENSAMET00000018385.1 ENSAMEP00000017665.1
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.60e-15 56.2 87 142
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L+++kG++ +++  ++ +++W+++ + ++g  G +P+n+v+ ++
   Q: 87   FVALYDYEARTEDDLSFHKGEKFQIL--NSSEGDWWEARSLTTGETGYIPSNYVAPVD 142
           789***********************..89999*********************9987 PP
   
Organism Ailuropoda melanoleuca
Protein Sequence
(Fasta)
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG 60
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Aml-002009|UBD,SH3|Ailuropoda melanoleuca
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCTGTG TGCAATGTAA GGATAAAGAA GCAACAAAAC TGACGGAGGA GAGGGATGGC 60
AGCCTGAACC AGAGCTCCGG GTACCGCTAT GGCACAGACC CCACTCCGCA GCACTACCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Aml-002009|UBD,SH3|Ailuropoda melanoleuca
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005884--C:actin filament
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005768--C:endosome
GO:0045121--C:membrane raft
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004871--F:signal transducer activity
GO:0050798--P:activated T cell proliferation
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0071560--P:cellular response to transforming growth factor beta stimulus
GO:0048813--P:dendrite morphogenesis
GO:0050966--P:detection of mechanical stimulus involved in sensory perception of pain
GO:0030900--P:forebrain development
GO:1902951--P:negative regulation of dendritic spine maintenance
GO:0010629--P:negative regulation of gene expression
GO:0042177--P:negative regulation of protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001764--P:neuron migration
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901216--P:positive regulation of neuron death
GO:0010976--P:positive regulation of neuron projection development
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0090314--P:positive regulation of protein targeting to membrane
GO:0042523--P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777--P:protein autophosphorylation
GO:1905664--P:regulation of calcium ion import across plasma membrane
GO:0008360--P:regulation of cell shape
GO:1904645--P:response to beta-amyloid
GO:0045471--P:response to ethanol
GO:0050852--P:T cell receptor signaling pathway
KEGG aml:100470931
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Apl-003716 Anas platyrhynchos 92.95 0.00e+00 1004.00
IUUC-Aca-005065 Anolis carolinensis 99.07 0.00e+00 1082.00
IUUC-Ame-011533 Astyanax mexicanus 94.95 0.00e+00 911.00
IUUC-Bta-012645 Bos taurus 99.81 0.00e+00 1090.00
IUUC-Cel-018682 Caenorhabditis elegans 57.68 6.00e-150 523.00
IUUC-Cja-019027 Callithrix jacchus 100.00 0.00e+00 1092.00
IUUC-Cfa-021163 Canis familiaris 100.00 0.00e+00 1092.00
IUUC-Cpo-022315 Cavia porcellus 100.00 0.00e+00 1092.00
IUUC-Csa-023721 Chlorocebus sabaeus 99.81 0.00e+00 1090.00
IUUC-Cho-025014 Choloepus hoffmanni 99.81 0.00e+00 1090.00
IUUC-Dre-027985 Danio rerio 92.36 0.00e+00 1054.00
IUUC-Dno-030043 Dasypus novemcinctus 90.83 0.00e+00 1063.00
IUUC-Dor-031035 Dipodomys ordii 98.70 0.00e+00 1073.00
IUUC-Dme-031976 Drosophila melanogaster 60.65 2.00e-164 572.00
IUUC-Eca-033928 Equus caballus 90.21 0.00e+00 829.00
IUUC-Eeu-034582 Erinaceus europaeus 99.14 0.00e+00 687.00
IUUC-Fca-035582 Felis catus 100.00 0.00e+00 1092.00
IUUC-Fal-037320 Ficedula albicollis 93.30 0.00e+00 1009.00
IUUC-Gmo-038992 Gadus morhua 90.72 0.00e+00 1033.00
IUUC-Gga-041262 Gallus gallus 93.30 0.00e+00 1009.00
IUUC-Gac-042461 Gasterosteus aculeatus 90.50 0.00e+00 1035.00
IUUC-Ggo-044469 Gorilla gorilla 98.88 0.00e+00 1085.00
IUUC-Hsa-045723 Homo sapiens 99.81 0.00e+00 1090.00
IUUC-Itr-048519 Ictidomys tridecemlineatus 100.00 0.00e+00 1092.00
IUUC-Lch-049825 Latimeria chalumnae 92.74 0.00e+00 1012.00
IUUC-Loc-052531 Lepisosteus oculatus 91.43 0.00e+00 1044.00
IUUC-Laf-053659 Loxodonta africana 99.81 0.00e+00 1090.00
IUUC-Mcc-055039 Macaca mulatta 93.73 0.00e+00 1018.00
IUUC-Mga-060067 Meleagris gallopavo 98.88 0.00e+00 1078.00
IUUC-Mmr-061194 Microcebus murinus 100.00 0.00e+00 1092.00
IUUC-Mdo-062628 Monodelphis domestica 99.81 0.00e+00 1090.00
IUUC-Mmu-063896 Mus musculus 99.63 0.00e+00 1088.00
IUUC-Mpu-066333 Mustela putorius furo 99.63 0.00e+00 1088.00
IUUC-Mlu-067315 Myotis lucifugus 100.00 0.00e+00 1092.00
IUUC-Nle-068978 Nomascus leucogenys 94.23 0.00e+00 1018.00
IUUC-Ont-072516 Oreochromis niloticus 91.81 0.00e+00 1050.00
IUUC-Oan-073714 Ornithorhynchus anatinus 99.78 0.00e+00 950.00
IUUC-Ocu-074284 Oryctolagus cuniculus 99.81 0.00e+00 1090.00
IUUC-Ola-087431 Oryzias latipes 91.62 0.00e+00 1047.00
IUUC-Oga-088789 Otolemur garnettii 94.23 0.00e+00 1017.00
IUUC-Oar-089408 Ovis aries 99.81 0.00e+00 1090.00
IUUC-Ptr-091068 Pan troglodytes 99.81 0.00e+00 1090.00
IUUC-Pan-092217 Papio anubis 99.81 0.00e+00 1090.00
IUUC-Psi-093602 Pelodiscus sinensis 98.88 0.00e+00 1080.00
IUUC-Pfo-097084 Poecilia formosa 92.18 0.00e+00 1053.00
IUUC-Pab-097673 Pongo abelii 99.44 0.00e+00 1086.00
IUUC-Pca-100245 Procavia capensis 97.74 0.00e+00 973.00
IUUC-Pva-102645 Pteropus vampyrus 98.13 0.00e+00 1054.00
IUUC-Rno-105372 Rattus norvegicus 99.81 0.00e+00 1090.00
IUUC-Sha-107637 Sarcophilus harrisii 99.44 0.00e+00 1077.00
IUUC-Sar-113016 Sorex araneus 88.64 0.00e+00 946.00
IUUC-Ssc-116389 Sus scrofa 99.63 0.00e+00 1085.00
IUUC-Tgu-117206 Taeniopygia guttata 93.30 0.00e+00 1009.00
IUUC-Tru-118241 Takifugu rubripes 90.94 0.00e+00 1042.00
IUUC-Tni-120031 Tetraodon nigroviridis 91.62 0.00e+00 1043.00
IUUC-Tbe-127707 Tupaia belangeri 96.95 0.00e+00 973.00
IUUC-Ttr-129145 Tursiops truncatus 100.00 0.00e+00 1092.00
IUUC-Vpa-130815 Vicugna pacos 97.19 0.00e+00 1036.00
IUUC-Xtr-132293 Xenopus tropicalis 90.50 0.00e+00 981.00
Created Date 25-Jun-2017

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