iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oan-073304

Ensembl Protein ID

ENSOANP00000022369.2

UniProt Accession

F7C7L3; F7C7L3_ORNAN

Genbank Protein ID

ENSOANP00000022369

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01039930

Gene Name

NCK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000014187.2	ENSOANT00000022373.2	ENSOANP00000022369.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-34	117.7	134	192

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+ +g+ Gl+P+n+v+ l
   Q: 134  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNSRGQIGLVPKNYVVIL 192
           589**************************************.7**************866 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MPIRLFLFIF TGLGKTKRKT SARDASPTPS TDAEYPSNGS SGADRIYDLN IPAYVKFAYV 60
AEREDELSLV KGSRVVVMEK CSDGWWRGSY NGQIGWFPSN YVVEEVEEAT ADSPSFLSLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTGAAACT CTATGCCCAT CAGGCTCTTC CTTTTTATTT TCACAGGGCT GGGTAAAACC 60
AAAAGAAAGA CCAGTGCCCG AGATGCCTCC CCAACTCCTA GCACGGATGC GGAGTATCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0012506--C:vesicle membrane
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	90.85	4.00e-164	569.00
IUUC-Apl-003456	Anas platyrhynchos	95.42	2.00e-168	584.00
IUUC-Aca-005105	Anolis carolinensis	94.77	5.00e-168	582.00
IUUC-Ame-010966	Astyanax mexicanus	74.76	2.00e-132	464.00
IUUC-Bta-012424	Bos taurus	82.03	3.00e-137	480.00
IUUC-Cel-018144	Caenorhabditis elegans	42.70	2.00e-55	209.00
IUUC-Cja-019898	Callithrix jacchus	91.50	2.00e-165	574.00
IUUC-Cfa-020830	Canis familiaris	89.87	6.00e-163	566.00
IUUC-Cpo-021487	Cavia porcellus	81.05	1.00e-139	488.00
IUUC-Csa-023693	Chlorocebus sabaeus	91.83	1.00e-165	575.00
IUUC-Cin-025348	Ciona intestinalis	39.74	4.00e-52	198.00
IUUC-Dre-028334	Danio rerio	78.96	6.00e-136	476.00
IUUC-Dno-028973	Dasypus novemcinctus	92.16	4.00e-166	576.00
IUUC-Dor-031003	Dipodomys ordii	89.58	8.00e-158	548.00
IUUC-Ete-032792	Echinops telfairi	82.52	9.00e-148	515.00
IUUC-Eca-033656	Equus caballus	91.50	3.00e-165	573.00
IUUC-Eeu-035169	Erinaceus europaeus	77.18	1.00e-93	335.00
IUUC-Fca-036347	Felis catus	91.18	2.00e-164	571.00
IUUC-Fal-037095	Ficedula albicollis	95.42	1.00e-168	585.00
IUUC-Gmo-039410	Gadus morhua	66.88	2.00e-122	431.00
IUUC-Gga-040155	Gallus gallus	95.42	2.00e-168	584.00
IUUC-Gac-041787	Gasterosteus aculeatus	69.28	1.00e-125	442.00
IUUC-Ggo-044805	Gorilla gorilla	91.83	8.00e-166	575.00
IUUC-Hsa-046585	Homo sapiens	91.83	8.00e-166	575.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	89.54	3.00e-157	547.00
IUUC-Lch-049795	Latimeria chalumnae	89.54	4.00e-159	553.00
IUUC-Loc-051985	Lepisosteus oculatus	88.24	8.00e-151	525.00
IUUC-Laf-054228	Loxodonta africana	93.46	1.00e-166	578.00
IUUC-Mcc-055402	Macaca mulatta	91.83	1.00e-165	575.00
IUUC-Mga-059374	Meleagris gallopavo	95.42	2.00e-168	584.00
IUUC-Mmr-061453	Microcebus murinus	90.85	8.00e-165	572.00
IUUC-Mdo-063080	Monodelphis domestica	95.10	2.00e-169	587.00
IUUC-Mmu-063529	Mus musculus	87.58	7.00e-156	542.00
IUUC-Mpu-066815	Mustela putorius furo	90.85	4.00e-164	569.00
IUUC-Mlu-067132	Myotis lucifugus	88.56	2.00e-158	550.00
IUUC-Nle-069371	Nomascus leucogenys	91.83	8.00e-166	575.00
IUUC-Opr-070948	Ochotona princeps	90.43	4.00e-153	533.00
IUUC-Ont-071410	Oreochromis niloticus	71.12	1.00e-121	428.00
IUUC-Ocu-074783	Oryctolagus cuniculus	90.85	6.00e-159	552.00
IUUC-Ola-086808	Oryzias latipes	68.47	8.00e-119	419.00
IUUC-Oga-088391	Otolemur garnettii	91.50	2.00e-161	560.00
IUUC-Oar-090025	Ovis aries	74.84	7.00e-121	426.00
IUUC-Ptr-090975	Pan troglodytes	91.83	8.00e-166	575.00
IUUC-Pan-092287	Papio anubis	91.83	1.00e-165	575.00
IUUC-Psi-093413	Pelodiscus sinensis	96.08	3.00e-169	586.00
IUUC-Pfo-097129	Poecilia formosa	73.44	3.00e-128	450.00
IUUC-Pab-098756	Pongo abelii	91.83	8.00e-166	575.00
IUUC-Pca-100235	Procavia capensis	77.45	2.00e-139	488.00
IUUC-Pva-102294	Pteropus vampyrus	90.85	5.00e-163	566.00
IUUC-Rno-105090	Rattus norvegicus	87.58	6.00e-156	542.00
IUUC-Sha-107521	Sarcophilus harrisii	95.10	4.00e-170	590.00
IUUC-Sar-113697	Sorex araneus	82.52	3.00e-144	503.00
IUUC-Ssc-115958	Sus scrofa	80.58	2.00e-118	417.00
IUUC-Tgu-116559	Taeniopygia guttata	92.81	2.00e-161	560.00
IUUC-Tru-117677	Takifugu rubripes	71.88	1.00e-124	438.00
IUUC-Tni-120434	Tetraodon nigroviridis	71.92	8.00e-123	432.00
IUUC-Tbe-127931	Tupaia belangeri	89.67	6.00e-133	466.00
IUUC-Ttr-128993	Tursiops truncatus	80.72	1.00e-138	484.00
IUUC-Xtr-132543	Xenopus tropicalis	84.04	2.00e-151	528.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence