iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.40e-13	51.4	24	87

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalf.lmeleesksklmveikdvqpevfrallkFlYtgkl 65
           +D+++ +++++f+ahk+vLaa+Ss+F+  f +++ +  +  +  ++k +++e+f  +l+F+Y gk+
   Q: 24   CDCCIAIDDTYFQAHKAVLAACSSYFRMFFmNHQHSTAQ-LNLSNMK-ISAECFDLILQFMYLGKI 87
           8*************************9999333333333.5555666.***************996 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAKPSHSSYV LQQLNNQREW GFLCDCCIAI DDTYFQAHKA VLAACSSYFR MFFMNHQHST 60
AQLNLSNMKI SAECFDLILQ FMYLGKILTA PSSFEQFKVA MNYLQLYNVP DCLEDIQDSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCGGAGCC GGAGGCCGCA GACTTGGGCG CGCTCCGAGG GAGGAGGCGG CTGGGCCGCG 60
CGGATTCCTG CTTCGCTCTT TCCCACCCCC GCTCCTCAGC ACACACGCTT TTTGTTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0016604--C:nuclear body
GO:0031965--C:nuclear membrane
GO:0046872--F:metal ion binding
GO:0003676--F:nucleic acid binding
GO:0030183--P:B cell differentiation
GO:0034644--P:cellular response to UV
GO:0006338--P:chromatin remodeling
GO:0042789--P:mRNA transcription from RNA polymerase II promoter
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032825--P:positive regulation of natural killer cell differentiation
GO:2000176--P:positive regulation of pro-T cell differentiation
GO:0002711--P:positive regulation of T cell mediated immunity
GO:0051260--P:protein homooligomerization
GO:0033077--P:T cell differentiation in thymus
GO:0048538--P:thymus development
GO:0019985--P:translesion synthesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001844	Ailuropoda melanoleuca	91.15	0.00e+00	1125.00
IUUC-Apl-003725	Anas platyrhynchos	76.95	0.00e+00	922.00
IUUC-Aca-004672	Anolis carolinensis	65.89	0.00e+00	763.00
IUUC-Ame-011859	Astyanax mexicanus	45.26	1.00e-132	467.00
IUUC-Bta-013323	Bos taurus	91.79	0.00e+00	1164.00
IUUC-Cja-018727	Callithrix jacchus	91.31	0.00e+00	1127.00
IUUC-Cfa-020390	Canis familiaris	91.46	0.00e+00	1141.00
IUUC-Cpo-022434	Cavia porcellus	90.66	0.00e+00	1155.00
IUUC-Csa-023909	Chlorocebus sabaeus	89.92	0.00e+00	1133.00
IUUC-Cho-024288	Choloepus hoffmanni	89.47	0.00e+00	879.00
IUUC-Dre-027623	Danio rerio	43.66	2.00e-134	473.00
IUUC-Dno-029224	Dasypus novemcinctus	91.63	0.00e+00	1164.00
IUUC-Ete-032672	Echinops telfairi	86.15	0.00e+00	927.00
IUUC-Eca-034361	Equus caballus	90.85	0.00e+00	1146.00
IUUC-Eeu-035254	Erinaceus europaeus	86.08	8.00e-148	517.00
IUUC-Fca-036217	Felis catus	90.84	0.00e+00	1154.00
IUUC-Fal-037026	Ficedula albicollis	75.00	0.00e+00	933.00
IUUC-Gga-040550	Gallus gallus	74.79	2.00e-136	478.00
IUUC-Gac-041379	Gasterosteus aculeatus	42.27	9.00e-124	437.00
IUUC-Ggo-044852	Gorilla gorilla	91.94	0.00e+00	1165.00
IUUC-Hsa-046418	Homo sapiens	92.10	0.00e+00	1166.00
IUUC-Itr-048065	Ictidomys tridecemlineatus	90.84	0.00e+00	1150.00
IUUC-Lch-050025	Latimeria chalumnae	50.62	1.00e-174	606.00
IUUC-Loc-052590	Lepisosteus oculatus	46.06	2.00e-141	496.00
IUUC-Laf-054526	Loxodonta africana	90.69	0.00e+00	1140.00
IUUC-Mcc-055796	Macaca mulatta	90.21	0.00e+00	1110.00
IUUC-Mga-059889	Meleagris gallopavo	76.79	0.00e+00	939.00
IUUC-Mmr-061304	Microcebus murinus	91.15	0.00e+00	1125.00
IUUC-Mdo-062964	Monodelphis domestica	84.04	0.00e+00	1061.00
IUUC-Mmu-064268	Mus musculus	93.83	0.00e+00	1192.00
IUUC-Mpu-065817	Mustela putorius furo	90.23	0.00e+00	1142.00
IUUC-Mlu-068225	Myotis lucifugus	90.84	0.00e+00	1134.00
IUUC-Nle-069390	Nomascus leucogenys	91.79	0.00e+00	1163.00
IUUC-Opr-070274	Ochotona princeps	88.78	0.00e+00	1102.00
IUUC-Ont-072145	Oreochromis niloticus	41.74	2.00e-124	439.00
IUUC-Oan-073144	Ornithorhynchus anatinus	82.70	0.00e+00	979.00
IUUC-Ocu-074835	Oryctolagus cuniculus	84.83	0.00e+00	1036.00
IUUC-Ola-087520	Oryzias latipes	50.38	1.00e-63	237.00
IUUC-Oga-088605	Otolemur garnettii	91.15	0.00e+00	1146.00
IUUC-Oar-089788	Ovis aries	91.79	0.00e+00	1164.00
IUUC-Ptr-091274	Pan troglodytes	92.10	0.00e+00	1166.00
IUUC-Psi-093560	Pelodiscus sinensis	75.96	0.00e+00	965.00
IUUC-Pfo-097221	Poecilia formosa	40.93	5.00e-120	425.00
IUUC-Pab-097799	Pongo abelii	91.78	0.00e+00	1191.00
IUUC-Pva-102769	Pteropus vampyrus	89.89	0.00e+00	1132.00
IUUC-Sha-106613	Sarcophilus harrisii	83.89	0.00e+00	1055.00
IUUC-Sar-112951	Sorex araneus	81.21	0.00e+00	1045.00
IUUC-Ssc-115673	Sus scrofa	91.31	0.00e+00	1126.00
IUUC-Tgu-116806	Taeniopygia guttata	75.39	0.00e+00	902.00
IUUC-Tru-117544	Takifugu rubripes	43.56	2.00e-132	466.00
IUUC-Tsy-119233	Tarsius syrichta	83.41	0.00e+00	1012.00
IUUC-Tni-120273	Tetraodon nigroviridis	40.50	5.00e-113	401.00
IUUC-Tbe-128020	Tupaia belangeri	88.22	0.00e+00	1134.00
IUUC-Ttr-128357	Tursiops truncatus	91.15	0.00e+00	1116.00
IUUC-Vpa-130487	Vicugna pacos	91.47	0.00e+00	1162.00
IUUC-Xtr-132415	Xenopus tropicalis	54.55	0.00e+00	629.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence