iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046938

Ensembl Protein ID

ENSP00000358762.3

UniProt Accession

Q7Z6J8; B4DP63; Q5T4W2; Q6IPR4; Q75UG0; Q9NT42; UBE3D_HUMAN

Genbank Protein ID

BAD01604.1; BAG60475.1; CAM28304.1; CAM28304.1; CAM28304.1; CAM28304.1; CAI15282.2; CAI15282.2; CAI15282.2; CAI15282.2; CAI13740.2; CAI13740.2; CAI13740.2; CAI13740.2; EAW48681.1; AAH53645.1; AAH71763.1; AAI01513.1; AAI01539.1; CAB70802.1

Protein Name

E3 ubiquitin-protein ligase E3D; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein

Genbank Nucleotide ID

AB126062; AK298205; AL034377; AL139333; AL357121; AL355613; AL139333; AL034377; AL357121; AL355613; AL357121; AL034377; AL139333; AL355613; CH471051; BC053645; BC071763; BC101512; BC101538; AL137544

Gene Name

UBE3D; C6orf157; H10BH; UBE2CBP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000118420.16	ENST00000369747.7	ENSP00000358762.3
ENSG00000118420.16	ENST00000237186.10	ENSP00000237186.6
ENSG00000118420.16	ENST00000509102.5	ENSP00000427101.1
ENSG00000118420.16	ENST00000369746.2	ENSP00000358761.2
ENSG00000118420.16	ENST00000505226.1	ENSP00000422755.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	15749827

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.

Protein Sequence
(Fasta)

MAASAAETRV FLEVRGQLQS ALLILGEPKE GGMPMNISIM PSSLQMKTPE GCTEIQLPAE 60
VRLVPSSCRG LQFVVGDGLH LRLQTQAKLG TKLISMFNQS SQTQECCTFY CQSCGEVIIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGGCGCCT GCGCCGCAGC GGGGCTGCCG CTGGTTGGTC CGCACGTGGA ACCTCTCCTG 60
GTCCTGTTGA CCCGGGCCCC TCGGAACCTC CAGCTTGGTC CGGTCTGGGA CTGGAAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR019193--UBQ-conj_enz_E2-bd_prot

Pfam

PF09814--HECT_2

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016740--F:transferase activity
GO:0016567--P:protein ubiquitination

KEGG

hsa:90025

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002283	Ailuropoda melanoleuca	80.99	0.00e+00	641.00
IUUC-Apl-003735	Anas platyrhynchos	57.48	3.00e-88	318.00
IUUC-Ago-007913	Ashbya gossypii	18.77	1.00e-04	40.80
IUUC-Acl-008059	Aspergillus clavatus	25.50	6.00e-05	42.40
IUUC-Ame-011464	Astyanax mexicanus	37.78	4.00e-72	265.00
IUUC-Bgr-012278	Blumeria graminis	43.14	2.00e-06	47.00
IUUC-Bta-013117	Bos taurus	77.63	1.00e-178	618.00
IUUC-Bci-013655	Botrytis cinerea	21.26	4.00e-05	42.70
IUUC-Cel-018650	Caenorhabditis elegans	23.30	2.00e-03	37.00
IUUC-Cja-019652	Callithrix jacchus	91.07	3.00e-177	613.00
IUUC-Cfa-020496	Canis familiaris	83.03	0.00e+00	670.00
IUUC-Cpo-021497	Cavia porcellus	77.22	1.00e-154	539.00
IUUC-Csa-023348	Chlorocebus sabaeus	94.09	0.00e+00	751.00
IUUC-Cho-024538	Choloepus hoffmanni	80.31	0.00e+00	640.00
IUUC-Cin-025117	Ciona intestinalis	25.15	2.00e-23	104.00
IUUC-Csv-026319	Ciona savignyi	26.30	6.00e-21	95.10
IUUC-Cgl-026609	Colletotrichum gloeosporioides	22.70	4.00e-04	39.30
IUUC-Dre-028413	Danio rerio	37.13	2.00e-62	233.00
IUUC-Dno-029642	Dasypus novemcinctus	70.87	2.00e-138	484.00
IUUC-Dor-031050	Dipodomys ordii	71.54	1.00e-107	382.00
IUUC-Dse-031533	Dothistroma septosporum	20.91	8.00e-03	35.00
IUUC-Dme-031861	Drosophila melanogaster	26.77	7.00e-03	35.80
IUUC-Ete-032451	Echinops telfairi	65.50	1.00e-78	286.00
IUUC-Eca-034131	Equus caballus	84.01	2.00e-146	511.00
IUUC-Fca-036591	Felis catus	83.66	1.00e-177	615.00
IUUC-Fal-037294	Ficedula albicollis	53.35	4.00e-90	325.00
IUUC-Fox-037718	Fusarium oxysporum	20.20	3.00e-03	36.60
IUUC-Gmo-039559	Gadus morhua	32.46	3.00e-48	186.00
IUUC-Ggr-039897	Gaeumannomyces graminis	29.79	3.00e-03	36.60
IUUC-Gga-040698	Gallus gallus	54.45	1.00e-104	373.00
IUUC-Gac-041989	Gasterosteus aculeatus	34.10	2.00e-55	209.00
IUUC-Ggo-044662	Gorilla gorilla	97.43	0.00e+00	776.00
IUUC-Itr-048017	Ictidomys tridecemlineatus	76.70	6.00e-144	503.00
IUUC-Kpa-049106	Komagataella pastoris	31.58	2.00e-01	30.00
IUUC-Lch-049813	Latimeria chalumnae	44.99	1.00e-80	293.00
IUUC-Loc-052595	Lepisosteus oculatus	41.21	2.00e-78	286.00
IUUC-Lma-053011	Leptosphaeria maculans	31.25	3.00e-05	43.90
IUUC-Laf-054445	Loxodonta africana	81.49	0.00e+00	647.00
IUUC-Mcc-054983	Macaca mulatta	93.83	0.00e+00	747.00
IUUC-Meu-055908	Macropus eugenii	51.51	1.00e-88	320.00
IUUC-Mpo-057474	Magnaporthe poae	25.00	2.30e-01	30.40
IUUC-Mla-059182	Melampsora laricipopulina	30.77	1.00e-03	38.50
IUUC-Mga-059309	Meleagris gallopavo	52.55	1.00e-70	259.00
IUUC-Mvi-060250	Microbotryum violaceum	24.00	2.00e-11	65.50
IUUC-Mmr-061565	Microcebus murinus	83.80	0.00e+00	656.00
IUUC-Mdo-062560	Monodelphis domestica	65.97	3.00e-142	498.00
IUUC-Mmu-064310	Mus musculus	74.29	2.00e-163	568.00
IUUC-Mpu-066767	Mustela putorius furo	82.63	4.00e-173	600.00
IUUC-Mlu-068164	Myotis lucifugus	78.81	1.00e-158	551.00
IUUC-Nle-070103	Nomascus leucogenys	94.60	0.00e+00	751.00
IUUC-Opr-070428	Ochotona princeps	71.90	2.00e-149	521.00
IUUC-Ont-071622	Oreochromis niloticus	36.13	9.00e-63	234.00
IUUC-Oan-072809	Ornithorhynchus anatinus	60.62	5.00e-96	344.00
IUUC-Ocu-074517	Oryctolagus cuniculus	77.89	7.00e-178	616.00
IUUC-Ola-086813	Oryzias latipes	34.65	3.00e-50	192.00
IUUC-Oga-087958	Otolemur garnettii	67.26	2.00e-142	498.00
IUUC-Oar-089790	Ovis aries	74.93	7.00e-147	513.00
IUUC-Ptr-091239	Pan troglodytes	98.20	0.00e+00	783.00
IUUC-Pan-092265	Papio anubis	94.60	0.00e+00	755.00
IUUC-Psi-094083	Pelodiscus sinensis	60.21	1.00e-127	449.00
IUUC-Pfo-097062	Poecilia formosa	34.95	2.00e-52	199.00
IUUC-Pab-098283	Pongo abelii	87.40	0.00e+00	681.00
IUUC-Pca-100292	Procavia capensis	67.35	2.00e-144	505.00
IUUC-Pva-103005	Pteropus vampyrus	80.85	5.00e-180	623.00
IUUC-Pgr-103566	Puccinia graminis	28.77	1.00e-03	38.10
IUUC-Pyt-104623	Pyrenophora triticirepentis	23.38	1.20e-01	31.60
IUUC-Rno-105052	Rattus norvegicus	73.52	3.00e-167	581.00
IUUC-Sce-106419	Saccharomyces cerevisiae	21.48	2.00e-07	50.10
IUUC-Sha-107214	Sarcophilus harrisii	60.32	2.00e-106	378.00
IUUC-Sly-111095	Solanum lycopersicum	25.58	9.60e-02	31.20
IUUC-Sar-112980	Sorex araneus	77.38	7.00e-179	619.00
IUUC-Ssc-115639	Sus scrofa	80.18	1.00e-105	375.00
IUUC-Tgu-117021	Taeniopygia guttata	52.22	5.00e-93	334.00
IUUC-Tru-117965	Takifugu rubripes	37.19	2.00e-63	236.00
IUUC-Tsy-119482	Tarsius syrichta	75.81	5.00e-131	460.00
IUUC-Tni-119773	Tetraodon nigroviridis	35.59	3.00e-48	185.00
IUUC-Tca-121134	Theobroma cacao	35.56	3.70e-02	30.80
IUUC-Tre-121976	Trichoderma reesei	20.66	6.00e-05	41.60
IUUC-Tvi-122374	Trichoderma virens	26.42	2.90e-02	33.10
IUUC-Tae-123901	Triticum aestivum	27.27	7.00e-03	32.00
IUUC-Tme-127047	Tuber melanosporum	23.85	1.00e-04	41.20
IUUC-Tbe-127606	Tupaia belangeri	71.96	9.00e-70	257.00
IUUC-Ttr-128711	Tursiops truncatus	78.71	3.00e-174	604.00
IUUC-Vpa-130345	Vicugna pacos	67.49	1.00e-139	489.00
IUUC-Xtr-132567	Xenopus tropicalis	47.52	4.00e-90	325.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence