iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118206

UUCD1 version

UUC-TaR-00976

Ensembl Protein ID

ENSTRUP00000045474.1

UniProt Accession

H2V8D5; H2V8D5_TAKRU

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000017737.1	ENSTRUT00000045627.1	ENSTRUP00000045474.1
ENSTRUG00000017737.1	ENSTRUT00000045628.1	ENSTRUP00000045475.1
ENSTRUG00000017737.1	ENSTRUT00000045629.1	ENSTRUP00000045476.1
ENSTRUG00000017737.1	ENSTRUT00000045630.1	ENSTRUP00000045477.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-100	337.8	734	1057

Active Site

Position(s)	Description	Evidence
1026	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l++kel +p++g+f+y e+++  ++ n++      e+++lF+++G+++g+a+++  +++l
   Q: 734  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELMDPKYGMFRYYEESRLIWFSNKTF-----EEFDLFNLIGIICGLAIYNLTIVEL 815
           78999***********************************************99977.....68*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk +l+dl+e+ p++ +sl+ ++++ e+d+ee+ ++l+f+++ee++g t++ eL+p+Geni+V+++N++e+v+++
   Q: 816  QFPVALYKKLLKKKPTLDDLKELTPDVGRSLQALLDYPEDDLEET-FCLNFTITEENYGATEVFELIPNGENISVNKSNRQEFVNAY 901
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++++++  +e f++Gf++v+  ++l+lF+++el+ ++ G++++d+ +l+k t+ykg+y +d+p+i+ Fwev++++  +++k+f
   Q: 902  VDYVFNTSVAPLFEYFYAGFHKVCGGKVLELFQPNELQAMVIGNTSYDWAELEKSTEYKGEYWKDHPTIKLFWEVFHSLPLQKKKQF 988
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP ++TCfn+L+LP+Y+s e+l+ekLl Ai++++gF+l
   Q: 989  LLFLTGSDRIPILGMKSLK---LVIQPtGGGEHYLPVAHTCFNLLDLPKYTSTETLREKLLHAIDHNQGFNL 1057
           *******************...6666658889**************************************87 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVIEPRKCEF FHGKKVCDVG CGLKHTVFLL DDGTVYTCGC 60
NDLGQLGHEK PRKKPEHVVA LDAQIIVAVS GGESHTLALN DKGQIFSWGL GSDGQLGLNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGTGCT GGGGAAATGC CTCCTACGGA CAGTTAGGTT TGGGTGGGAT TGATGAGGAG 60
ATTGTGATTG AACCAAGAAA ATGTGAATTC TTTCACGGGA AGAAAGTCTG TGACGTGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	72.98	0.00e+00	1504.00
IUUC-Apl-003295	Anas platyrhynchos	71.98	0.00e+00	1533.00
IUUC-Aca-004336	Anolis carolinensis	71.98	0.00e+00	1535.00
IUUC-Ame-010768	Astyanax mexicanus	75.98	0.00e+00	1639.00
IUUC-Bta-013279	Bos taurus	72.70	0.00e+00	1503.00
IUUC-Cel-018150	Caenorhabditis elegans	33.49	7.00e-152	531.00
IUUC-Cja-019023	Callithrix jacchus	73.08	0.00e+00	1503.00
IUUC-Cfa-021074	Canis familiaris	73.08	0.00e+00	1506.00
IUUC-Cpo-021461	Cavia porcellus	71.54	0.00e+00	1464.00
IUUC-Csa-024261	Chlorocebus sabaeus	73.08	0.00e+00	1504.00
IUUC-Cin-025232	Ciona intestinalis	42.30	0.00e+00	814.00
IUUC-Cme-027151	Cyanidioschyzon merolae	30.20	1.00e-102	368.00
IUUC-Dre-028829	Danio rerio	77.04	0.00e+00	1623.00
IUUC-Dno-029445	Dasypus novemcinctus	69.87	0.00e+00	1190.00
IUUC-Dor-030158	Dipodomys ordii	76.24	0.00e+00	710.00
IUUC-Dme-032103	Drosophila melanogaster	43.48	0.00e+00	854.00
IUUC-Ete-033072	Echinops telfairi	66.13	0.00e+00	1320.00
IUUC-Eca-033317	Equus caballus	72.68	0.00e+00	1497.00
IUUC-Fca-035682	Felis catus	73.03	0.00e+00	1506.00
IUUC-Fal-036969	Ficedula albicollis	71.09	0.00e+00	1529.00
IUUC-Gmo-038671	Gadus morhua	78.90	0.00e+00	1691.00
IUUC-Gga-041174	Gallus gallus	71.86	0.00e+00	1535.00
IUUC-Gac-042600	Gasterosteus aculeatus	84.27	0.00e+00	1730.00
IUUC-Gma-043616	Glycine max	38.98	2.00e-53	203.00
IUUC-Ggo-044589	Gorilla gorilla	72.77	0.00e+00	1518.00
IUUC-Hsa-046772	Homo sapiens	72.89	0.00e+00	1519.00
IUUC-Kpa-049152	Komagataella pastoris	33.40	2.00e-63	237.00
IUUC-Lch-050147	Latimeria chalumnae	70.75	0.00e+00	1249.00
IUUC-Loc-052684	Lepisosteus oculatus	76.88	0.00e+00	1616.00
IUUC-Laf-053844	Loxodonta africana	72.58	0.00e+00	1497.00
IUUC-Mcc-055531	Macaca mulatta	71.38	0.00e+00	1487.00
IUUC-Mtr-058277	Medicago truncatula	36.68	3.00e-51	196.00
IUUC-Mga-060151	Meleagris gallopavo	69.92	0.00e+00	1246.00
IUUC-Mmr-060954	Microcebus murinus	73.08	0.00e+00	1504.00
IUUC-Mdo-062246	Monodelphis domestica	71.46	0.00e+00	1373.00
IUUC-Mmu-063369	Mus musculus	72.62	0.00e+00	1526.00
IUUC-Mpu-065936	Mustela putorius furo	72.05	0.00e+00	1366.00
IUUC-Mlu-067326	Myotis lucifugus	72.80	0.00e+00	1478.00
IUUC-Nle-069453	Nomascus leucogenys	73.03	0.00e+00	1503.00
IUUC-Ont-071720	Oreochromis niloticus	84.37	0.00e+00	1773.00
IUUC-Oan-073464	Ornithorhynchus anatinus	71.92	0.00e+00	1377.00
IUUC-Ocu-074207	Oryctolagus cuniculus	70.00	0.00e+00	1349.00
IUUC-Ola-086762	Oryzias latipes	81.26	0.00e+00	1673.00
IUUC-Oga-088435	Otolemur garnettii	73.36	0.00e+00	1509.00
IUUC-Oar-089233	Ovis aries	72.80	0.00e+00	1504.00
IUUC-Ptr-091368	Pan troglodytes	72.89	0.00e+00	1520.00
IUUC-Pan-092300	Papio anubis	73.08	0.00e+00	1504.00
IUUC-Psi-093406	Pelodiscus sinensis	72.51	0.00e+00	1547.00
IUUC-Pma-094113	Petromyzon marinus	65.07	0.00e+00	1035.00
IUUC-Pfo-097021	Poecilia formosa	81.02	0.00e+00	1779.00
IUUC-Pab-098327	Pongo abelii	73.08	0.00e+00	1523.00
IUUC-Pva-102909	Pteropus vampyrus	65.01	0.00e+00	1258.00
IUUC-Rno-105457	Rattus norvegicus	73.15	0.00e+00	1534.00
IUUC-Sha-106632	Sarcophilus harrisii	72.56	0.00e+00	1523.00
IUUC-Sar-113679	Sorex araneus	61.28	0.00e+00	793.00
IUUC-Tgu-116849	Taeniopygia guttata	68.39	0.00e+00	1438.00
IUUC-Tni-120233	Tetraodon nigroviridis	90.22	0.00e+00	1856.00
IUUC-Vpa-130448	Vicugna pacos	72.80	0.00e+00	1501.00
IUUC-Xtr-132719	Xenopus tropicalis	63.64	0.00e+00	1229.00
IUUC-Xma-133389	Xiphophorus maculatus	80.60	0.00e+00	1765.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence