iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050197

Ensembl Protein ID

ENSLACP00000016005.2

UniProt Accession

H3B284; H3B284_LATCH

Genbank Protein ID

ENSLACP00000016005

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01068999

Gene Name

UBE3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000014094.2	ENSLACT00000016116.2	ENSLACP00000016005.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-109	365.9	580	906

Active Site

Position(s)	Description	Evidence
875	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 580  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 663
           689******************************************998888876.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvs.eeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++llgkk ++ dl++ +p ly+slke++e+ e ++e+  + +tf++s ++++g+   ++Lk++Ge+ pVtneN++e+v+l++
   Q: 664  HFPMVVYRKLLGKKGTFRDLADSHPVLYQSLKELLEY-EGSVEDD-MMITFQISlTDLFGNPMMYDLKENGEKFPVTNENRKEFVDLYA 750
           *************************************.6677775.999999661566******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG+++id+++l+k+t+y+ggyt++s+ i+ Fwe++++f++e+++ fLq
   Q: 751  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNIDFQALEKTTEYDGGYTSESRIIREFWEIVHSFTEEQKRLFLQ 839
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYs+ke+lke+Ll Ai+++kgF++
   Q: 840  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYSNKEKLKERLLKAITYAKGFGM 906
           *****************...8888866666**************************************97 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MNSDNNEQEC ERAPPPASPT AVATSSSSAS PAPSELRSQG EPLLDNIEAS RMKRAAAKHL 60
IERYYHQLTE GCGNEACTNE FCASCPSFQR MDNNAAAIKA LELYKINSKL CDPHPSKKGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATTCCG ACAACAACGA GCAGGAGTGT GAGCGCGCGC CACCGCCCGC GAGCCCAACA 60
GCAGTAGCGA CGTCCTCGTC GTCAGCGTCA CCAGCACCGT CCGAACTCAG GTTGGTATGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

lcm:102359497

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	91.35	0.00e+00	1523.00
IUUC-Atr-003144	Amborella trichopoda	47.77	1.00e-96	347.00
IUUC-Apl-003742	Anas platyrhynchos	89.13	0.00e+00	1566.00
IUUC-Aca-004873	Anolis carolinensis	90.89	0.00e+00	1583.00
IUUC-Ago-007908	Ashbya gossypii	34.86	9.00e-70	258.00
IUUC-Ani-009176	Aspergillus nidulans	38.26	2.00e-80	294.00
IUUC-Ame-011166	Astyanax mexicanus	85.31	0.00e+00	1452.00
IUUC-Bgr-011981	Blumeria graminis	39.57	5.00e-83	303.00
IUUC-Bta-013286	Bos taurus	90.59	0.00e+00	1503.00
IUUC-Cja-019707	Callithrix jacchus	90.93	0.00e+00	1539.00
IUUC-Cfa-020154	Canis familiaris	90.59	0.00e+00	1530.00
IUUC-Cpo-021292	Cavia porcellus	90.18	0.00e+00	1506.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.06	7.00e-82	296.00
IUUC-Csa-023378	Chlorocebus sabaeus	90.59	0.00e+00	1537.00
IUUC-Cho-025059	Choloepus hoffmanni	87.38	0.00e+00	1439.00
IUUC-Cin-025643	Ciona intestinalis	44.52	0.00e+00	709.00
IUUC-Csv-026282	Ciona savignyi	44.50	0.00e+00	658.00
IUUC-Cme-027151	Cyanidioschyzon merolae	45.21	7.00e-103	369.00
IUUC-Dre-027901	Danio rerio	84.25	0.00e+00	1430.00
IUUC-Dno-029320	Dasypus novemcinctus	90.36	0.00e+00	1538.00
IUUC-Dor-030756	Dipodomys ordii	85.62	0.00e+00	678.00
IUUC-Dme-032035	Drosophila melanogaster	43.87	3.00e-165	575.00
IUUC-Eca-033843	Equus caballus	90.99	0.00e+00	1489.00
IUUC-Eeu-035109	Erinaceus europaeus	89.59	0.00e+00	1472.00
IUUC-Fca-036344	Felis catus	89.22	0.00e+00	1529.00
IUUC-Fal-036747	Ficedula albicollis	89.13	0.00e+00	1567.00
IUUC-Fox-037941	Fusarium oxysporum	39.06	5.00e-91	329.00
IUUC-Fso-038388	Fusarium solani	41.23	4.00e-89	323.00
IUUC-Gmo-038840	Gadus morhua	62.00	0.00e+00	1088.00
IUUC-Gga-040399	Gallus gallus	89.02	0.00e+00	1565.00
IUUC-Gac-041933	Gasterosteus aculeatus	85.14	0.00e+00	1407.00
IUUC-Ggo-044804	Gorilla gorilla	91.01	0.00e+00	1537.00
IUUC-Hsa-045727	Homo sapiens	91.01	0.00e+00	1537.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	87.25	0.00e+00	1423.00
IUUC-Kpa-049152	Komagataella pastoris	35.45	4.00e-63	236.00
IUUC-Loc-052743	Lepisosteus oculatus	88.67	0.00e+00	1539.00
IUUC-Lma-053245	Leptosphaeria maculans	35.20	2.00e-59	224.00
IUUC-Laf-053615	Loxodonta africana	90.48	0.00e+00	1536.00
IUUC-Mcc-054934	Macaca mulatta	90.90	0.00e+00	1534.00
IUUC-Meu-056061	Macropus eugenii	92.69	0.00e+00	1315.00
IUUC-Mor-057045	Magnaporthe oryzae	38.41	6.00e-83	303.00
IUUC-Mga-059271	Meleagris gallopavo	89.39	0.00e+00	1541.00
IUUC-Mmr-061288	Microcebus murinus	90.67	0.00e+00	1532.00
IUUC-Mdo-062975	Monodelphis domestica	92.66	0.00e+00	1580.00
IUUC-Mmu-063674	Mus musculus	89.21	0.00e+00	1489.00
IUUC-Mpu-066568	Mustela putorius furo	91.04	0.00e+00	1549.00
IUUC-Mlu-067522	Myotis lucifugus	84.15	0.00e+00	1433.00
IUUC-Nle-069505	Nomascus leucogenys	91.01	0.00e+00	1537.00
IUUC-Opr-070570	Ochotona princeps	83.51	0.00e+00	1372.00
IUUC-Ont-071527	Oreochromis niloticus	86.31	0.00e+00	1472.00
IUUC-Oan-073446	Ornithorhynchus anatinus	86.85	0.00e+00	1026.00
IUUC-Ocu-074922	Oryctolagus cuniculus	88.50	0.00e+00	1524.00
IUUC-Ola-086996	Oryzias latipes	83.49	0.00e+00	1462.00
IUUC-Oga-088261	Otolemur garnettii	90.76	0.00e+00	1510.00
IUUC-Oar-090024	Ovis aries	90.59	0.00e+00	1503.00
IUUC-Ptr-090455	Pan troglodytes	91.01	0.00e+00	1537.00
IUUC-Pan-092509	Papio anubis	89.00	0.00e+00	1370.00
IUUC-Psi-092974	Pelodiscus sinensis	89.81	0.00e+00	1541.00
IUUC-Pma-094643	Petromyzon marinus	71.95	0.00e+00	1255.00
IUUC-Pno-094886	Phaeosphaeria nodorum	36.62	9.00e-61	229.00
IUUC-Ppa-095354	Physcomitrella patens	47.06	2.00e-110	394.00
IUUC-Pfo-096905	Poecilia formosa	82.88	0.00e+00	1474.00
IUUC-Pab-097840	Pongo abelii	88.90	0.00e+00	1476.00
IUUC-Pca-100869	Procavia capensis	90.19	0.00e+00	1517.00
IUUC-Pva-103040	Pteropus vampyrus	92.26	0.00e+00	641.00
IUUC-Rno-105453	Rattus norvegicus	88.98	0.00e+00	1489.00
IUUC-Sce-106306	Saccharomyces cerevisiae	33.81	7.00e-66	245.00
IUUC-Sha-107651	Sarcophilus harrisii	92.66	0.00e+00	1580.00
IUUC-Spo-108271	Schizosaccharomyces pombe	36.98	3.00e-73	269.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	37.82	3.00e-76	280.00
IUUC-Smo-108858	Selaginella moellendorffii	50.35	3.00e-116	412.00
IUUC-Sar-113293	Sorex araneus	91.00	0.00e+00	1516.00
IUUC-Ssc-115979	Sus scrofa	91.23	0.00e+00	1520.00
IUUC-Tgu-116901	Taeniopygia guttata	89.13	0.00e+00	1566.00
IUUC-Tru-118368	Takifugu rubripes	85.47	0.00e+00	1467.00
IUUC-Tsy-119516	Tarsius syrichta	87.13	0.00e+00	1409.00
IUUC-Tni-120143	Tetraodon nigroviridis	83.53	0.00e+00	1457.00
IUUC-Tre-122108	Trichoderma reesei	40.48	1.00e-79	291.00
IUUC-Tbe-127484	Tupaia belangeri	85.22	0.00e+00	1033.00
IUUC-Ttr-129078	Tursiops truncatus	90.77	0.00e+00	1496.00
IUUC-Vda-129969	Verticillium dahliae	38.14	3.00e-84	307.00
IUUC-Vpa-130312	Vicugna pacos	83.44	0.00e+00	1282.00
IUUC-Xtr-132881	Xenopus tropicalis	90.36	0.00e+00	1548.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence