iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105874

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

RCG35087; Suppressor of cytokine-signaling 3

Genbank Nucleotide ID

AABR07030870

Gene Name

Socs3; rCG_35087

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000002946.3	ENSRNOT00000003940.3	ENSRNOP00000003940.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	96.44	9.00e-118	420.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 60
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCTGGCTCC GTGCGCCATG GTCACCCACA GCAAGTTTCC CGCCGCCGGG ATGAGCCGCC 60
CCCTGGACAC CAGCCTGCGC CTCAAGACCT TCAGCTCCAA GAGCGAGTAC CAGCTGGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0060670--P:branching involved in labyrinthine layer morphogenesis
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0050728--P:negative regulation of inflammatory response
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0060674--P:placenta blood vessel development
GO:0045597--P:positive regulation of cell differentiation
GO:0016567--P:protein ubiquitination
GO:0060708--P:spongiotrophoblast differentiation
GO:0060707--P:trophoblast giant cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	94.22	4.00e-107	380.00
IUUC-Apl-003607	Anas platyrhynchos	82.67	6.00e-97	346.00
IUUC-Aca-005063	Anolis carolinensis	82.74	8.00e-104	369.00
IUUC-Ath-006990	Arabidopsis thaliana	32.94	8.00e-03	36.20
IUUC-Ame-010859	Astyanax mexicanus	57.39	7.00e-72	263.00
IUUC-Bta-012817	Bos taurus	90.39	7.00e-110	389.00
IUUC-Bra-017963	Brassica rapa	27.14	3.10e-01	30.00
IUUC-Cja-019605	Callithrix jacchus	95.56	1.00e-111	395.00
IUUC-Cfa-021231	Canis familiaris	96.44	1.00e-108	385.00
IUUC-Cpo-022003	Cavia porcellus	89.47	5.00e-107	379.00
IUUC-Csa-023511	Chlorocebus sabaeus	96.44	5.00e-111	393.00
IUUC-Dre-028536	Danio rerio	59.57	1.00e-73	268.00
IUUC-Dno-029003	Dasypus novemcinctus	91.56	2.00e-108	384.00
IUUC-Eca-034205	Equus caballus	81.56	1.00e-67	248.00
IUUC-Fca-036317	Felis catus	93.72	2.00e-106	377.00
IUUC-Gmo-038777	Gadus morhua	63.89	8.00e-36	142.00
IUUC-Gga-041258	Gallus gallus	84.14	7.00e-97	346.00
IUUC-Gac-041837	Gasterosteus aculeatus	56.77	1.00e-65	241.00
IUUC-Ggo-045620	Gorilla gorilla	96.44	5.00e-111	393.00
IUUC-Hsa-046909	Homo sapiens	96.44	5.00e-111	393.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	89.74	9.00e-111	392.00
IUUC-Lch-049510	Latimeria chalumnae	67.25	7.00e-84	302.00
IUUC-Loc-052863	Lepisosteus oculatus	63.04	3.00e-80	290.00
IUUC-Laf-054136	Loxodonta africana	91.23	7.00e-109	386.00
IUUC-Mcc-055383	Macaca mulatta	96.44	5.00e-111	393.00
IUUC-Meu-056153	Macropus eugenii	88.05	2.00e-109	387.00
IUUC-Mmr-061185	Microcebus murinus	93.81	9.00e-107	379.00
IUUC-Mdo-061819	Monodelphis domestica	89.33	6.00e-113	399.00
IUUC-Mmu-064231	Mus musculus	98.67	9.00e-121	425.00
IUUC-Mpu-066691	Mustela putorius furo	96.44	1.00e-108	385.00
IUUC-Mlu-067673	Myotis lucifugus	94.69	5.00e-115	406.00
IUUC-Ont-072406	Oreochromis niloticus	55.02	4.00e-68	250.00
IUUC-Oan-073249	Ornithorhynchus anatinus	76.44	8.00e-94	335.00
IUUC-Ocu-074935	Oryctolagus cuniculus	84.06	2.00e-30	122.00
IUUC-Ola-087373	Oryzias latipes	48.04	3.00e-48	184.00
IUUC-Oga-088041	Otolemur garnettii	91.56	1.00e-107	382.00
IUUC-Oar-089646	Ovis aries	88.65	8.00e-103	365.00
IUUC-Ptr-091502	Pan troglodytes	96.44	5.00e-111	393.00
IUUC-Pan-091934	Papio anubis	96.44	5.00e-111	393.00
IUUC-Pfo-096412	Poecilia formosa	42.79	1.00e-48	186.00
IUUC-Pab-098554	Pongo abelii	96.44	5.00e-111	393.00
IUUC-Sha-107151	Sarcophilus harrisii	87.28	7.00e-109	385.00
IUUC-Ssc-115722	Sus scrofa	86.63	4.00e-65	239.00
IUUC-Tgu-117151	Taeniopygia guttata	84.14	1.00e-96	345.00
IUUC-Tru-118428	Takifugu rubripes	54.15	3.00e-68	251.00
IUUC-Tni-120590	Tetraodon nigroviridis	54.59	5.00e-67	246.00
IUUC-Ttr-129065	Tursiops truncatus	90.39	3.00e-109	387.00
IUUC-Xtr-132167	Xenopus tropicalis	65.78	1.00e-81	295.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence