iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-021374

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02007517

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000009175.3	ENSCPOT00000009258.2	ENSCPOP00000019221.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.60e-13	50.3	169	216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 169  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 216
           6789*************************...***************9986 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MVAHNQVAAD NAISTAAEPR RRPEPSSSPS SSPVVPARPR PCLAAPAPAP TPAPTPGDTH 60
FRTFRSHADY RRITRTSALL DACGFYWGPL SVHGAHERLR AEPVGTFLVR DSRQRNCFFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAATCT CCACGGCAGC AGAACCCCGA 60
CGGCGGCCAG AGCCTTCCTC CTCTCCCTCC TCTTCGCCCG TGGTCCCTGC ACGCCCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0019210--F:kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.25	3.00e-79	286.00
IUUC-Apl-003313	Anas platyrhynchos	71.88	1.00e-71	261.00
IUUC-Aca-005109	Anolis carolinensis	68.99	1.00e-63	235.00
IUUC-Ame-011550	Astyanax mexicanus	50.62	2.00e-49	187.00
IUUC-Bta-013411	Bos taurus	86.55	2.00e-93	334.00
IUUC-Cja-019595	Callithrix jacchus	90.32	2.00e-94	337.00
IUUC-Cfa-020563	Canis familiaris	96.89	9.00e-90	322.00
IUUC-Csa-023333	Chlorocebus sabaeus	91.24	4.00e-94	336.00
IUUC-Dre-028507	Danio rerio	47.44	6.00e-45	173.00
IUUC-Dno-029406	Dasypus novemcinctus	88.94	5.00e-93	333.00
IUUC-Ete-032399	Echinops telfairi	88.94	3.00e-92	330.00
IUUC-Eca-033519	Equus caballus	81.57	8.00e-89	319.00
IUUC-Fal-036726	Ficedula albicollis	58.72	2.00e-73	268.00
IUUC-Gmo-039667	Gadus morhua	50.44	9.00e-27	112.00
IUUC-Gga-040970	Gallus gallus	60.37	1.00e-71	262.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.62	4.00e-36	144.00
IUUC-Ggo-045569	Gorilla gorilla	86.64	5.00e-95	339.00
IUUC-Hsa-046010	Homo sapiens	90.78	2.00e-93	334.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	99.38	2.00e-92	331.00
IUUC-Lch-050219	Latimeria chalumnae	63.29	6.00e-63	233.00
IUUC-Loc-052494	Lepisosteus oculatus	58.49	3.00e-55	207.00
IUUC-Laf-054219	Loxodonta africana	96.32	6.00e-72	262.00
IUUC-Mcc-054830	Macaca mulatta	93.09	5.00e-94	336.00
IUUC-Meu-056565	Macropus eugenii	70.51	8.00e-81	292.00
IUUC-Mga-060153	Meleagris gallopavo	59.45	8.00e-71	259.00
IUUC-Mmr-061365	Microcebus murinus	90.41	1.00e-92	332.00
IUUC-Mdo-062824	Monodelphis domestica	68.66	1.00e-79	288.00
IUUC-Mmu-064120	Mus musculus	87.56	6.00e-92	329.00
IUUC-Mpu-066839	Mustela putorius furo	89.86	1.00e-94	338.00
IUUC-Mlu-067829	Myotis lucifugus	87.10	2.00e-91	327.00
IUUC-Nle-069592	Nomascus leucogenys	86.18	2.00e-89	321.00
IUUC-Ont-072173	Oreochromis niloticus	45.62	3.00e-38	151.00
IUUC-Oan-073586	Ornithorhynchus anatinus	54.21	3.00e-26	110.00
IUUC-Ocu-073996	Oryctolagus cuniculus	99.38	5.00e-92	329.00
IUUC-Oba-075150	Oryza barthii	30.59	3.70e-02	31.20
IUUC-Ola-087158	Oryzias latipes	46.88	7.00e-40	156.00
IUUC-Oga-088076	Otolemur garnettii	88.99	2.00e-93	334.00
IUUC-Ptr-091241	Pan troglodytes	90.32	1.00e-94	338.00
IUUC-Pan-091836	Papio anubis	87.10	1.00e-94	338.00
IUUC-Psi-093628	Pelodiscus sinensis	61.75	2.00e-73	268.00
IUUC-Pfo-097501	Poecilia formosa	45.91	3.00e-37	148.00
IUUC-Pab-098170	Pongo abelii	91.24	2.00e-93	334.00
IUUC-Pop-100072	Populus trichocarpa	32.69	1.10e-02	33.90
IUUC-Pva-102796	Pteropus vampyrus	92.17	4.00e-93	333.00
IUUC-Rno-105319	Rattus norvegicus	87.56	6.00e-92	329.00
IUUC-Sha-107201	Sarcophilus harrisii	80.52	1.00e-73	268.00
IUUC-Ssc-116004	Sus scrofa	86.82	1.00e-95	341.00
IUUC-Tgu-116836	Taeniopygia guttata	60.83	1.00e-72	265.00
IUUC-Tru-118090	Takifugu rubripes	43.75	1.00e-36	145.00
IUUC-Tni-120719	Tetraodon nigroviridis	44.38	2.00e-32	132.00
IUUC-Vpa-130235	Vicugna pacos	91.71	2.00e-93	334.00
IUUC-Xtr-132610	Xenopus tropicalis	55.76	2.00e-67	248.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence