iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091241

UUCD1 version

UUC-PaT-00298

Ensembl Protein ID

ENSPTRP00000013256.2

UniProt Accession

H2QAK6; H2QAK6_PANTR

Genbank Protein ID

JAA02848.1; JAA22258.1; JAA41176.1

Protein Name

Suppressor of cytokine signaling 1

Genbank Nucleotide ID

AACZ03105748; GABD01010842; GABE01003563

Gene Name

SOCS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000007765.2	ENSPTRT00000014304.2	ENSPTRP00000013256.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-13	50.4	163	210

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            ++l+++++r+Lq+LCR +I+ ++g+++l    ++PL+++L+dYL+++++q
   Q: 163  GAPLRQRRVRPLQELCRQRIVATVGRENL---ARIPLNPVLRDYLSSFPFQ 210
           6789*************************...***************9986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSSAAPARPR PCPAVPAPAP GDTHFRTFRS 60
HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT FLVRDSRQRN CFFALSVKMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTAGCAC ACAACCAGGT GGCAGCCGAC AATGCAGTCT CCACAGCAGC AGAGCCCCGA 60
CGGCGGCCAG AACCTTCCTC CTCTTCCTCC TCCTCGTCCG CGGCCCCCGC GCGCCCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028411--SOCS1
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0000932--C:P-body
GO:0004860--F:protein kinase inhibitor activity
GO:0071230--P:cellular response to amino acid stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0007259--P:JAK-STAT cascade
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0042512--P:negative regulation of tyrosine phosphorylation of Stat1 protein
GO:0042518--P:negative regulation of tyrosine phosphorylation of Stat3 protein
GO:0016567--P:protein ubiquitination
GO:0010534--P:regulation of activation of JAK2 kinase activity
GO:0050707--P:regulation of cytokine secretion
GO:0060334--P:regulation of interferon-gamma-mediated signaling pathway

KEGG

ptr:737070

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001204	Ailuropoda melanoleuca	91.88	6.00e-80	289.00
IUUC-Apl-003313	Anas platyrhynchos	60.66	9.00e-73	265.00
IUUC-Aca-005109	Anolis carolinensis	68.35	3.00e-63	234.00
IUUC-Ame-011550	Astyanax mexicanus	50.00	6.00e-49	186.00
IUUC-Bta-013411	Bos taurus	86.10	4.00e-94	337.00
IUUC-Cja-019595	Callithrix jacchus	98.58	2.00e-97	347.00
IUUC-Cfa-020563	Canis familiaris	97.52	2.00e-90	324.00
IUUC-Cpo-021374	Cavia porcellus	93.55	2.00e-95	341.00
IUUC-Csa-023333	Chlorocebus sabaeus	97.65	2.00e-95	341.00
IUUC-Dre-028507	Danio rerio	46.79	1.00e-44	172.00
IUUC-Dno-029406	Dasypus novemcinctus	91.47	2.00e-94	337.00
IUUC-Ete-032399	Echinops telfairi	94.79	2.00e-93	334.00
IUUC-Eca-033519	Equus caballus	83.89	2.00e-91	327.00
IUUC-Fal-036726	Ficedula albicollis	60.66	4.00e-74	270.00
IUUC-Gmo-039667	Gadus morhua	50.44	8.00e-27	113.00
IUUC-Gga-040970	Gallus gallus	61.14	1.00e-72	265.00
IUUC-Gac-041838	Gasterosteus aculeatus	45.00	1.00e-35	142.00
IUUC-Ggo-045569	Gorilla gorilla	90.52	1.00e-96	344.00
IUUC-Hsa-046010	Homo sapiens	99.53	4.00e-96	343.00
IUUC-Itr-047995	Ictidomys tridecemlineatus	93.36	6.00e-93	332.00
IUUC-Lch-050219	Latimeria chalumnae	62.66	1.00e-62	231.00
IUUC-Loc-052494	Lepisosteus oculatus	57.86	7.00e-55	206.00
IUUC-Laf-054219	Loxodonta africana	96.32	2.00e-72	264.00
IUUC-Mcc-054830	Macaca mulatta	97.21	3.00e-95	340.00
IUUC-Meu-056565	Macropus eugenii	70.14	2.00e-81	294.00
IUUC-Mga-060153	Meleagris gallopavo	61.14	5.00e-72	263.00
IUUC-Mmr-061365	Microcebus murinus	90.41	2.00e-93	334.00
IUUC-Mdo-062824	Monodelphis domestica	70.09	6.00e-79	286.00
IUUC-Mmu-064120	Mus musculus	88.21	4.00e-92	330.00
IUUC-Mpu-066839	Mustela putorius furo	91.20	2.00e-95	340.00
IUUC-Mlu-067829	Myotis lucifugus	88.15	8.00e-92	329.00
IUUC-Nle-069592	Nomascus leucogenys	89.10	6.00e-91	326.00
IUUC-Ont-072173	Oreochromis niloticus	45.00	6.00e-38	150.00
IUUC-Oan-073586	Ornithorhynchus anatinus	54.21	3.00e-26	110.00
IUUC-Ocu-073996	Oryctolagus cuniculus	98.76	5.00e-92	329.00
IUUC-Oba-075150	Oryza barthii	30.59	3.00e-02	31.20
IUUC-Ola-087158	Oryzias latipes	46.25	2.00e-39	155.00
IUUC-Oga-088076	Otolemur garnettii	91.51	2.00e-93	334.00
IUUC-Pan-091836	Papio anubis	90.52	4.00e-96	343.00
IUUC-Psi-093628	Pelodiscus sinensis	63.98	2.00e-74	271.00
IUUC-Pfo-097501	Poecilia formosa	45.28	6.00e-37	147.00
IUUC-Pab-098170	Pongo abelii	97.65	1.00e-94	338.00
IUUC-Pop-100072	Populus trichocarpa	32.69	8.00e-03	34.30
IUUC-Pva-102796	Pteropus vampyrus	97.18	5.00e-94	336.00
IUUC-Rno-105319	Rattus norvegicus	88.68	4.00e-92	330.00
IUUC-Sha-107201	Sarcophilus harrisii	81.17	2.00e-74	270.00
IUUC-Ssc-116004	Sus scrofa	90.45	9.00e-96	342.00
IUUC-Tgu-116836	Taeniopygia guttata	73.29	3.00e-73	267.00
IUUC-Tru-118090	Takifugu rubripes	43.12	3.00e-36	144.00
IUUC-Tni-120719	Tetraodon nigroviridis	43.75	4.00e-32	130.00
IUUC-Vpa-130235	Vicugna pacos	92.56	3.00e-94	337.00
IUUC-Xtr-132610	Xenopus tropicalis	57.82	4.00e-67	247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence